CdTe quantum dots on gold-198 nano particles: introducing a novel theranostic agent
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Ariam Rasekholghol
,
Shahram Moradi Dehaghi
Abstract
The influence of coating a CdTe quantum dots (QDs) layer on the 198Au nanoparticles (NPs) in biodistribution of 198Au nanoparticles was investigated. The 198Au nanoparticles were prepared by irradiating the highly pure metallic gold in Tehran research nuclear reactor and subsequently 198Au-NPs were synthesized and subjected to surface modification with cysteamine and CdTe QDs to form an adduct. The prepared nanomaterials were characterized with X-ray diffraction, radio thin layer chromatography, transmission electron microscopy, and scanning electron microscopy. In-vivo biodistribution and tumor avidity studies were performed by intravenously injecting of cysteamine@198AuNPs: CdTe QDs nanocomposite into rats. The %ID/g (percent of the initial dose per gram tissue weight) in dissected organs and Fibrosarcoma tumor specimens was then measured. The hydrophilicity of the cysteamine@198AuNPs was increased by surface modification with CdTe QDs. Rapid excretion from body and high tumor uptake for cysteamine@198AuNPs: CdTe QDs revealed that this radiotracer could potentially be used in nuclear medicine as a theranostic agent.
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Papers
- Validation of nuclear reaction models for incident α-particles
- Efficient removal of radiocobalt and manganese from their binary aqueous solutions by batch adsorption process using PAN/HDTMA/KCuHCF composite
- Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging
- Effect of gamma irradiation and oxidized bitumen on the performance of the modified crumb rubber for various applications
- CdTe quantum dots on gold-198 nano particles: introducing a novel theranostic agent
- Dosimetry and methodology of gamma irradiation for degradation studies on solvent extraction systems
Articles in the same Issue
- Frontmatter
- Original Papers
- Validation of nuclear reaction models for incident α-particles
- Efficient removal of radiocobalt and manganese from their binary aqueous solutions by batch adsorption process using PAN/HDTMA/KCuHCF composite
- Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging
- Effect of gamma irradiation and oxidized bitumen on the performance of the modified crumb rubber for various applications
- CdTe quantum dots on gold-198 nano particles: introducing a novel theranostic agent
- Dosimetry and methodology of gamma irradiation for degradation studies on solvent extraction systems
