Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
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Valery Radchenko
Abstract
Targeted alpha therapy (TAT) is a treatment method of increasing interest to the clinical oncology community that utilizes α-emitting radionuclides conjugated to biomolecules for the selective killing of tumor cells. Proton irradiation of thorium generates a number of α-emitting radionuclides with therapeutic potential for application via TAT. In particular, the radionuclide 230Pa is formed via the 232Th(p, 3n) nuclear reaction and partially decays to 230U, an α emitter which has recently received attention as a possible therapy nuclide. In this study, we estimate production yields for 230Pa and other Pa isotopes from proton-irradiated thorium based on cross section measurements. We adopt existing methods for the chromatographic separation of protactinium isotopes from proton irradiated thorium matrices to combine and optimize them for effective fission product decontamination.
Acknowledgement
This work was supported by the United States Department of Energy, Office of Science, Office of Nuclear Physics, via funding from the Isotope Development and Production for Research and Applications subprogram. We also acknowledge funding support via the LANL-LDRD program through a Seaborg Institute Postdoctoral Fellowship. We are also very thankful for the technical assistance provided by Los Alamos National Laboratory's C-IIAC, MST-6, WNR and LANSCE-AOT groups.
©2016 Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
- Experimental determination of proton induced reaction cross sections on natNi near threshold energy
- Improved fluorimetric measurement of uranium uptake and distribution in spring wheat (Triticum aestivum L.)
- Radioactive 210Po in magnesium supplements
- Preclinical dosimetric estimation of [111In] 5, 10, 15, 20-tetra phenyl porphyrin complex as a possible imaging/PDT agent
- Development of 177Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent
- Radioiodination and biological evaluation of levalbuterol as a new selective radiotracer: a β2-adrenoceptor agonist
Artikel in diesem Heft
- Frontmatter
- Formation cross-sections and chromatographic separation of protactinium isotopes formed in proton-irradiated thorium metal
- Experimental determination of proton induced reaction cross sections on natNi near threshold energy
- Improved fluorimetric measurement of uranium uptake and distribution in spring wheat (Triticum aestivum L.)
- Radioactive 210Po in magnesium supplements
- Preclinical dosimetric estimation of [111In] 5, 10, 15, 20-tetra phenyl porphyrin complex as a possible imaging/PDT agent
- Development of 177Lu-DTPA-SPIO conjugates for potential use as a dual contrast SPECT/MRI imaging agent
- Radioiodination and biological evaluation of levalbuterol as a new selective radiotracer: a β2-adrenoceptor agonist
