Startseite Putting an object in context and acting on it: neural mechanisms of goal-directed response to contextual object
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Putting an object in context and acting on it: neural mechanisms of goal-directed response to contextual object

  • Inah Lee

    Dr. Inah Lee received his PhD in Neuroscience under the supervision of Dr. Raymond Kesner from the University of Utah in 2002. Dr. Lee published several seminal papers investigating the functional significance of different subfields of the hippocampus in learning and memory using behavioral paradigms combined with lesion and inactivation techniques during his doctoral training period. He spent 2 years in Dr. James Knierim’s lab at the University of Texas Medical School at Houston as a postdoctoral researcher, during which time he published a seminal article in Nature showing the neural firing correlates of hippocampal computational processes based on an electrophysiological experiment using freely moving animals. He worked as a postdoctoral researcher for another 1.5 years in the Center for Memory and Brain with Dr. Howard Eichenbaum and Dr. Michael Hasselmo, further investigating how neural firing patterns dynamically changed when rats performed a goal-directed memory task. Dr. Lee spent 3 years in the Department of Psychology at the University of Iowa as an assistant professor and is currently an associate professor of the Department of Brain and Cognitive Sciences at the Seoul National University. His research interest is in understanding the neural mechanisms of context memory-dependent choice behavior involving the hippocampus and its associated areas, such as the prefrontal cortex, striatum and cortical regions in the medial temporal lobe.

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    und Sang-Hun Lee

    Dr. Sang-Hun Lee is currently an associate professor in the Department of Brain and Cognitive Sciences at the Seoul National University. Dr. Lee received his PhD in Visual Neuroscience from Vanderbilt University in 2001. From 2001–2004, he spent three years at Stanford University and New York University as a post-doctoral fellow in David Heeger’s computational neuroimaging laboratory at the Center for Neuroscience. Dr. Lee’s early studies focused on the behavioral aspects of human visual perception; he published several influential papers on binocular vision, temporal vision and visual grouping using methods of pychophysics. He later gained expertise in brain imaging and functional magnetic resonance imaging (fMRI). He has tried to establish links between perceptual dynamics in human vision and neural dynamics in the cerebral cortex by combining diverse data collected from psychophysical, brain imaging and computational modeling experiments. He received the William James Young Investigator Award from the Association for the Scientific Study of Consciousness in 2006 and was chosen as one of the Frontier Scientists by the Korean Ministry of Science and Technology (2009) in recognition of his recent pioneering work on visual awareness and brain activity. He has also recently launched a new department, the Department of Brain and Cognitive Sciences (http://bcs.snu.ac.kr), at the Seoul National University by leading a team of international scholars. He is an acting chair of this new department and also directs the SNU Brain Imaging Center, which houses a 3-T research-devoted MRI scanner.

Veröffentlicht/Copyright: 23. November 2012
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Abstract

Animals including humans experience objects in a certain environment, that is, a context. Same objects may have to be treated differently, or different objects may need to be treated similarly depending on contexts. Flexible behavioral choice in such ambiguous situations involves dynamic interactions among brain regions, but underlying neural mechanisms are poorly understood. In this article, prior studies that have examined (mostly in rodents) some of the brain regions involved in contextual processing of object information using goal-directed tasks are selectively reviewed. The current review identifies the hippocampus, prefrontal cortex (PFC) and perirhinal cortex (PER) as key regions for associating the same objects with different reward values and responses depending on the background visual context. The hippocampus is particularly important for contextual choice behavior when the context must be used as a conditional cue that can disambiguate reward-related ‘meanings’ of objects. The PER appears to play significant roles in such tasks during initial learning (but not so much for retrieval) because perturbations in the PER produce severe deficits in the acquisition of the contextual object memory task. Perturbations in the PFC also affect performance when flexible contextual responses should be made toward otherwise ambiguous objects.


Corresponding author: Inah Lee, Department of Brain and Cognitive Sciences, Seoul National University, Gwanak, 151–742 Seoul, Korea

About the authors

Inah Lee

Dr. Inah Lee received his PhD in Neuroscience under the supervision of Dr. Raymond Kesner from the University of Utah in 2002. Dr. Lee published several seminal papers investigating the functional significance of different subfields of the hippocampus in learning and memory using behavioral paradigms combined with lesion and inactivation techniques during his doctoral training period. He spent 2 years in Dr. James Knierim’s lab at the University of Texas Medical School at Houston as a postdoctoral researcher, during which time he published a seminal article in Nature showing the neural firing correlates of hippocampal computational processes based on an electrophysiological experiment using freely moving animals. He worked as a postdoctoral researcher for another 1.5 years in the Center for Memory and Brain with Dr. Howard Eichenbaum and Dr. Michael Hasselmo, further investigating how neural firing patterns dynamically changed when rats performed a goal-directed memory task. Dr. Lee spent 3 years in the Department of Psychology at the University of Iowa as an assistant professor and is currently an associate professor of the Department of Brain and Cognitive Sciences at the Seoul National University. His research interest is in understanding the neural mechanisms of context memory-dependent choice behavior involving the hippocampus and its associated areas, such as the prefrontal cortex, striatum and cortical regions in the medial temporal lobe.

Sang-Hun Lee

Dr. Sang-Hun Lee is currently an associate professor in the Department of Brain and Cognitive Sciences at the Seoul National University. Dr. Lee received his PhD in Visual Neuroscience from Vanderbilt University in 2001. From 2001–2004, he spent three years at Stanford University and New York University as a post-doctoral fellow in David Heeger’s computational neuroimaging laboratory at the Center for Neuroscience. Dr. Lee’s early studies focused on the behavioral aspects of human visual perception; he published several influential papers on binocular vision, temporal vision and visual grouping using methods of pychophysics. He later gained expertise in brain imaging and functional magnetic resonance imaging (fMRI). He has tried to establish links between perceptual dynamics in human vision and neural dynamics in the cerebral cortex by combining diverse data collected from psychophysical, brain imaging and computational modeling experiments. He received the William James Young Investigator Award from the Association for the Scientific Study of Consciousness in 2006 and was chosen as one of the Frontier Scientists by the Korean Ministry of Science and Technology (2009) in recognition of his recent pioneering work on visual awareness and brain activity. He has also recently launched a new department, the Department of Brain and Cognitive Sciences (http://bcs.snu.ac.kr), at the Seoul National University by leading a team of international scholars. He is an acting chair of this new department and also directs the SNU Brain Imaging Center, which houses a 3-T research-devoted MRI scanner.

Received: 2012-6-5
Accepted: 2012-9-5
Published Online: 2012-11-23
Published in Print: 2013-02-01

©2013 by Walter de Gruyter Berlin Boston

Heruntergeladen am 19.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/revneuro-2012-0073/html
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