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Cross-section measurements and production of 72Se with medium to high energy protons using arsenic containing targets

  • Anthony J. DeGraffenreid , Dmitri G. Medvedev , Timothy E. Phelps , Matthew D. Gott , Suzanne V. Smith , Silvia S. Jurisson and Cathy S. Cutler EMAIL logo
Published/Copyright: January 10, 2019
Radiochimica Acta
From the journal Radiochimica Acta Volume 107 Issue 4

Abstract

Experiments were performed to evaluate production of 72Se, parent radionuclide of the positron emitter 72As, at high energy at the Brookhaven Linac Isotope Producer (BLIP). Excitation functions for 75As(p, xn)72/75Se in the 52-105 MeV energy range were measured by irradiating thin gallium arsenide (GaAs) wafers. Maximum cross section value for the natAs(p, 4n)72Se reaction in the energy range was 103±9 mb at 52±1 MeV. Production size GaAs and arsenic metal (As°) targets were irradiated with 136 μA and 165 μA beam current possessing an initial Linac energy of 117 MeV. A total of 3.77±0.1 GBq (102±3 mCi) of 72Se was produced from a GaAs target at a calculated target entrance energy of 105.4 MeV, and 13.8±0.3 GBq (373±8 mCi) of 72Se from an As° target at a calculated incident energy of 49.5 MeV irradiated for 116.5 h and 68.9 h, respectively.

Keywords: As-72 generator; positron emission tomography; matched-pair; theragnostic; nuclear imaging; therapy

Funding source: Brookhaven National Laboratory

Award Identifier / Grant number: YN0100000

Funding source: National Science Foundation

Award Identifier / Grant number: DGE-0965983

Funding statement: This study was supported by funding provided by the Department of Energy, Office of Nuclear Physics, subprogram Production of High Specific Activity (Funder Id: http://dx.doi.org/10.13039/100006147, DE-ST001020) and Brookhaven National Laboratory Isotope LDRD/Program Development (Funder Id: http://dx.doi.org/10.13039/100006231, YN0100000). Trainee support is acknowledged from the National Science Foundation under IGERT award Funder Id: http://dx.doi.org/10.13039/100000001, DGE-0965983 (M.D. Gott and T.E. Phelps) and the Department of Energy Office of Science Graduate Student Research (SCGSR) award Funder Id: http://dx.doi.org/10.13039/100000015, DE-AC05-06OR23100 in 2014 (M. D. Gott) and 2015 (T.E. Phelps). The authors would also like to thank the Center for Functional Nanomaterials for its material analysis infrastructure related to thermal gravimetric analysis. A special thanks to Don Elliott from the instrumentation division at BNL for laser cutting GaAs targets, and the BLIP operator, TPL operators, quality assurance manager, and engineer (Jason Nalepa, Lisa Muench, Slawko Kurzak, Jack Eng, and Christian Cullen) involved with this project.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/ract-2018-2931).

Received: 2018-01-22
Accepted: 2018-12-06
Published Online: 2019-01-10
Published in Print: 2019-03-26

©2019 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Cross-section measurements and production of 72Se with medium to high energy protons using arsenic containing targets
  3. Thorium oxide dissolution in HNO3-HF mixture: kinetics and mechanism
  4. Highly efficient carbonaceous nanofiber/layered double hydroxide nanocomposites for removal of U(VI) from aqueous solutions
  5. Effect of solution acidity on the structure of amino acid-bearing uranyl compounds
  6. A novel method for the determination of uranium and free acidity in nuclear fuel process samples by extraction spectrophotometry
  7. Experimental investigation of photon attenuation parameters for different binary alloys
  8. Radiation protective characteristics of some selected tungstates
  9. New high temperature resistant heavy concretes for fast neutron and gamma radiation shielding
https://doi.org/10.1515/ract-2018-2931
Keywords for this article
As-72 generator; positron emission tomography; matched-pair; theragnostic; nuclear imaging; therapy

Articles in the same Issue

  1. Frontmatter
  2. Cross-section measurements and production of 72Se with medium to high energy protons using arsenic containing targets
  3. Thorium oxide dissolution in HNO3-HF mixture: kinetics and mechanism
  4. Highly efficient carbonaceous nanofiber/layered double hydroxide nanocomposites for removal of U(VI) from aqueous solutions
  5. Effect of solution acidity on the structure of amino acid-bearing uranyl compounds
  6. A novel method for the determination of uranium and free acidity in nuclear fuel process samples by extraction spectrophotometry
  7. Experimental investigation of photon attenuation parameters for different binary alloys
  8. Radiation protective characteristics of some selected tungstates
  9. New high temperature resistant heavy concretes for fast neutron and gamma radiation shielding
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