Microparticles zerumbone from Zingiber zerumbet rhizome in chitosan modified oleic acid
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Natalia Marbun
Abstract
Zerumbone is a marker compound of Zingiber zerumbet that has antioxidant and anticancer properties. It exhibits low solubility in water, necessitating methods to enhance it has solubility, such as the creation of microparticles with chitosan in oleic acid. Therefore, this research aimed to isolate zerumbone from Z. zerumbet rhizome and determine the formation of its microparticles in chitosan in oleic acid. Zerumbone isolated by recrystallization the Z. zerumbet essential oil. Six different formulations of microparticles with chitosan (2.5–3.0 %), TPP as cross-linker, oleic acid as surfactant, and zerumbone. The formation of microparticles was analyzed using FTIR. The results showed a zerumbone yield of 0.11 % decibels. The particle size of the best microparticle was 5.516 μm, absorptive efficiency is 47 %, and amide linkages between the chitosan and oleic acid were confirmed based on FTIR. The microparticles have LC50 value lower than native zerumbone. The zerumbone microparticles in chitosan-modified oleic acid have great potential for zerumbone delivery.
Acknowledgments
Department of Chemistry, IPB University Tropical Biopharmaca Research Center, IPB University.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: Natalia has conceptualized and designed the research, performed the majority of the data analysis, conducted experiments, collected data, interpretation of the results, and wrote the initial draft of the manuscript. Fardhan, Kirana, Gita, and Muttaqin have conceptualized and designed the research, conducted experiments, collected data, and contributed to the interpretation of the results Irmanida Batubara has supervised the overall research, conceptualized and design the research, provided expert guidance throughout the project, and contributed to interpreting the results and final manuscript revision.
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Use of Large Language Models, AI and Machine Learning Tools: Not applicable.
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Conflict of interests: Not applicable.
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Research funding: Not applicable.
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Data availability: Not applicable.
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Articles in the same Issue
- Frontmatter
- In this issue
- Preface
- Preface: 9th International Conference for Young Chemists (ICYC) 2024
- Research Articles
- Doping TiO2 with Cu from electroplating wastewater for remarkable improvement of its activity under visible light for E. coli bacterial disinfection in water
- Investigating the potential of prenylated and geranylated acylphloroglucinol-based xanthenones as potent soybean 15-lipoxygenase inhibitors: a combined in vitro and in silico approach
- Intelligent food packaging from Ganyong starch (Canna Edulis Kerr.) modified with nanocellulose from corn husk (Zea mays) and curcumin as bioindicator
- Evaluation of 2-(1H-1,2,3-triazol-1-yl) acetic acid derivatives as potential human hypoxia-inducible factor (HIF) prolyl hydroxylase domain-2 (PHD2) inhibitors
- Microparticles zerumbone from Zingiber zerumbet rhizome in chitosan modified oleic acid
- Enhanced visible photocatalytic degradation of diclofenac by ultrasound-assisted prepared C and N co-doping TiO2
- Enhanced stability and permeability of graphene oxide nanocomposite membranes via glycine and diglycine cross-linking
- Furanyl-Chalcones as antimalarial agent: synthesis, in vitro study, DFT, and docking analysis of PfDHFR inhibition
Articles in the same Issue
- Frontmatter
- In this issue
- Preface
- Preface: 9th International Conference for Young Chemists (ICYC) 2024
- Research Articles
- Doping TiO2 with Cu from electroplating wastewater for remarkable improvement of its activity under visible light for E. coli bacterial disinfection in water
- Investigating the potential of prenylated and geranylated acylphloroglucinol-based xanthenones as potent soybean 15-lipoxygenase inhibitors: a combined in vitro and in silico approach
- Intelligent food packaging from Ganyong starch (Canna Edulis Kerr.) modified with nanocellulose from corn husk (Zea mays) and curcumin as bioindicator
- Evaluation of 2-(1H-1,2,3-triazol-1-yl) acetic acid derivatives as potential human hypoxia-inducible factor (HIF) prolyl hydroxylase domain-2 (PHD2) inhibitors
- Microparticles zerumbone from Zingiber zerumbet rhizome in chitosan modified oleic acid
- Enhanced visible photocatalytic degradation of diclofenac by ultrasound-assisted prepared C and N co-doping TiO2
- Enhanced stability and permeability of graphene oxide nanocomposite membranes via glycine and diglycine cross-linking
- Furanyl-Chalcones as antimalarial agent: synthesis, in vitro study, DFT, and docking analysis of PfDHFR inhibition
