Development of a novel 68Ga-dextran carboxylate derivative for blood pool imaging
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Nazila Gholipour
Abstract
To develop a possible PET blood pool imaging agent, a series 68Ga-dextran carboxylate derivatives were prepared. Dextran carboxylates with different degree of oxidations (DO) were prepared through stepwise dextran oxidation using NaIO4 and CH3COOOH. The products were characterized by FT-IR and GPC, followed by solubility and toxicity tests on Hella cells (viability=98.6, 97.4 and 95.6% for 3 dextran carboxylates with DOs: 8.3, 24.6 and 39.8%, respectively. The products were labeled with 68Ga (radiochemical purity>98%; ITLC) followed by stability tests in final solution as well as in presence of cycteine and human serum. Two stable tracers (DOs; 24.6 and 39.8%) were adminstered intravenously into wild type rat tail vein separately demonstrating suitable retention in circulation as expected from blood pool imaging agents. Liver and spleen also contained activities. The major excretion was through urinary pathway esp. for derivative with DO. 39.8%. Unlike 68Ga-dextran, lungs showed lower uptake. The dextran carboxylate with the highest 39.8% showed the best characteristics for a blood pool agent, though more studies including PET imaging in larger mammals are required.
Funding source: Tehran University of Medical Sciences
Award Identifier / Grant number: 94-02-58-29793
Funding statement: This research has been supported by Tehran University of Medical Sciences (TUMS), Funder Id: http://dx.doi.org/10.13039/501100004484, grant 94-02-58-29793.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Uranium oxide synthetic pathway discernment through thermal decomposition and morphological analysis
- Applications of the uranium’s set of isotopes for nuclear dating: the Monte-Carlo method
- Quantification of trace level rare earth elements in Al matrices by ICP-MS
- Synergistic effect of vermiculite clay and ionizing irradiation on the physical and mechanical properties of polybutadiene rubber/ethylene propylene diene monomer nanocomposite
- Development of a novel 68Ga-dextran carboxylate derivative for blood pool imaging
- Distribution of naturally occurring radionuclides in soil around a coal-based power plant and their potential radiological risk assessment
- Investigation of γ ray shielding, structural and dissolution rate studies of alkali based bismuth borate glass systems with MoO3 added
- Novel radiochromic porphyrin-based film dosimeters for γ ray dosimetry: investigation on metal and ligand effects
Articles in the same Issue
- Frontmatter
- Uranium oxide synthetic pathway discernment through thermal decomposition and morphological analysis
- Applications of the uranium’s set of isotopes for nuclear dating: the Monte-Carlo method
- Quantification of trace level rare earth elements in Al matrices by ICP-MS
- Synergistic effect of vermiculite clay and ionizing irradiation on the physical and mechanical properties of polybutadiene rubber/ethylene propylene diene monomer nanocomposite
- Development of a novel 68Ga-dextran carboxylate derivative for blood pool imaging
- Distribution of naturally occurring radionuclides in soil around a coal-based power plant and their potential radiological risk assessment
- Investigation of γ ray shielding, structural and dissolution rate studies of alkali based bismuth borate glass systems with MoO3 added
- Novel radiochromic porphyrin-based film dosimeters for γ ray dosimetry: investigation on metal and ligand effects
