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Peptides for therapeutic applications – challenges and chances

  • Chiara Ruggirello , Karin Mörl and Annette G. Beck-Sickinger EMAIL logo
Published/Copyright: March 1, 2024
Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 96 Issue 1

Abstract

Peptides have beneficial properties for therapeutic applications due to their excellent target specificity, high affinity and activity, low toxicity and predictable metabolism. Thus, they became an important tool for research and medical purpose. However, peptides are fragile molecules, therefore, in order to be used as therapeutic agents they need to be stabilised by non-peptidic modifications. Required improvements of these peptide properties include longer half-life, higher bioavailability, increased potency and efficiency. Strategies to achieve these goals have been identified in the last years, with synthetic strategies to obtain sufficient amounts becoming increasingly important. In this review, peptides are discussed with respect to their therapeutic applications. Examples from glucagon-like peptide 1 receptor agonists are shown. Peptides are compared to small molecules and antibodies with respect to advantages and disadvantages in therapeutic applications.

Keywords: Cellular uptake; distinguished women in chemistry and chemical engineering; G protein-coupled receptors; 2023 IUPAC distinguished women in chemistry and chemical engineering; peptide conjugates; peptide diagnostics; peptide therapeutics; stability; women in science
Corresponding author: Annette G. Beck-Sickinger, Faculty of Life Sciences, Institute of Biochemistry, 9180 Leipzig University , Brüderstr. 34, D04103 Leipzig, Germany, e-mail:
Article note: A special collection of invited papers by recipients of the 2023 IUPAC Distinguished Women in Chemistry and Chemical Engineering Awards.

Funding source: Deutscher Akademischer Austauschdienst

Award Identifier / Grant number: Chiara Ruggirello

Acknowledgment

The authors would like to thank the DAAD for its financial support, thanks to which it has been possible to carry out this work.

  1. Research funding: This work was funded by Deutscher Akademischer Austauschdienst (Chiara Ruggirello).

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Published Online: 2024-03-01
Published in Print: 2024-01-29

© 2024 IUPAC & De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. IUPAC Distinguished Women in Chemistry and Chemical Engineering Awards 2023
  4. Special topic papers
  5. Catalytic oxidative carbon–carbon bond-formations of benzene-1,2-diols
  6. Supramolecular assemblies with macrocyclic hosts: applications in antibacterial activity
  7. Women in chemistry: remarkable progress, but are we there yet?
  8. Automating the production of [Fe18FF2(BnMe2-tacn)] and investigating radiostabilisers for use with high-activity [18F]F−
  9. Bridging two worlds: (DABCO-H)CuKI3 a hybrid copper iodide phosphor with a perovskite structure
  10. Empowering women in science through role models, mentors, and support groups: a personal perspective
  11. Peptides for therapeutic applications – challenges and chances
  12. Mechanisms of chemical vapor generation by aqueous boranes for trace element analysis: a rather long and unfinished story
  13. IUPAC Technical Report
  14. A brief guide to measurement uncertainty (IUPAC Technical Report)
  15. IUPAC Recommendations
  16. Definition of the pnictogen bond (IUPAC Recommendations 2023)
https://doi.org/10.1515/pac-2024-0104
Keywords for this article
Cellular uptake; distinguished women in chemistry and chemical engineering; G protein-coupled receptors; 2023 IUPAC distinguished women in chemistry and chemical engineering; peptide conjugates; peptide diagnostics; peptide therapeutics; stability; women in science

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. IUPAC Distinguished Women in Chemistry and Chemical Engineering Awards 2023
  4. Special topic papers
  5. Catalytic oxidative carbon–carbon bond-formations of benzene-1,2-diols
  6. Supramolecular assemblies with macrocyclic hosts: applications in antibacterial activity
  7. Women in chemistry: remarkable progress, but are we there yet?
  8. Automating the production of [Fe18FF2(BnMe2-tacn)] and investigating radiostabilisers for use with high-activity [18F]F−
  9. Bridging two worlds: (DABCO-H)CuKI3 a hybrid copper iodide phosphor with a perovskite structure
  10. Empowering women in science through role models, mentors, and support groups: a personal perspective
  11. Peptides for therapeutic applications – challenges and chances
  12. Mechanisms of chemical vapor generation by aqueous boranes for trace element analysis: a rather long and unfinished story
  13. IUPAC Technical Report
  14. A brief guide to measurement uncertainty (IUPAC Technical Report)
  15. IUPAC Recommendations
  16. Definition of the pnictogen bond (IUPAC Recommendations 2023)
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