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The quantum chemistry revolution and the instrumental revolution as evidenced by the Nobel Prizes in chemistry

  • Jeffrey I. Seeman ORCID logo EMAIL logo
Veröffentlicht/Copyright: 6. August 2025
Pure and Applied Chemistry
Aus der Zeitschrift Pure and Applied Chemistry

Abstract

The International Year of Quantum Science and Technology (IYQ) publicizes and celebrates the centenary of quantum mechanics (QM). In this essay, I demonstrate that the assemblage of 17 Nobel Prizes in Chemistry awarded since 1960 that are relevant to theoretical and computational chemistry corroborate the literature conclusion that there was a 20th century Quantum Chemistry Revolution. A similar analysis is made for the Instrumental Revolution. These analyses are atypical for assessments in the history of science in that rely on Nobel Prize data. It is the congregation of Nobel Prizes that is a telling pointer to a revolution in science, not the examination of any one Nobel Prize.


Corresponding author: Jeffrey I. Seeman, Department of Chemistry, University of Richmond, Richmond, VA, 23173, USA, e-mail:
Dedicated to the historian of science Peter J. T. Morris in honor of his 69th birthday. Article note: A collection of invited papers to celebrate the UN’s proclamation of 2025 as the International Year of Quantum Science and Technology.

Acknowledgments

I thank Russell J. Boyd, A. Ganesan, and Manuel Yáñez for their most collegial invitation to participate in this special issue of Pure and Applied Chemistry. I thank Celia Arnaud, Melinda W. Davis, Ganesan, Roald Hoffmann, and Steven M. Weinreb for helpful suggestions.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Not applicable.

  4. Use of Large Language Models, AI and Machine Learning Tools: Not applicable.

  5. Conflict of interest: None.

  6. Research funding: None.

  7. Data availability: None.

References

1. Seeman, J. I. Revolutions in Chemistry: Assessment of Six 20th Century Candidates (the Instrumental Revolution; Hückel Molecular Orbital Theory; Hückel’s 4n+2 Rule; the Woodward-Hoffmann Rules; Quantum Chemistry; and Retrosynthetic Analysis). J. Am. Chem. Soc. Au 2023, 3, 2378–2401.10.1021/jacsau.3c00278Suche in Google Scholar PubMed PubMed Central

2. Seeman, J. I. Revolutions in Science. Revolutions in Chemistry. Found. Chem. 2023, 25, 321–335; https://doi.org/10.1007/s10698-023-09467-w.Suche in Google Scholar

3. Kuhn, T. S. The Structure of Scientific Revolutions; University of Chicago Press: Chicago, IL, 1962.Suche in Google Scholar

4. Cohen, I. B. The Eighteenth-Century Origins of the Concept of Scientific Revolution. J. Hist. Ideas 1976, 37, 257–288; https://doi.org/10.2307/2708824.Suche in Google Scholar

5. Corrick, J. A. Recent Revolutions in Chemistry; Franklin Watts: New York, NY, 1986.Suche in Google Scholar

6. Cohen, I. B. Revolution in Science; Harvard University Press: Cambridge, MA, 1987.10.1119/1.15274Suche in Google Scholar

7. Cohen, H. F. The Scientific Revolution. A Historiographical Inquiry; Chicago University Press: Chicago, IL, 1994.Suche in Google Scholar

8. Kuhn, T. S. The Structure of Scientific Revolutions, 3rd ed.; University of Chicago Press: Chicago, IL, 1996.Suche in Google Scholar

9. From Classical to Modern Chemistry. The Instrumental Revolution; Morris, P. J. T., Ed.; Royal Society of Chemistry, the Science Museum, London, and the Chemical Heritage Foundation: Cambridge, England, 2002.Suche in Google Scholar

10. Kuhn, T. S. The Structure of Scientific Revolutions, 2nd ed.; University of Chicago Press: Chicago, IL, 1970.Suche in Google Scholar

11. Cahan, D. The Institutional Revolution in German Physics, 1865-1914. Hist. Stud. Phys. Sci. 1985, 15, 1–65. https://doi.org/10.2307/27757549.Suche in Google Scholar

12. Perrin, C. E. Revolution or Reform: the Chemical Revolution and Eighteenth Century Concepts of Scientific Change. Hist. Sci. 1987, 25, 395–423. https://doi.org/10.1177/007327538702500403Suche in Google Scholar

