Study on the effective ablation volume of microwave ablation of porcine livers: Untersuchungen zum effektiven Ablationsvolumen bei Mikrowellen-Ablation am Lebermodell (Schwein)

Guangxia Hu; Zhiyu Qian; Shangwen Ding; Ye Zhang; Jieru Xie

doi:10.1515/plm-2012-0039

Article

Study on the effective ablation volume of microwave ablation of porcine livers

Untersuchungen zum effektiven Ablationsvolumen bei Mikrowellen-Ablation am Lebermodell (Schwein)

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Published/Copyright: April 11, 2013

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From the journal Photonics & Lasers in Medicine Volume 2 Issue 3

Abstract:

This paper reports on an effective ablation volume model for microwave ablation of porcine liver. Firstly, in order to obtain the temperature field distribution, a theoretical simulation model of the microwave ablation of porcine liver was developed by solving Pennes bioheat transfer equation using the COMSOL Multiphysics software. Then the effective ablation volume and the effective ablation volume model were obtained using the 1stOpt fitting software by 7D-Soft High Technology Inc. (China). Finally, microwave ablation experiments were carried out using porcine liver to verify the accuracy and effectiveness of the model. The results show that according to the ablation volume model, one can determine the scope of the effective ablation under varying conditions of microwave power and duration. This provides an important basis for the preoperative planning system of microwave ablation.

Zusammenfassung:

Die vorliegende Arbeit berichtet über ein effektives Ablationsvolumen-Modell für die Mikrowellenablation von Schweineleber. Zuerst wurde ein theoretisches Simulationsmodell durch Lösen der Bio-Wärmetransfer-Gleichung von Pennes unter Verwendung der COMSOL Multiphysics Software entwickelt, um die Temperatur-Feldverteilung in Schweineleber zu ermitteln. Danach wurde das effektive Ablationsvolumen durch ein Ablationsvolumen-Modell unter Verwendung der 1stOpt Fitting-Software (7D-Soft High Technology Inc., China) bestimmt. Schließlich wurden Mikrowellenablations-Experimente mit Schweineleber durchgeführt, um die Genauigkeit und Effektivität des Modells zu überprüfen. Die Ergebnisse zeigen, dass unter Zugrundelegung des Ablationsvolumen-Modells der Umfang der effektiven Ablation unter variierenden Bedingungen von Mikrowellenleistung und Applikationsdauer bestimmt werden kann. Dies stellt eine wichtige Grundlage für ein präoperatives Planungssystem der Mikrowellenablation dar.

Keywords: microwave ablation; effective ablation volume; temperature field; Pennes bioheat transfer equation; COMSOL Multiphysics; Mikrowellenablation; effektives Ablationsvolumen; Temperaturfeld; Bio-Wärmetransfer-Gleichung von Pennes

Corresponding author: Zhiyu Qian, Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, No. 29 Yudao Street, Nanjing, Jiangsu, 210016, China

This work was carried out in the Biophotonics Laboratory in the University of Aeronautics and Astronautics and was financially supported by Specialized Research Fund for the Doctoral Program of Higher Education (20103218110012), Jiangsu Key Technology R&D Program (BE2010729), and Funding of Jiangsu Innovation Program for Graduate Education (CXZZ11_0202) and NUAA Research Funding (1003-56XNA 12032).

References

[1] Dong BW, Liang P. Thermal ablation of tumor: status and prospects. Natl Med J China 2006;86(12):793–6.Search in Google Scholar

[2] Mirza AN, Fornage BD, Sneige N, Kuerer HM, Newman LA, Ames FC, Singletary SE. Radiofrequency ablation of solid tumors. Cancer J 2001;7(2): 95–102.Search in Google Scholar

[3] Carey RI, Leveillee RJ. First prize: direct real-time temperature monitoring for laparoscopic and CT-guided radiofrequency ablation of renal tumors between 3 and 5 cm. J Endourol 2007;21(8): 807–13.10.1089/end.2007.9943Search in Google Scholar PubMed

[4] de Senneville BD, Mougenot C, Quesson B, Dragonu I, Grenier N, Moonen CT. MR thermometry for monitoring tumor ablation. Eur Radiol 2007;17(9):2401–10.10.1007/s00330-007-0646-6Search in Google Scholar PubMed

[5] Kickhefel A, Roland J, Weiss C, Schick F. Accuracy of real-time MR temperature mapping in the brain: a comparison of fast sequences. Phys Med 2010;26(4):192–201.10.1016/j.ejmp.2009.11.006Search in Google Scholar PubMed

