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Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods

  • Tomasz R. Sosnowski ORCID logo EMAIL logo and Arkadiusz K. Kuczaj
Published/Copyright: April 2, 2025
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 10 Issue 4

Abstract

Pulmonary drug delivery (PDD) involves flow and deposition of aerosol particles acting as carriers of drugs delivered onto the surface of the airways. As a direct consequence, optimal PDD requires controlling of drug aerosolization processes and deep understanding of multiphase flows in complex geometry of the airways including aerosol particle dynamics during the transient inhalation cycles. A chemical engineering-based approache can be effectively used to analyze these processes and help in designing optimized drug formulations and more effective drug delivery devices (inhalers). One of prerequisites of improved PDD is the knowledge of in vivo–in vitro correlation (IVIVC) for inhaled drugs that would allow establishment of the relationships between aerosol quality determined using ex vivo methods (such as determination of particle size, deposition in reconstructed anatomical structures, pharmacokinetics/pharmacodynamics using in vitro cellular systems, or in silico modeling of aerosol dynamics) in connection to the clinical effects. This manuscript discusses the challenges of the IVIVC analyses for aerosol delivery systems. The primary focus is given to the physical and physicochemical constraints in the PDD that can be effectively described and investigated using engineering approaches.

Keywords: aerosols; inhaled medicines; inhalers; testing methods; computational analysis; IVIVC
Corresponding author: Tomasz R. Sosnowski, Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warynskiego 1, 00-645 Warsaw, Poland, E-mail:

Funding source: Collaboration Initiative Program between Warsaw Medical University and Warsaw University of Technology (Poland)

Award Identifier / Grant number: WUM_PW Integra

Acknowledgments

The authors would like to thank the editor David Bogle for his guidance and review of this article before its publication. The work has been done under umbrella of the scientific section “Chemical Engineering as Applied to Medicine” (ChemE-Med) of the European Federation of Chemical Engineering (EFCE).

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Both authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: T.R.S’s contribution was partially supported by WUM_PW Integra project under the Collaboration Initiative Program between Warsaw Medical University and Warsaw University of Technology.

  7. Data availability: Not applicable.

References

1. Newman, SP, Chan, H-K. In vitro/In vivo comparisons in pulmonary drug delivery. J Aerosol Med Pulm Drug Deliv 2008;21:77–84. https://doi.org/10.1089/jamp.2007.0643.Search in Google Scholar PubMed

2. Langer, R, Peppas, NA. A bright future in medicine for chemical engineering. Nat Chem Eng 2024;1:10–12. https://doi.org/10.1038/s44286-023-00016-y.Search in Google Scholar

3. Sosnowski, TR. Aerosols and human health – a multiscale problem. Chem Eng Sci 2023;268:118407. https://doi.org/10.1016/j.ces.2022.118407.Search in Google Scholar

4. Hickey, A, Kwok, PCL. In vitro-in vivo correlation of pharmaceutical aerosols. Adv Drug Deliv Rev 2021;179:114025. https://doi.org/10.1016/j.addr.2021.114025.Search in Google Scholar PubMed

5. Moreau, M, Simms, L, Andersen, ME, Trelles-Sticken, E, Wieczorek, R, Pour, SJ, et al.. Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next generation product aerosols. Front Toxicol 2024;6:1373325. https://doi.org/10.3389/ftox.2024.1373325.Search in Google Scholar PubMed PubMed Central

6. Suarez-Sharp, S, Li, M, Duan, J, Shah, H, Paul Seo, P. Regulatory experience with in vivo in vitro correlations (IVIVC) in new drug applications. AAPS J 2016;18:1379–90. https://doi.org/10.1208/s12248-016-9966-2.Search in Google Scholar PubMed

7. EPA. Exposure assessment tools by routes – inhalation [online]. https://www.epa.gov/expobox/exposure-assessment-tools-routes-inhalation [Accessed 20 Dec 2024].Search in Google Scholar

8. AARC. A guide to aerosol delivery devices for respiratory therapists [online]. https://www.aarc.org/wp-content/uploads/2015/04/aerosol_guide_rt.pdf [Accessed 20 Dec 2024].Search in Google Scholar