13. Holmes, F. L. The Boundaries of Lavoisier’s Chemical Revolution. Revue d’histoire des sciences 1995, 48, 9–48; https://doi.org/10.3406/rhs.1995.1220.Suche in Google Scholar

14. Holmes, F. L. The “Revolution in Chemistry and Physics”: Overthrow of a Reigning Paradigm or Competition Between Contemporary Research Programs? Isis 2000, 91, 735–753; https://doi.org/10.1086/384947.Suche in Google Scholar PubMed

15. Seeman, J. I.; Restrepo, G. The Mutation of the “Nobel Prize in Chemistry” into the “Nobel Prize in Chemistry or Life Sciences”: Several Decades of Transparent and Opaque Evidence of Change within the Nobel Prize Program. Angew. Chem. Int. Ed. 2020, 59, 2942–2961; https://doi.org/10.1002/anie.201906266.Suche in Google Scholar PubMed

16. Seeman, J. I.; Restrepo, G. The Uncertain Role of Nominations for the Nobel Prize in Chemistry. Chem. Eur. J. 2023, 1–15, e202203985; https://doi.org/10.1002/chem.202203985.Suche in Google Scholar PubMed

17. Seeman, J. I.; Restrepo, G. On the Non-Existent Nobel Prizes for Two Pioneers of Modern Physical Organic Chemistry: Sir Christopher K. Ingold and Saul Winstein. J. Phys. Org. Chem. 2023, 1–19, e4551.10.1002/poc.4551Suche in Google Scholar

18. Seeman, J. I.; Amaya, J.; Restrepo, G. How the Nobel Committee for Chemistry has Shaped the Nobel Prize: Historical Trends Based on the Nobel Prize Nomination Archive. ACS Omega 2025, 10, 20078–20094. https://doi.org/10.1021/acsomega.4c08461.Suche in Google Scholar PubMed PubMed Central

19. Friedman, R. M. The Politics of Excellence: Behind the Nobel Prize in Science; W. H. Freeman/Times Books: New York, NY, 2001.Suche in Google Scholar

20. Coffey, P. Cathedrals of Science: The Personalities and Rivalries that Made Modern Chemistry; Oxford University Press: Oxford, England, 2008.10.1093/oso/9780195321340.001.0001Suche in Google Scholar

21. Seeman, J. I.; House, M. C. Authorship Issues and Conflict in the U.S. Academic Chemical Community. Account. Res. 2015, 22, 346–383; https://doi.org/10.1080/08989621.2015.1047707.Suche in Google Scholar PubMed PubMed Central

22. Withers, N.; Robinson, P.; Valser, B.; Walter, P. The Data Behind the Nobel Prizes. Chem. World 2019. https://www.chemistryworld.com/nobel-prize/the-data-behind-the-nobel-prizes/4010453 (accessed June 15, 2023).Suche in Google Scholar

23. Seeman, J. I.; House, M. C. “For Its Size, the Most Complex Natural Product Known.” Who Deserves Credit for Determining the Structure of Strychnine? ACS Cent. Sci. 2022, 8, 1–10. https://doi.org/10.1021/acscentsci.1c01348.Suche in Google Scholar PubMed PubMed Central

24. Burke, M. Nobel Nominations Analysis Reveals Factors Behind Who Won in the past. Chem. World 2023. https://www.chemistryworld.com/news/nobel-nominations-analysis-reveals-factors-behind-who-won-in-the-past/4017517.article#wrapper_sleeve (accessed June 4, 2023).Suche in Google Scholar

25. Boyd, R. J. The Nobel History of Computational Chemistry. A Personal Perspective. J. Comput. Chem. 2024, 45, 1921–1935; https://doi.org/10.1002/jcc.27383. https://onlinelibrary.wiley.com/doi/abs/10.1002/jcc.27383.Suche in Google Scholar PubMed

26. Ganesan, A. email to Seeman, J. I.: Norwich, England, 2025.Suche in Google Scholar

27. Hahn, O. Nobel Lecture: From the Natural Transmutations of Uranium to its Artificial Fission; Nobel Foundation: Stockholm, Sweden, 1946. https://www.nobelprize.org/uploads/2018/06/hahn-lecture.pdf and https://www.nobelprize.org/prizes/chemistry/1944/hahn/lecture/ (accessed November 10, 2023).Suche in Google Scholar