[6] Li KY, Dong YG, Chen C, Zhang SP. The noninvasive reconstruction of 3D temperature field in a biological body with Monte Carlo method. J Neurocomputing 2008;72(1–3):128–33.10.1016/j.neucom.2008.03.016Search in Google Scholar

[7] Liang P, Dong B, Yu X, Yu D, Cheng Z, Su L, Peng J, Nan Q, Wang H. Computer-aided dynamic simulation of microwave-induced thermal distribution in coagulation of liver cancer. IEEE Trans Biomed Eng 2001;48(7):821–9.10.1109/10.930907Search in Google Scholar PubMed

[8] Liu FY. Master thesis: 915 MHz microwave ablation with cooled-shaft antennae: experimental study of computer-simulated three-dimensional thermal field and clinical application study. Chinese PLA Postgraduate Medical School Beijing; 2009. http://www.dissertationtopic.net/doc/519128 [Accessed on November 5, 2012].Search in Google Scholar

[9] Keangin P, Rattanadecho P, Wessapan T. An analysis of heat transfer in liver tissue during microwave ablation using single and double slot antenna. Int Commun Heat Mass 2011;38(6):757–66.10.1016/j.icheatmasstransfer.2011.03.027Search in Google Scholar

[10] Ma L, Paul DL, Pothecary N, Railton C, Bows J, Barratt L, Mullin J, Simons D. Experimental validation of a combined electromagnetic and thermal FDTD model of a microwave heating process. IEEE T Microw Theory 1995;43(11):2565–72.10.1109/22.473179Search in Google Scholar

[11] Elizeh BG, Ladtkow C, Podhajsky RJ. The decoupling of coupled computer simulations of radio frequency thermal therapy in tissue. Proc SPIE 2007;6440. doi:10.1117/12.702176.10.1117/12.702176Search in Google Scholar

[12] Keangin P, Wessapan T, Rattanadecho P. Analysis of heat transfer in deformed liver cancer modeling treated using a microwave coaxial antenna. Appl Therm Eng 2011;31(16): 3243–54.10.1016/j.applthermaleng.2011.06.005Search in Google Scholar

[13] Barauskas R, Gulbinas A, Vanagas T, Barauskas G. Finite element modeling of cooled-tip probe radiofrequency ablation processes in liver tissue. Comput Biol Med 2008;38(6): 694–708.10.1016/j.compbiomed.2008.03.007Search in Google Scholar PubMed

[14] Bao MF, Qian ZY, Li WT, Xiao DI, Wang JY, Quian L. Biological tissue’s temperature field during the laser-induced interstitial thermotherapy. Acta Photonica Sinica 2011;40(5):718–21.10.3788/gzxb20114005.0718Search in Google Scholar

[15] Müller G, Roggan A, editors. Laser-induced interstitial thermotherapy. Bellingham: SPIE Press; 1995.Search in Google Scholar

[16] Yu J, Liang P, Yu X, Liu F, Chen L, Wang Y. A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: results in ex vivo and in vivo porcine livers. Eur J Radiol 2011;79(1):124–30.10.1016/j.ejrad.2009.12.009Search in Google Scholar PubMed

[17] Yu J, Liang P, Yu X, Wang Y, Gao Y. Ultrasound-guided percutaneous microwave ablation of splenic metastasis: report of four cases and literature review. Int J Hyperthermia 2011;27(5):517–22.10.3109/02656736.2011.563768Search in Google Scholar PubMed

[18] Cheng Z, Xiao Q, Wang Y, Sun Y, Lu T, Liang P. 915MHz microwave ablation with implanted internal cooled-shaft antenna: initial experimental study in in vivo porcine livers. Eur J Radiol 2011;79(1):131–5.10.1016/j.ejrad.2009.12.013Search in Google Scholar PubMed

Erhalten: 2012-9-9

Revidiert: 2013-2-13

Angenommen: 2013-2-26

Online erschienen: 2013-4-11

Erschienen im Druck: 2013-8-1

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Articles in the same Issue

https://doi.org/10.1515/plm-2012-0039

Keywords for this article

microwave ablation; effective ablation volume; temperature field; Pennes bioheat transfer equation; COMSOL Multiphysics; Mikrowellenablation; effektives Ablationsvolumen; Temperaturfeld; Bio-Wärmetransfer-Gleichung von Pennes