Soluble guanylate cyclase in NO signaling transduction
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Xiangshi Tan is a Professor of Chemistry and Biomedical Science of Fudan University, Shanghai, China. He received his PhD degree from Nanjing University in 1996, and after that he did postdoctoral research in CEA/Grenoble, France; Edinburgh University, UK; Ibaraki University, Japan. In 2000, Dr. Tan moved to Texas A & M University, USA and worked there for almost 8 years as a research scientist of Bioinorganic Chemistry. In 2007, he took the full Professor position of Fudan University, and he is also a visiting Professor of Texas A & M University. Dr. Tan’s research activities focus on Bioinorganic Chemistry & Chemical Biology of metalloenzymes and metalloproteins in physiology and pathology.
Jie Pan is a PhD student in the Department of Chemistry of Fudan University, China. Her research is focused on structure, functions and mechanism of soluble guanylate cyclase (sGC). She has been working with Prof. Tan for more than 3 years on the project of sGC.
Fangfang Zhong received her PhD degree in Bioinorganic Chemistry from Fudan University in 2012 under the supervision of Prof. Tan, where her research activity was mainly focused on the expression, characterization and molecular mechanism of NO-signaling mediated by human soluble guanylate cyclase. She is currently a postdoctoral research associate at Dartmouth College, USA.
Abstract
Nitric oxide (NO), a signaling molecule in the cardiovascular system, has been receiving increasing attention since Furchgott, Ignarro, and Murad were awarded the Nobel Prize in Physiology and Medicine for the discovery in 1998. Soluble guanylate cyclase (sGC), as an NO receptor, is a key metalloprotein in mediating NO signaling transduction. sGC is activated by NO to catalyze the conversion of guanosine 5′-triphosphate (GTP) to cyclic guanylate monophosphate (cGMP). The dysfunction of NO signaling results in many pathological disorders, including several cardiovascular diseases, such as arterial hypertension, pulmonary hypertension, heart failure and so on. Significant advances in its structure, function, mechanism, and physiological and pathological roles have been made throughout the past 15 years. We herein review the progress of sGC on structural, functional investigations, as well as the proposed activation/deactivation mechanism. The heme-dependent sGC stimulators and heme-independent sGC activators have also been summarized briefly.
About the authors
Xiangshi Tan is a Professor of Chemistry and Biomedical Science of Fudan University, Shanghai, China. He received his PhD degree from Nanjing University in 1996, and after that he did postdoctoral research in CEA/Grenoble, France; Edinburgh University, UK; Ibaraki University, Japan. In 2000, Dr. Tan moved to Texas A & M University, USA and worked there for almost 8 years as a research scientist of Bioinorganic Chemistry. In 2007, he took the full Professor position of Fudan University, and he is also a visiting Professor of Texas A & M University. Dr. Tan’s research activities focus on Bioinorganic Chemistry & Chemical Biology of metalloenzymes and metalloproteins in physiology and pathology.
Jie Pan is a PhD student in the Department of Chemistry of Fudan University, China. Her research is focused on structure, functions and mechanism of soluble guanylate cyclase (sGC). She has been working with Prof. Tan for more than 3 years on the project of sGC.
Fangfang Zhong received her PhD degree in Bioinorganic Chemistry from Fudan University in 2012 under the supervision of Prof. Tan, where her research activity was mainly focused on the expression, characterization and molecular mechanism of NO-signaling mediated by human soluble guanylate cyclase. She is currently a postdoctoral research associate at Dartmouth College, USA.
This work was supported partly by the National Natural Science Foundation of China (No. 91013001, No. 20771029, No. 31270869), the Ph.D. Program of the Education Ministry of China (20100071110011), the high magnetic field laboratory of Chinese Academy of Science, and the Shanghai Synchrotron Radiation Facility (SSRF).
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