28. Garfield, E. The ‘Obliteration Phenomenon’ in Science – and the Advantage of Being Obliterated. Curr. Contents 1975 (December 22), 5–7.Suche in Google Scholar

29. Merton, R. K. The Matthew Effect in Science, II. Cumulative Advantage and the Symbolism of Intellectual Property. Isis 1988, 79, 606–623; https://doi.org/10.1086/354848.Suche in Google Scholar

30. Merton, R. K. The Thomas Theorem and the Matthew Effect. Soc. Forces 1995, 74, 379–424; https://doi.org/10.2307/2580486.Suche in Google Scholar

31. McCain, K. W. Eponymy and Obliteration by Incorporation: the Case of the “Nash Equilibrium”. J. Am. Soc. Inform. Scie. Tech. 2011, 62, 1412–1424; https://doi.org/10.1002/asi.21536.Suche in Google Scholar

32. Anonymous. Obliteration by Incorporation; Wikipedia Foundation, 2025. https://en.wikipedia.org/wiki/Obliteration_by_incorporation (accessed June 3, 2025).Suche in Google Scholar

33. Seeman, J. I.; Tantillo, D. J. Understanding Chemistry: from ‘Heuristic (Soft) Explanations and Reasoning by Analogy’ to ‘Quantum Chemistry’. Chem. Sci. 2022, 13, 11461–11486. https://doi.org/10.1039/D2SC02535C.Suche in Google Scholar

34. Debye, P. Methods to Determine the Electrical and Geometrical Structure of Molecules: Stockholm, Sweden, 1936. https://www.nobelprize.org/prizes/chemistry/1936/debye/lecture/ (accessed June 3, 2025).Suche in Google Scholar

35. Betzig, E. Single Molecules, Cells, and Super-Resolution Optics; Nobel Foundation: Ashburn, VA and Stockholm, Sweden, 2014. https://www.nobelprize.org/uploads/2018/06/betzig-lecture.pdf (accessed June 3, 2025).Suche in Google Scholar

36. Moerner, W. F. Single-Molecule Spectroscopy, Imaging, and Photocontrol: Foundations for Super-Resolution Microscopy; Nobel Foundation: Stanford, CA, 2014. https://www.nobelprize.org/uploads/2018/06/moerner-lecture.pdf (accessed June 2, 2025).Suche in Google Scholar

37. Reinhardt, C. Iupac Engagement in the Instrumental Revolution. Chem. Int. 2019, 41, 35–38. https://doi.org/10.1515/ci-2019-0312.Suche in Google Scholar

38. Chamizo, J. A. The Role of Instruments in Three Chemical Revolutions. Sci. Educ. 2014, 23, 298–304; https://doi.org/10.1007/s11191-014-9678-x.Suche in Google Scholar

39. Chamizo, J. A. About Continuity and Rupture in the History of Chemistry: the Fourth Chemical Revolution (1945–1966). Found. Chem. 2019, 21, 11–29; https://doi.org/10.1007/s10698-018-9308-9.Suche in Google Scholar

40. Reinhardt, C. The Chemist or an Instrument: Mass Spectrometry and Structural Organic Chemistry. In From Classical to Modern Chemistry. The Instrumental Revolution; Morris, P. J. T., Ed.; Royal Society of Chemistry, the Science Museum, London, and the Chemical Heritage Foundation: Cambridge, England, 2002; pp. 229–247.Suche in Google Scholar

41. Morris, P. J. T.; Travis, A. S. The Role of Physical Instrumentation in Structural Organic Chemistry in the Twentieth Century. In From Classical to Modern Chemistry. The Instrumental Revolution; Morris, P. J. T., Ed.; Royal Society of Chemistry, the Science Museum, London, and the Chemical Heritage Foundation: Cambridge, England, 2002; pp. 57–84.Suche in Google Scholar

42. Humphreys, P. Computational Science and its Effects. In Philosophical Papers; Humphreys, P., Ed.; Oxford University Press, 2019; pp. 21–57.10.1093/oso/9780199334872.003.0003Suche in Google Scholar

43. Putnam, H. Mathematics, Matter and Method; Cambridge University Press: Cambridge, England, 1975.Suche in Google Scholar

44. Nobel, A. Full Text of Alfred Nobel’s Will, Paris, France and Stockholm, Sweden, 1895. https://www.nobelprize.org/alfred-nobel/full-text-of-alfred-nobels-will-2/ (accessed June 2, 2025).Suche in Google Scholar