9. European Pharmacopeia. Chapter 2.9.18 preparations for inhalation: aerodynamic assessment of fine particles, 10th ed. Strasbourg: European Directorate for the Quality of Medicines and HealthCare (EDQM); 2021.Search in Google Scholar

10. Newman, SP, Chan, H-K. In vitro–in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation. Adv Drug Deliv Rev 2020;67:135–47. https://doi.org/10.1016/j.addr.2020.06.023.Search in Google Scholar PubMed

11. Kadota, K, Matsumoto, K, Uchiyama, H, Tobita, S, Maeda, M, Maki, D, et al.. In silico evaluation of particle transport and deposition in the airways of individual patients with chronic obstructive pulmonary disease. Eur J Pharm Biopharm 2022;174:10–19. https://doi.org/10.1016/j.ejpb.2022.03.010.Search in Google Scholar PubMed

12. Li, J, Zheng, H, Qin, L, Xu, E-Y, Yang, L, Zhang, L, et al.. In vitro–in vivo correlation of inhalable budesonide-loaded large porous particles for sustained treatment regimen of asthma. Acta Biomater 2019;96:505–16. https://doi.org/10.1016/j.actbio.2019.06.056.Search in Google Scholar PubMed

13. Sandell, D. Bioequivalence assessment of pharmaceutical aerosol products through IVIVC. Adv Drug Deliv Rev 2021;176:113895. https://doi.org/10.1016/j.addr.2021.113895.Search in Google Scholar PubMed

14. Di Ianni, E, Erdem, JS, Møller, P, Sahlgren, NM, Poulsen, SS, Knudsen, KB, et al.. In vitro–in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT. Part Fibre Toxicol 2021;18:25. https://doi.org/10.1186/s12989-021-00413-2.Search in Google Scholar PubMed PubMed Central

15. Kreutz, A, Chang, X, Hogberg, HT, Wetmore, BA. Advancing understanding of human variability through toxicokinetic modeling, in vitro–in vivo extrapolation, and new approach methodologies. Hum Genomics 2024;18:129. https://doi.org/10.1186/s40246-024-00691-9.Search in Google Scholar PubMed PubMed Central

16. Kolli, AR, Kuczaj, AK, Martin, F, Hayes, AW, Peitsch, MC, Hoeng, J. Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond. Crit Rev Toxicol 2019;49:725–41. https://doi.org/10.1080/10408444.2019.1692780.Search in Google Scholar PubMed

17. ICRP. Human respiratory tract model for radiological protection, Ottawa: ICRP Publication 66; 1994:1–3 pp, vol. 24.10.1016/0146-6453(94)90004-3Search in Google Scholar

18. Phalen, RF, Cuddihy, RG, Fisher, GL, Moss, OR, Schlesinger, RB, Swift, DL, et al.. Main features of the proposed NCRP respiratory tract model. Radiat Protect Dosim 1991;38:179–84. https://doi.org/10.1093/rpd/38.1-3.179.Search in Google Scholar

19. MPPD, Applied Research Associates, Inc.. Multiple-path particle Dosimetry model (MPPD v 3.04) [Online]. https://www.ara.com/mppd/[Accessed 20 Dec 2024].Search in Google Scholar

20. Laube, BL. Imaging aerosol deposition with two-dimensional gamma scintigraphy. J Aerosol Med Pulm Drug Deliv 2022;35:333–41. https://doi.org/10.1089/jamp.2022.29072.bll.Search in Google Scholar PubMed

21. Darquenne, C, Corcoran, TE, Lavorini, F, Sorano, A, Usmani, OS. The effects of airway disease on the deposition of inhaled drugs. Expert Opin Drug Deliv 2024;21:1175–90. https://doi.org/10.1080/17425247.2024.2392790.Search in Google Scholar PubMed PubMed Central

22. Yeh, HC, Schum, GM. Models of the human lung airways and their application to inhaled particle deposition. Bull Math Biol 1980;42:461–80. https://doi.org/10.1007/bf02460796.Search in Google Scholar

23. Byron, PA. Factors affecting aerosol sampling 2016 [Online]. https://www.cdc.gov/niosh/docs/2014-151/pdfs/chapters/chapter-ae.pdf [Accessed 20 Dec 2024].Search in Google Scholar

