Synthesis, characterization, and bioevaluation of 99mTc nitrido-oxiracetam as a brain imaging model
-
M. H. Sanad
and
A. B. Farag
Abstract
In this work, the radiotracer [99mTc]nitrido-oxiracetam complex was labeled in the presence of 99mTc-nitrido as a core. In order to get the highest radiochemical purity, many effective factors have been studied such as temperature of the reaction, time of the reaction, the pH of the reaction mixture, substrate amount, and stability to give high percent more than 99%. Finally, biodistribution studies have been indicated the convenience of [99mTc]nitrido-oxiracetam as a new radiotracer that could be used in brain imaging. Giving a maximum uptake of 10.6% at 30 min post injection.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: All Authors declare that they have no conflict of interest.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Original Papers
- Extraction behavior of Pu(IV), Th(IV), and fission product elements with hexapropyl and hexabutyl phosphoramides
- Impact of selected cement additives and model compounds on the solubility of Nd(III), Th(IV) and U(VI): screening experiments in alkaline NaCl, MgCl2 and CaCl2 solutions at elevated ionic strength
- Liquid-liquid extraction of Nd+3 and Eu+3 from aqueous medium using oxytetracycline in dichloromethane
- Preparation of a carrier free 124Sb tracer produced in the Sn (p, n) reaction
- Utilization of nanotechnology in targeted radionuclide cancer therapy: monotherapy, combined therapy and radiosensitization
- Synthesis, characterization, and bioevaluation of 99mTc nitrido-oxiracetam as a brain imaging model
- Physico-mechanical comparative study on gamma irradiated high density polyethylene/eggshell and commercial calcium carbonate composites
- Determination of scalp hair selenium concentrations in Algerian psoriatic individuals using k0-standardization based on neutron activation analysis method
- Alpha track registration and revelation in CR-39 using new etching method for ultratrace alpha radioactivity quantification in solution media
