Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
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Alexies Dagnino-Subiabre
Dr. Alexies Dagnino-Subiabre earned a BA in Biochemistry from Universidad Austral de Chile, Valdivia (1999), and a PhD in Biomedical Sciences from the Universidad de Chile in Santiago (2003). After completing postdoctoral fellowships at the Pontificia Universidad Católica de Chile, Santiago, and research stays at the University of Texas (Atzori Lab) and Stanford University (Sapolsky Lab), USA, Dr. Dagnino-Subiabre joined the faculty as an Associate Professor in the Department of Biomedical Sciences at the Universidad Católica del Norte (2006). Currently, Dr. Dagnino- Subiabre is Associate Professor of Neurosciences at the Universidad de Valparaíso, Chile, where he pursues research aimed to understand the effects of chronic stress on emotional processing of sounds, learning and memory.
Abstract
Stress is a complex biological reaction common to all living organisms that allows them to adapt to their environments. Chronic stress alters the dendritic architecture and function of the limbic brain areas that affect memory, learning, and emotional processing. This review summarizes our research about chronic stress effects on the auditory system, providing the details of how we developed the main hypotheses that currently guide our research. The aims of our studies are to (1) determine how chronic stress impairs the dendritic morphology of the main nuclei of the rat auditory system, the inferior colliculus (auditory mesencephalon), the medial geniculate nucleus (auditory thalamus), and the primary auditory cortex; (2) correlate the anatomic alterations with the impairments of auditory fear learning; and (3) investigate how the stress-induced alterations in the rat limbic system may spread to nonlimbic areas, affecting specific sensory system, such as the auditory and olfactory systems, and complex cognitive functions, such as auditory attention. Finally, this article gives a new evolutionary approach to understanding the neurobiology of stress and the stress-related disorders.
About the author
Dr. Alexies Dagnino-Subiabre earned a BA in Biochemistry from Universidad Austral de Chile, Valdivia (1999), and a PhD in Biomedical Sciences from the Universidad de Chile in Santiago (2003). After completing postdoctoral fellowships at the Pontificia Universidad Católica de Chile, Santiago, and research stays at the University of Texas (Atzori Lab) and Stanford University (Sapolsky Lab), USA, Dr. Dagnino-Subiabre joined the faculty as an Associate Professor in the Department of Biomedical Sciences at the Universidad Católica del Norte (2006). Currently, Dr. Dagnino- Subiabre is Associate Professor of Neurosciences at the Universidad de Valparaíso, Chile, where he pursues research aimed to understand the effects of chronic stress on emotional processing of sounds, learning and memory.
©2013 by Walter de Gruyter Berlin Boston
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- Masthead
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- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- The role of the subthalamic nucleus in cognition
- Physical exercise and Parkinson’s disease: influence on symptoms, disease course and prevention
- The role of serotonin in the antidyskinetic effects of deep brain stimulation: focus on antipsychotic-induced motor symptoms
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- Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
- Effects of chronic stress on the auditory system and fear learning: an evolutionary approach