24. Cheng, YS. Aerosol deposition in the extrathoracic region. Aerosol Sci Technol 2003;37:659–71. https://doi.org/10.1080/02786820300906.Search in Google Scholar PubMed PubMed Central

25. Cheng, YS, Zhou, Y, Chen, BT. Particle deposition in a cast of human oral airways. Aerosol Sci Tech 1999;31:286–300. https://doi.org/10.1080/027868299304165.Search in Google Scholar

26. Sosnowski, TR. Inhaled aerosols: their role in COVID-19 transmission including biophysical interactions in the lungs. Curr Opin Coll Interf Sci 2021;54:101451. https://doi.org/10.1016/j.cocis.2021.101451.Search in Google Scholar PubMed PubMed Central

27. Martin, AR, Finlay, WH. Nebulizers for drug delivery to the lungs. Expert Opin Drug Deliv 2015;12:889–900. https://doi.org/10.1517/17425247.2015.995087.Search in Google Scholar PubMed

28. Tashkin, DP. A review of nebulized drug delivery in COPD. Int J Chronic Obstruct Pulm Dis 2016;11:2585–96. https://doi.org/10.2147/copd.s114034.Search in Google Scholar PubMed PubMed Central

29. McCallion, ON, Taylor, KM, Thomas, M, Taylor, AJ. Nebulization of fluids of different physicochemical properties with air‐jet and ultrasonic nebulizers. Pharm Res (N Y) 1995;12:1682–8. https://doi.org/10.1023/a:1016205520044.10.1023/A:1016205520044Search in Google Scholar PubMed

30. Ghazanfari, T, Elhissi, AMA, Ding, Z, Taylor, KMG. The influence of fluid physicochemical properties on vibrating‐mesh nebulization. Int J Pharmacol 2007;339:103–11. https://doi.org/10.1016/j.ijpharm.2007.02.035.Search in Google Scholar PubMed

31. Beck-Broichsitter, M, Oesterheld, N, Knuedeler, M -C, Seeger, W, Schmeh, IT. On the correlation of output rate and aerodynamic characteristics in vibrating-mesh-based aqueous aerosol delivery. Int J Pharm 2014;461:34–7. https://doi.org/10.1016/j.ijpharm.2013.11.036.Search in Google Scholar PubMed

32. Dobrowolska, K, Emeryk, A, Janeczek, K, Krzosa, R, Pirożyński, M, Sosnowski, TR. Influence of physicochemical properties of budesonide micro‐suspensions on their expected lung delivery using a vibrating mesh nebulizer. Pharmaceutics 2023;15:752. https://doi.org/10.3390/pharmaceutics15030752.Search in Google Scholar PubMed PubMed Central

33. ISO. ISO 27427:2023, Anaesthetic and respiratory equipment – nebulizing systems and components, 2023 [Online]. https://www.iso.org/standard/78542.html [Accessed 2024 Dec 2024].Search in Google Scholar

34. Dobrowolska, KE, Kinowska, M, Sosnowski, TR. Nebulization of solutions containing guar gum as a viscosity modifier of natural origin. In: Respiratory drug delivery. Richmond, VA, USA: RDD Online; 2022.Search in Google Scholar

35. Dobrowolska, K, Miros, M, Sosnowski, T. Impact of natural-based viscosity modifiers of inhalation drugs on the dynamic surface properties of the pulmonary surfactant. Materials 2023;16:1975. https://doi.org/10.3390/ma16051975.Search in Google Scholar PubMed PubMed Central

36. EMA. CHMP, Guideline on the pharmaceutical quality of inhalation and nasal products, 2005 [Online]. https://www.ema.europa.eu/en/pharmaceutical-quality-inhalation-nasal-products-scientific-guideline [Accessed 20 Dec 2024].Search in Google Scholar

37. Sosnowski, TR. Towards more precise targeting of inhaled aerosols to different areas of the respiratory system. Pharmaceutics 2024;16:97. https://doi.org/10.3390/pharmaceutics16010097.Search in Google Scholar PubMed PubMed Central

