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Research and functionalization of konjac glucomannan and its hydrogel in wound dressing

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Published/Copyright: December 25, 2024
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Journal of Polymer Engineering
From the journal Journal of Polymer Engineering Volume 45 Issue 1

Abstract

In the last decade, polysaccharide dressings have become a popular research area owing to their low toxicities, good biocompatibilities, and their abilities to modulate and accelerate wound healing. Konjac glucomannan (KGM) is a naturally occurring, neutral polysaccharide that is biocompatible and highly modifiable. In addition, KGM-based hydrogels are innovative wound dressings that effectively promote the healing of injured blood vessels and wound fibres. In this review, we summarise how KGM has been modified and used in hydrogel wound-dressing applications, starting with its material properties and gelation mechanism. We then discuss recent advances in the study of systems for enhancing KGM hydrogels and KGM hydrogel wound dressings, emphasising the special benefits of such hydrogels in terms of antimicrobial and anti-inflammatory properties, their wound-healing capabilities, as drug carriers and growth promoters, as well as their functionalisation. Finally, this paper discusses the primary obstacles and potential avenues for the advancement of wound dressings with the aim of establishing a theoretical foundation and point of reference for future research into KGM functional materials.

Keywords: konjac glucomannan; hydrogel; wound dressing
Corresponding author: Yanjun Li, School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China, E-mail:

Funding source: National Key Research and Development Program of China

Award Identifier / Grant number: 2022YFD1602000

Funding source: Key Research and Development Projects of Shaanxi Province

Award Identifier / Grant number: 2023-XCZX-03

Award Identifier / Grant number: 2023GXLH-075

Funding source: Shaanxi Province Qinchuangyuan “scientist + engineer” team construction project

Award Identifier / Grant number: 2023KXJ-239

Funding source: Engineering Research Center of Major Infectious Disease Therapeutics, Universities of Shaanxi Province

Acknowledgments

The authors acknowledge individuals, working groups, institutions, etc. who provided help and support (other than financial) during research and the preparation of the manuscript.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Jingwen Shen: conceptualization (lead); data curation(equal); writing-original draft (lead) formal analysis (lead); writing review & editing (lead). Yanjun Li: supervision (equal); validation (lead); funding acquisition (lead). Donglan Yong: investigation (equal); methodology (equal). Yizhen Tang: methodology (equal); resources (equal). Yong Wang: funding acquisition (equal).

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interests: The authors state no conflict of interest.

  6. Research funding: This work was supported by the national key research and development program (The integration and demonstration of key technologies of characteristic cash crops, fruit, and vegetable industry in Qinba Mountain area of Shaanxi Province, Project no. 2022YFD1602000); the Shaanxi Province Qinchuangyuan “scientist + engineer” team construction project (2023KXJ-239); the Shaanxi Pro-vincial Key Research and Development Program (2023-XCZX-03, 2023GXLH-075); and the Engineering Research Center of Major Infectious Disease Therapeutics, Universities of Shaanxi Province.

  7. Data availability: Not applicable.

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Received: 2024-07-05
Accepted: 2024-10-11
Published Online: 2024-12-25
Published in Print: 2025-01-29

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Material Properties
  3. Magnetic metal oxide assisted conducting polymer nanocomposites as eco-friendly electrode materials for supercapacitor applications: a review
  4. Effects of different ratios of soft and rigid segment on the properties of soil and sand fixing materials of polyacrylate
  5. Research on the impact of active calcium carbonate on the performance of degradable composite films
  6. Research and functionalization of konjac glucomannan and its hydrogel in wound dressing
  7. Preparation and Assembly
  8. Acryloyl starch/carboxymethyl cellulose grafting copolymerization composite hydrogel for efficient adsorption of methylene blue
  9. Preparation and anti-fouling behavior of conductive and hydrophilic polypyrrole modified PVDF composite membrane
  10. Engineering and Processing
  11. Gas assisted fused deposition modeling: effects of assist gas parameters on print quality and properties
  12. Remediation of Ni2+ and Sr2+ ions from aqueous solutions by acacia gum/polyacrylic acid hydrogel reinforced with TiO2 nanoparticles
https://doi.org/10.1515/polyeng-2024-0132
Keywords for this article
konjac glucomannan; hydrogel; wound dressing

Articles in the same Issue

  1. Frontmatter
  2. Material Properties
  3. Magnetic metal oxide assisted conducting polymer nanocomposites as eco-friendly electrode materials for supercapacitor applications: a review
  4. Effects of different ratios of soft and rigid segment on the properties of soil and sand fixing materials of polyacrylate
  5. Research on the impact of active calcium carbonate on the performance of degradable composite films
  6. Research and functionalization of konjac glucomannan and its hydrogel in wound dressing
  7. Preparation and Assembly
  8. Acryloyl starch/carboxymethyl cellulose grafting copolymerization composite hydrogel for efficient adsorption of methylene blue
  9. Preparation and anti-fouling behavior of conductive and hydrophilic polypyrrole modified PVDF composite membrane
  10. Engineering and Processing
  11. Gas assisted fused deposition modeling: effects of assist gas parameters on print quality and properties
  12. Remediation of Ni2+ and Sr2+ ions from aqueous solutions by acacia gum/polyacrylic acid hydrogel reinforced with TiO2 nanoparticles
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