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Preparation, characterization, and bioevaluation of 99mTc-famotidine as a selective radiotracer for peptic ulcer disorder detection in mice

  • M. H. Sanad EMAIL logo , Ayman B. Farag EMAIL logo , F. A. Marzook and Sudip Kumar Mandal
Published/Copyright: November 2, 2021
Radiochimica Acta
From the journal Radiochimica Acta Volume 110 Issue 1

Abstract

This work focuses on tracking peptic ulcer localized in mice. The formation of a [99mTc]dithiocarbamate of famotidine complex at optimum conditions of reaction temperature (37 °C), reaction time (30 min), pH of the reaction mixture (5), amount of substrate (100 µg), amount of reducing agent (tin (II) content, 50 µg), was achieved using radioactive Tc-99m (250–400 MBq), with labelling yield of 98% and high radiochemical purity. The in-vitro stability of [99mTc]dithiocarbamate of famotidine complex was shown to be high in rat serum for up to 8 h. Normal and ulcerated mice were used in biodistribution studies. Famotidine works by blocking histamine-2-receptor antagonists (H2RAs). The high absorption of [99mTc]dithiocarbamate of famotidine complex in stomach in amount of 27.15% injected dose/g organ (ID/g) observed in ulcerated mice for up to 24 h demonstrated its usefulness as a novel radiotracer for stomach imaging.

Keywords: complex; biodistribution; famotidine; histamine-2-receptor; stomach ulcers imaging
M. H. Sanad, Labeled Compounds Department, Hot Laboratories Center, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt; and Department of Physics and Engineering Mathematics, Faculty of Engineering, Ain Shams University, P.O. Box 11566, Cairo, Egypt, E-mail: ; and Corresponding author: Ayman B. Farag, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2021-09-16
Accepted: 2021-10-13
Published Online: 2021-11-02
Published in Print: 2022-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Activation cross sections of some neutron-induced reactions in the energy range of 13.82–14.71 MeV
  4. New reference materials for trace-levels of actinide elements in plutonium
  5. Adsorption properties and mechanism of uranium by three biomass materials
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  7. Review
  8. Application of response surface method in the separation of radioactive material: a review
  9. Original Paper
  10. Preparation, characterization, and bioevaluation of 99mTc-famotidine as a selective radiotracer for peptic ulcer disorder detection in mice
https://doi.org/10.1515/ract-2021-1105
Keywords for this article
complex; biodistribution; famotidine; histamine-2-receptor; stomach ulcers imaging

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Activation cross sections of some neutron-induced reactions in the energy range of 13.82–14.71 MeV
  4. New reference materials for trace-levels of actinide elements in plutonium
  5. Adsorption properties and mechanism of uranium by three biomass materials
  6. Synthesis of “(aminomethyl)phosphonic acid-functionalized graphene oxide”, and comparison of its adsorption properties for thorium(IV) ion, with plain graphene oxide
  7. Review
  8. Application of response surface method in the separation of radioactive material: a review
  9. Original Paper
  10. Preparation, characterization, and bioevaluation of 99mTc-famotidine as a selective radiotracer for peptic ulcer disorder detection in mice
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