38. Sosnowski, TR, Janeczek, K, Grzywna, K, Emeryk, A. Mass and volume balances of nebulization processes for the determination of the expected dose of liquid medicines delivered by inhalation. Chem Process Eng 2021;42:253–61.Search in Google Scholar

39. Laube, BL, Janssens, HM, de Jongh, FHC, Devadason, SG, Dhand, R, Diot, P, et al.. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J 2011;37:1308–417. https://doi.org/10.1183/09031936.00166410.Search in Google Scholar PubMed

40. Dorosz, A, Moskal, A, Sosnowski, TR. Dynamics of aerosol generation and flow during inhalation for improved in vitro–in vivo correlation (IVIVC) of pulmonary medicines. Chem Process Eng: New Front 2023;44:e39.10.24425/cpe.2023.147398Search in Google Scholar

41. Zhou, Y, Ahuja, A, Irvin, CM, Kracko, DA, McDonald, JD, Cheng, YS. Medical nebulizer performance: effects of cascade impactor temperature. Respir Care 2005;50:1077–82.Search in Google Scholar

42. Berg, E, Svensson, JO, Asking, L. Determination of nebulizer droplet size distribution: a method based on impactor refrigeration. J Aerosol Med 2007;20:97–104. https://doi.org/10.1089/jam.2007.0556.Search in Google Scholar PubMed

43. Schuschnig, U, Heine, B, Knoch, M. How cold is cold enough? Refrigeration of the Next-Generation Impactor to prevent aerosol undersizing. J Aerosol Med Pulm Drug Deliv 2022;35:25–31. https://doi.org/10.1089/jamp.2021.0015.Search in Google Scholar PubMed PubMed Central

44. Mao, L, Wilcox, D, Kippax, P. Laser diffraction particle size analysis: a powerful tool for rapidly screening nebulizer formulations. Drug Deliv Techn 2010;10:64–7.Search in Google Scholar

45. Sosnowski, TR. Critical assessment of the quantitative criteria used in the comparison of nebulizers. EC Pulm Respirat Med 2019;8:656–62.Search in Google Scholar

46. Kostrzon, M, Sliwka, A, Wloch, T, Szpunar, M, Ankowska, D, Nowobilski, R. Subterranean pulmonary rehabilitation in chronic obstructive pulmonary disease. Adv Exp Med Biol 2019;1176:35–46. https://doi.org/10.1007/5584_2019_354.Search in Google Scholar PubMed

47. Sosnowski, TR, Koprowski, M. Nebulization in the subterranean conditions: the influence of ambient conditions on the generation of aerosols for inhalation. In: Chemical and process engineering for environment and health. Current status in 2024. Radom, Poland: Łukasiewicz Institute for Sustainable Technologies; 2024:136–43 pp.Search in Google Scholar

48. Copley, M, Mitchell, J, Solomon, D. Evaluating of Alberta Throat: an innovation to support the acquisition of more clinically applicable aerosol aerodynamic particle size distribution (APSD) data in oral inhaled product (OIP) development. Inhalation 2011;5:12.Search in Google Scholar

49. Copley, M, Parry, M, Solomon, D, Mitchell, J. Comparison between in vitro performance of the Child “Alberta” Idealized Throat and Ph.Eur./USP induction port for the delivery of salbutamol sulfate inhalation aerosol by pressurized metered dose inhaler. Inhalation 2015;1:3.Search in Google Scholar

50. Kramek-Romanowska, K, Odziomek, M, Sosnowski, TR, Gradoń, L. Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation. Ind Eng Chem Res 2011;50:13922–31. https://doi.org/10.1021/ie2006998.Search in Google Scholar

51. Gradoń, L, Sosnowski, TR. Formation of particles for dry powder inhalers. Adv Powder Technol 2014;25:43–55. https://doi.org/10.1016/j.apt.2013.09.012.Search in Google Scholar

52. Kadota, K, Sosnowski, TR, Tobita, S, Tachibana, I, Tse, J, Uchiyama, K, et al.. A particle technology approach toward designing dry-powder inhaler formulations for personalized medicine in respiratory diseases. Adv Powder Technol 2020;31:219–26. https://doi.org/10.1016/j.apt.2019.10.013.Search in Google Scholar