45. Anonymous Nobel Prize in Chemistry 2013, “Taking the Experiment to Cyberspace”; Royal Swedish Academy of Sciences: Stockholm, Sweden, 2013. https://www.nobelprize.org/uploads/2018/06/popular-chemistryprize2013.pdf (accessed July 7, 2025).Suche in Google Scholar

46. Anonymous Oxford English Dictionary: “Instrumentation”; Oxford University Press: Oxford, England, 2025. https://www.oed.com/dictionary/instrumentation_n?tab=meaning_and_use#391319 (accessed July 10, 2025).Suche in Google Scholar

47. Scerri, E. Philosophy of Chemistry. In Handbook for the History of Philosophy of Science; Padovani, F., Ed.; Routledge: London, 2024.Suche in Google Scholar

48. Laplane, L.; Mantovani, P.; Adolphs, R.; Chang, H.; Mantovani, A.; McFall-Ngai, M.; Rovelli, C.; Sober, E.; Pradeu, T. Opinion: Why Science Needs Philosophy. Proc. Natl. Acad. Sci. 2019, 116, 3948–3952; https://doi.org/10.1073/pnas.1900357116.Suche in Google Scholar

49. Martin, A. J. P. The Development of Partition Chromatography: Stockholm, Sweden, 1952. https://www.nobelprize.org/uploads/2018/06/martin-lecture.pdf (accessed June 3, 2025).Suche in Google Scholar

50. Strom, E. T.; Mainz, V. V., Eds.; American Chemical Society: Washington, D.C., Vol. 1262, 2017. 0-8412-3251-2. The Posthumous Nobel Prize in Chemistry. Volume 1. Correcting the Errors and Oversights of the Nobel Prize Committee.10.1021/bk-2017-1262Suche in Google Scholar

51. Strom, E. T.; Mainz, V. V., Eds.; American Chemical Society, Vol. 2, 2018. 0-8412-3251-2. The Posthumous Nobel Prize in Chemistry. Correcting the Errors and Oversights of the Nobel Prize Committee.Suche in Google Scholar

52. Roberts, J. D. The Right Place at the Right Time. In Profiles, Pathways and Dreams; Seeman, J. I., Ed.; American Chemical Society: Washington, D.C., 1990.Suche in Google Scholar

53. Roberts, J. D. The Beginnings of Physical Organic Chemistry in the United States. Bull. Hist. Chem. 1996, 19, 48–56; https://doi.org/10.70359/bhc1996n19p048.Suche in Google Scholar

54. Roberts, J. D. A Perspective Distilled from Seventy Years of Research. J. Org. Chem. 2009, 74, 4897–4917; https://doi.org/10.1021/jo900641t.Suche in Google Scholar PubMed

55. Seeman, J. I. John D. Roberts, a Tenacious yet Benevolent Role Model and an Uncelebrated Historian of Chemistry. J. Phys. Org. Chem. 2018, 31, 1–22; e3825. https://doi.org/10.1002/poc.3825.Suche in Google Scholar

56. Djerassi, C. Steroids Made it Possible, In Profiles, Pathways and Dreams; Seeman, J. I., Ed.; American Chemical Society: Washington, D.C., 1990.Suche in Google Scholar

57. Djerassi, C. The Pill, Pygmy Chimps, and Degas’ Horse; Basic Books: New York, 1992.Suche in Google Scholar

58. Djerassi, C. Steroid Research at Syntex: “The Pill” and Cortisone. Steroids 1992, 57, 631–641; https://doi.org/10.1016/0039-128x(92)90016-3.Suche in Google Scholar PubMed

59. Djerassi, C. Natural Products Structure Elucidation: 1950 → 2000. In Pioneering Ideas for the Physical and Chemical Sciences. Josep Loschmidt’s Contributions and Modern Developments in Structural Organic Chemistry, Atomistics, and Statistical Mechanics; Fleischhacker, W.; Schönfeld, T., Eds.; Plenum Press: New York and London, 1997; pp. 15–24.Suche in Google Scholar

60. Nakanishi, K. A Wandering Natural Products Chemist, In Profiles, Pathways and Dreams; J. I. Seeman, ed., Ed.; American Chemical Society: Washington, D.C., 1995.Suche in Google Scholar

