Startseite Exposure to cadmium and head and neck cancers: a meta-analysis of observational studies
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Exposure to cadmium and head and neck cancers: a meta-analysis of observational studies

  • Maysam Rezapour ORCID logo , Habib Allah Rezapour , Maryam Chegeni und Narges Khanjani ORCID logo EMAIL logo
Veröffentlicht/Copyright: 1. Februar 2021
Reviews on Environmental Health
Aus der Zeitschrift Reviews on Environmental Health Band 36 Heft 4

Abstract

Cadmium (Cd) is a widespread environmental pollutant. A number of observational studies have reported that Cd might be a cause of nasopharyngeal (NPC), pharyngeal (PC), or laryngeal cancers (LC). In this study evidence about the relation of Cd and NPC, PC, and LC has been summarized. A literature review was conducted until 20 June 2020 in PubMed, Ovid, Scopus, Web of Science and Google scholar databases to investigate the epidemiologic evidence for the relation between cadmium exposure and cancers of the nasopharynx, pharynx, and larynx. Ten articles were selected after careful screening of retrieved studies. All of these studies obtained a Newcastle-Ottawa Scale (NOS) quality score from 6 to 8. Due to high heterogeneity, in all analyses, random effect was used. The pooled results showed that cadmium levels in NPC (standard mean difference (SMD=0.55; 95% CI=0.20, 0.89; p=0.002) and PC (SMD=9.79; 95% CI=0.62, 18.96; p=0.036) patients/tissues were significantly higher than their controls. But cadmium levels were not significantly different between LC cases/tissues and their controls. (SMD=−0.05; 95% CI=−0.99, 0.89; p=0.921). Exposure to cadmium is likely to cause nasopharyngeal and pharyngeal cancer.

Keywords: cadmium; cancer; laryngeal; nasopharyngeal; pharyngeal
Corresponding author: Prof. Narges Khanjani, Environmental Health Engineering Research Center and Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran, Phone/Fax: +98 34 3132 5102, E-mail:

  1. Research funding: Authors state no funding involved.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent is not applicable.

  5. Ethical approval: Ethic approval was not needed.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/reveh-2020-0109).

Received: 2020-08-25
Accepted: 2021-01-10
Published Online: 2021-02-01
Published in Print: 2021-12-20

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/reveh-2020-0109
Schlagwörter für diesen Artikel
cadmium; cancer; laryngeal; nasopharyngeal; pharyngeal

Artikel in diesem Heft

  1. Frontmatter
  2. Short Communication
  3. Greater than the sum of its parts: focusing SRP research through a systems approach lens
  4. Review Articles
  5. Association of bisphenol A with puberty timing: a meta-analysis
  6. Pesticide applicators and cancer: a systematic review
  7. Current knowledge on urease and nitrification inhibitors technology and their safety
  8. Environment as the risk factor for tuberculosis in Malaysia: a systematic review of the literature
  9. Effects of ambient air pollution on psychological stress and anxiety disorder: a systematic review and meta-analysis of epidemiological evidence
  10. The possible role of arsenic and gene-arsenic interactions in susceptibility to breast cancer: a systematic review
  11. Ambient air pollution and multiple sclerosis: a systematic review
  12. Mitochondria and traffic-related air pollution linked coronary artery calcification: exploring the missing link
  13. Air pollutants and impairments of male reproductive health-an overview
  14. Exposure to cadmium and head and neck cancers: a meta-analysis of observational studies
  15. Lost opportunities for cancer prevention: historical evidence on early warnings with emphasis on radiofrequency radiation
  16. Health protection messaging for populations susceptible to air pollution during landscape fire smoke events: an integrative review
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