53. Dorosz, A, Urbankowski, T, Zieliński, K, Michnikowski, M, Krenke, R, Moskal, A. Modeling of inhalation profiles through dry powder inhaler in healthy adults and asthma patients as a prerequisite for further in vitro and in silico studies. J Aerosol Med Pulm Drug Delivery 2022;35:91–103. https://doi.org/10.1089/jamp.2021.0021.Search in Google Scholar PubMed

54. Sanchis, J, Gich, I, Pedersen, S. Systematic review of errors in inhaler use. Has patient technique improved over time? Chest 2016;150:394–406. https://doi.org/10.1016/j.chest.2016.03.041.Search in Google Scholar PubMed

55. GINA. The global initiative for asthma [Online]. http://ginasthma.org [Accessed 20 Dec 2024].Search in Google Scholar

56. Stapleton, KW, Guntsch, E, Hoskinson, MK, Finlay, WH. On the suitability of k-eps turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment. J Aerosol Sci 2000;31:739–49.10.1016/S0021-8502(99)00547-9Search in Google Scholar

57. Heenan, AF, Matida, E, Pollard, A, Finlay, WH. Experimental measurements and computational modeling of flow in an idealized extrathoracic airway. Exp Fluids 2003;35:70–84. https://doi.org/10.1007/s00348-003-0636-7.Search in Google Scholar

58. Carrigy, NB, Ruzycki, CA, Golshahi, L, Finlay, WH. Pediatric in vitro and in silico models of deposition via oral and nasal inhalation. J Aerosol Med Pulm Drug Deliv 2014;27:149–69. https://doi.org/10.1089/jamp.2013.1075.Search in Google Scholar PubMed

59. Zhang, Y, Finlay, WH, Matida, EA. Particle deposition measurements and numerical simulation in a highly idealized mouth-throat. J Aerosol Sci 2004;35:789–803. https://doi.org/10.1016/j.jaerosci.2003.12.006.Search in Google Scholar

60. Copley Scientific Limited. Realistic throat and nasal cast models [Online]. https://www.copleyscientific.com/inhaler-testing/realistic-throat-and-nasal-models/alberta-idealised-nasal-inlet-aini/[Accessed 20 Dec 2024].Search in Google Scholar

61. Grgic, B, Finlay, WH, Burnell, PKP, Heenan, A. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J Aerosol Sci 2004;35:1025–40. https://doi.org/10.1016/j.jaerosci.2004.03.003.Search in Google Scholar

62. Sosnowski, TR, Moskal, A, Gradoń, L. Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern. Inhal Toxicol 2006;18:773–80. https://doi.org/10.1080/08958370600748737.Search in Google Scholar PubMed

63. Sosnowski, TR, Rapiejko, P, Sova, J, Dobrowolska, K. Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model. Int J Pharm 2020;574:118911. https://doi.org/10.1016/j.ijpharm.2019.118911.Search in Google Scholar PubMed

64. Taube, C, Kanniess, F, Grönke, L, Richter, K, Mücke, M, Paasch, K, et al.. Reproducibility of forced inspiratory and expiratory volumes after bronchodilation in patients with COPD or asthma. Respir Med 2003;97:568–77. https://doi.org/10.1053/rmed.2001.1411.Search in Google Scholar PubMed

65. Pirożyński, M, Sosnowski, TR. Inhalation devices: from basic science to practical use, innovative vs generic products. Expert Opin Drug Del 2016;13:1559–71. https://doi.org/10.1080/17425247.2016.1198774.Search in Google Scholar PubMed

66. Taki, M, Esmaeili, F, Martin, GP. The scientific basis and challenges of combination inhaled products. J Drug Deliv Sci Technol 2011;21:293–300. https://doi.org/10.1016/s1773-2247(11)50046-2.Search in Google Scholar

67. Hejduk, A, Urbańska, A, Osiński, A, Łukaszewicz, P, Domański, M, Sosnowski, TR. Technical challenges in obtaining an optimized powder/DPI combination for inhalation delivery of a bi-component generic drug. J Drug Deliv Sci Technol 2018;44:406–14. https://doi.org/10.1016/j.jddst.2018.01.019.Search in Google Scholar