61. Nakanishi, K. A Brief History of Natural Products Chemistry. In Comprehensive Natural Products Chemistry; Barton, D. H. R.; Nakanishi, K.; Mett-Cohn, O., Eds.; Elsevier Science: Kidlington, England, Vols 1–8, 1999; pp. xxi–xxxviii.10.1016/B978-0-08-091283-7.09008-1Suche in Google Scholar

62. Circular Dichroism. Principles and Applications; Berova, N.; Nakanishi, K.; Woody, R. W., Eds.; John Wiley & Sons: New York, 2000.Suche in Google Scholar

63. Blout, E. Robert Burns Woodward, 1917–1979, a Biographical Memoir. Biogr. Mem. Natl. Acad. Sci. U.S.A. 2001, 80, 2–23.Suche in Google Scholar

64. Todd, A.; Cornforth, J. W. Robert Burns Woodward: 10 April 1917 – 8 July 1979. Biogr. Mems Fell. R. Soc. Lond. 1981, 27, 629–695.10.1098/rsbm.1981.0025Suche in Google Scholar

65. Seeman, J. I. R. B. Woodward, a Great Physical Organic Chemist. J. Phys. Org. Chem. 2014, 27, 708–721; https://doi.org/10.1002/poc.3328.Suche in Google Scholar

66. Gallotti, R.; De Domenico, M. Effects of Homophily and Academic Reputation in the Nomination and Selection of Nobel Laureates. Sci. Rep. 2019, 9, 17304. https://doi.org/10.1038/s41598-019-53657-6.Suche in Google Scholar PubMed PubMed Central

67. Kang, G.; Kang, Y.; Kang, F.-A. The Extended Woodward UV Rules Formula for all Possible Structures. J. Phy. Org. Chem. 2021, e4186.10.1002/poc.4186Suche in Google Scholar

68. Ganesan, A. The Organic Chemist and the Quantum Through the Prism of R. B. Woodward. Pure Appl. Chem. 2025. accepted for publication.Suche in Google Scholar

69. The Posthumous Nobel Prize in Chemistry. Volume 2. Ladies in Waiting for the Nobel Prize; Mainz, V. V.; Strom, E. T., Eds.; American Chemical Society: Washington, D.C., Vol. 1311, 2018. 0-8412-3391-8 https://doi.org/10.1021/bk-2018-1311.ix002.Suche in Google Scholar

70. Friedman, R. M. Nobel Physics Prize in Perspective. Nature 1981, 292, 793–798; https://doi.org/10.1038/292793a0.Suche in Google Scholar

71. Friedman, R. M. The 100th Anniversary of Einstein’s Nobel Prize: Facts and Fiction. Ann. Phys. (Berlin) 2022, 534, 1–9; https://doi.org/10.1002/andp.202200305.Suche in Google Scholar

72. Källstrand, G. Science by Nobel Committee: Decision Making and Norms of Scientific Practice in the Early Physics and Chemistry Prizes. Brit. J. Hist. Sci. 2022, 1–19; https://doi.org/10.1017/S0007087422000176.Suche in Google Scholar PubMed

73. Mulliken, R. S. The Assignment of Quantum Numbers for Electrons in Molecules. I. Phys. Rev. 1928, 32, 186–222; https://doi.org/10.1103/physrev.32.186.Suche in Google Scholar

74. Rabkin, Y. M. Technological Innovation in Science. the Adoption of Infrared Spectroscopy by Chemists. Isis 1987, 78, 31–54; https://doi.org/10.1086/354329.Suche in Google Scholar

75. Fabelinskii, I. L. Priority and the Raman Effect. Nature 1990, 343, 686. https://doi.org/10.1038/343686a0.Suche in Google Scholar

76. Wang, L. Landmark Achievements. Award Program Honors Institutions Where Breakthrough Discoveries Occurred. Chem. Eng. News 2007, 85 (April 30), 35.Suche in Google Scholar

77. Seeman, J. I.; Mainz, V. Citation for Chemical Breakthrough Awards; Division of History of Chemistry of the American Chemical Society: Washington, DC, 2025. https://acshist.scs.illinois.edu/awards/citations_chem-breakthroughs.php (accessed August 3, 2025).Suche in Google Scholar

Received: 2025-06-11
Accepted: 2025-07-13
Published Online: 2025-08-06

© 2025 IUPAC & De Gruyter

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