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Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly(vinyl alcohol) hybrids

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Veröffentlicht/Copyright: 3. Februar 2015
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Journal of Polymer Engineering
Aus der Zeitschrift Journal of Polymer Engineering Band 35 Heft 6

Abstract

Zinc oxide (ZnO) nanoparticles possess antibacterial properties. Being less toxic to humans than silver, they are attractive as antibacterial agents in biomedical applications. In this study, we focus on the influence of the size of ZnO nanoparticles on their antibacterial action against strains of three bacteria: one Gram-negative, Escherichia coli and two Gram-positive, Bacillus subtilis and Staphylococcus aureus. The antibacterial efficacy of the nanoparticles increases with decreasing particle size. A major contributor to antibacterial action is the oxidative stress induced by the ZnO. To understand the relationship between antibacterial action and induced oxidative stress, we measured the dependence of the nanoparticle diameter on H2O2 concentration. Even at a fixed nanoparticle concentration, the H2O2 concentration increased with decreasing nanoparticle diameter. This is qualitatively similar to the dependence of the antibacterial activity on the nanoparticle diameter. In addition, in the presence of ZnO nanoparticles, we detected increased quantities of endogenous H2O2 in the E. coli. For use as antibacterial wound dressings, we fabricated nonwoven fiber mats from poly(vinyl alcohol) (PVA)/ZnO nanoparticle suspensions. The antibacterial efficacy of the PVA/ZnO electrospun fiber mats also increased with a decrease in the diameter and an increase in the concentration of the ZnO nanoparticles.

Keywords: antibacterial activity; electrospinning; poly(vinyl alcohol); wound dressing; ZnO nanoparticles
Corresponding authors: Sathish K. Sukumaran and Masataka Sugimoto, Graduate School of Science and Engineering, Yamagata University, Yonezawa, 992-8510, Japan, e-mail: ,

Acknowledgments

This work was partially supported by JSPS KAKENHI Grant no. 23655209. TJ would like to acknowledge the support from the Sagawa International Student Scholarship Foundation. Part of this work was undertaken when SKS was supported by the Dissemination of Tenure Tracking System Program of Ministry of Education, Culture, Sports, Science and Technology, Japan. We gratefully acknowledge Dr. Yuji Aoki and Dr. Toshinori Makuta of Yamagata University for helpful discussions and the latter for the use of instrumental facilities. We are also especially grateful to an anonymous referee for insightful comments that led to improvements in the manuscript.

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Received: 2014-10-29
Accepted: 2014-12-10
Published Online: 2015-2-3
Published in Print: 2015-8-1

©2015 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Original articles
  3. Preparation and application of fluorinated-siloxane protective surface coating material for stone inscriptions
  4. The effect of the preparation process on the swelling behavior of silk fibroin-polyurethane composite hydrogels using a full factorial experimental design
  5. Synthesis of cashew Mannich polyol via a three step continuous route and development of PU rigid foams with mechanical, thermal and fire studies
  6. Effect of chemical treatment on the mechanical and water absorption properties of bagasse fiber-reinforced epoxy composites
  7. Environmentally degradable sago starch filled low-density polyethylene
  8. The effect of hybrid nanoparticle with silica sol as the supporter on the crystallization behavior and mechanical properties of isotactic polypropylene
  9. Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly(vinyl alcohol) hybrids
  10. Nanofiber formation in the presence of an external magnetic field in electrospinning
  11. Preparation and characterization emulsion of PANI-TiO2 nanocomposite and its application as anticorrosive coating
  12. The effect of the geometry of extrusion head flow channels on the adiabatic extrusion of low density polyethylene
https://doi.org/10.1515/polyeng-2014-0319
Schlagwörter für diesen Artikel
antibacterial activity; electrospinning; poly(vinyl alcohol); wound dressing; ZnO nanoparticles

Artikel in diesem Heft

  1. Frontmatter
  2. Original articles
  3. Preparation and application of fluorinated-siloxane protective surface coating material for stone inscriptions
  4. The effect of the preparation process on the swelling behavior of silk fibroin-polyurethane composite hydrogels using a full factorial experimental design
  5. Synthesis of cashew Mannich polyol via a three step continuous route and development of PU rigid foams with mechanical, thermal and fire studies
  6. Effect of chemical treatment on the mechanical and water absorption properties of bagasse fiber-reinforced epoxy composites
  7. Environmentally degradable sago starch filled low-density polyethylene
  8. The effect of hybrid nanoparticle with silica sol as the supporter on the crystallization behavior and mechanical properties of isotactic polypropylene
  9. Towards novel wound dressings: antibacterial properties of zinc oxide nanoparticles and electrospun fiber mats of zinc oxide nanoparticle/poly(vinyl alcohol) hybrids
  10. Nanofiber formation in the presence of an external magnetic field in electrospinning
  11. Preparation and characterization emulsion of PANI-TiO2 nanocomposite and its application as anticorrosive coating
  12. The effect of the geometry of extrusion head flow channels on the adiabatic extrusion of low density polyethylene
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