Production of no-carrier-added 135La at an 18 MeV cyclotron and its purification for investigations at a concentration range down to 10−15 mol/L
-
Alexander Mansel
und
Karsten Franke
Abstract
The production of non-commercially available 135La by proton irradiation of an isotopically enriched [135Ba]BaCO3 target at a cyclotron is described. The purification of the radionuclide was performed by a La-selective resin. 135La was separated in no-carrier-added (n.c.a) form in a nitric acid solution with a radiochemical yield of 83 ± 5% and a total activity per batch of 43 ± 3 MBq. The enriched [135Ba]Ba was recycled to the carbonate form with a recovery of 90 ± 3%. On the basis of a detection limit of 1 Bq/mL, solutions of n.c.a. 135La could be measured down to the 10–15 mol/L concentration range.
Acknowledgement
We like to thank C. Schößler (HZDR) for the ICP-MS measurements and S. Gruhne (HZDR) for the mechanical manufacturing of the aluminium target system.
©2015 Walter de Gruyter Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Radiochemical determination of 129I and 36Cl in MEGAPIE, a proton irradiated lead-bismuth eutectic spallation target
- Production of no-carrier-added 135La at an 18 MeV cyclotron and its purification for investigations at a concentration range down to 10−15 mol/L
- New estradiol based 111In complex towards the estrogen receptor
- Radioiodination and biological evaluation of Cladribine as potential agent for tumor imaging and therapy
- Production, quality control, biodistribution assessment and preliminary dose evaluation of 166Ho-alendronate as a bone marrow ablative agent
- Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)
- Plutonium 241Pu in tissues and organs of Cervidae from Northern Poland
Artikel in diesem Heft
- Frontmatter
- Radiochemical determination of 129I and 36Cl in MEGAPIE, a proton irradiated lead-bismuth eutectic spallation target
- Production of no-carrier-added 135La at an 18 MeV cyclotron and its purification for investigations at a concentration range down to 10−15 mol/L
- New estradiol based 111In complex towards the estrogen receptor
- Radioiodination and biological evaluation of Cladribine as potential agent for tumor imaging and therapy
- Production, quality control, biodistribution assessment and preliminary dose evaluation of 166Ho-alendronate as a bone marrow ablative agent
- Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)
- Plutonium 241Pu in tissues and organs of Cervidae from Northern Poland