68. Kikidis, D, Konstantinos, V, Tzovaras, D, Usmani, OS. The digital asthma patient: the history and future of inhaler based health monitoring devices. J Aerosol Med Pulm Drug Deliv 2016;29:219–32. https://doi.org/10.1089/jamp.2015.1267.Search in Google Scholar PubMed

69. Lucci, F, Frederix, E, Kuczaj, AK. AeroSolved: computational fluid dynamics modeling of multispecies aerosol flows with sectional and moment methods. J Aerosol Sci 2022;159:105854. https://doi.org/10.1016/j.jaerosci.2021.105854.Search in Google Scholar

70. AeroSolved. CFD software package [Online]. https://github.com/pmpsa-cfd/aerosolved [Accessed 20 Dec 2024].Search in Google Scholar

71. Sosnowski, TR. Particles on the lung surface – physicochemical and hydrodynamic effects. Curr Opin Colloid Interface Sci 2018;36:1–9. https://doi.org/10.1016/j.cocis.2017.12.003.Search in Google Scholar

72. Odziomek, M, Kalinowska, M, Płuzińska, A, Rożeń, A, Sosnowski, TR. Bronchial mucus as a complex fluid: molecular interactions and influence of nanostructured particles on rheological and transport properties. Chem Process Eng 2017;38:217–29. https://doi.org/10.1515/cpe-2017-0017.Search in Google Scholar

73. Francis, I, Shrestha, J, Raj Paudel, K, Hansbro, PM, Ebrahimi-Warkiani, M, Saha, SC. Recent advances in lung-on-a-chip models. Drug Discov Today 2022;27:2593–602. https://doi.org/10.1016/j.drudis.2022.06.004.Search in Google Scholar PubMed

74. Zamprogno, P, Wüthrich, S, Achenbach, S, Thoma, G, Stucki, JD, Hobi, N, et al.. Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane. Commun Biol 2021;4:168. https://doi.org/10.1038/s42003-021-01695-0.Search in Google Scholar PubMed PubMed Central

75. Sosnowski, TR, Podgórski, A. Assessment of the pulmonary toxicity of inhaled gases and particles with physicochemical methods. Int J Occup Saf Ergon. 1999;5:433–49. https://doi.org/10.1080/10803548.1999.11076430.Search in Google Scholar PubMed

76. Sosnowski, TR, Jabłczyńska, K, Odziomek, M, Schlage, WK, Kuczaj, AK. Physicochemical studies of direct interactions between lung surfactant and components of electronic cigarettes liquid mixtures. Inhal Toxicol 2018;30:159–68. https://doi.org/10.1080/08958378.2018.1478916.Search in Google Scholar PubMed

77. Solass, W, Kerb, R, Mürdter, T, Giger-Pabst, U, Strumberg, D, Tempfer, CZJ, et al.. Intraperitoneal chemotherapy of peritoneal carcinomatosis using pressurized aerosol as an alternative to liquid solution: first evidence for efficacy. Ann Surg Oncol 2014;21:553–9. https://doi.org/10.1245/s10434-013-3213-1.Search in Google Scholar PubMed PubMed Central

Received: 2025-01-08
Accepted: 2025-01-23
Published Online: 2025-04-02

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods
  4. Analysis of an automated solar panel cleaning robot on photovoltaics (PV) module frames with composites materials
  5. Mechanical and thermal properties of graphene reinforced poly (lactic acid) composites for battery casing in electric vehicles
  6. Precision medicine in hypothyroidism: an engineering approach to individualized levothyroxine dosing
  7. Advancements in composite materials for energy harvesting
  8. Model-based dose selection for gene therapy for haemophilia B
https://doi.org/10.1515/psr-2024-0054
Keywords for this article
aerosols; inhaled medicines; inhalers; testing methods; computational analysis; IVIVC

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods
  4. Analysis of an automated solar panel cleaning robot on photovoltaics (PV) module frames with composites materials
  5. Mechanical and thermal properties of graphene reinforced poly (lactic acid) composites for battery casing in electric vehicles
  6. Precision medicine in hypothyroidism: an engineering approach to individualized levothyroxine dosing
  7. Advancements in composite materials for energy harvesting
  8. Model-based dose selection for gene therapy for haemophilia B
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