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3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury

  • Akingbolabo Daniel Ogunlakin EMAIL logo , Juliana Bunmi Adetunji , Matthew Iyobhebhe , Toluwanimi Ayonitemi Ajiboye , Gideon Ampoma Gyebi , Peluola Olujide Ayeni , Damilare Iyinkristi Ayokunle , Mubo Adeola Sonibare , Joel Ojogbane Onoja , Enitan O. Adesanya EMAIL logo , Omolola Adenike Ajayi-Odoko , Oluwafemi Adeleke Ojo and Sophie Adedamola Adeyeye
Published/Copyright: March 25, 2024
Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 96 Issue 5

Abstract

Various derivatives of cinnamic acid have been reported to possess significant activities such as antioxidant and hepatoprotective, and neuroprotective activities. Interestingly, testicular toxicity has been linked to several causes, with oxidative damage being one of the pathophysiological mechanisms. 3-(4-methoxyphenyl) acrylic acid (1), a derivative of cinnamic acid, was synthesized and then investigated for its effects on iron-induced testicular injury and oxidative stress via ex vivo and in silico studies, respectively. Evaluations were done on KAD-1’s FRAP, DPPH free radical scavenging activity, and iron chelating potential. Through the ex vivo incubation of tissue supernatant and 0.1 mM FeSO4 for 30 min at 37 °C with different concentration of 1, oxidative testicular damage treatments were induced. The scavenging property of 1 increases significantly (p < 0.05) as the concentration increases when compared with the standard quercetin. The MDA, CAT, ATPase, and ENTPDase activities were reduced when testicular damage was induced (p < 0.05). The group treated with 30 mg/mL had the highest level of MDA. A significant rise in GSH level and activity of SOD were observed. The result obtained indicated that 1 has the potential to prevent oxidative testicular toxicity, as evidenced by its capacity to control nucleotide hydrolysis and reduce oxidative stress. Overall, the results of this experimental study point to some possible uses of 3-(4-methoxyphenyl) acrylic acid (1) in the prevention of oxidative testicular dysfunction. Therefore, 3-(4-methoxyphenyl) acrylic acid (1) would be a good product in developing a medication to alleviate male infertility.

Keywords: 3-(4-methoxyphenyl) acrylic acid (1); ATPase; ENTPDase; iron-induced testicular injury; VCCA-2023
Corresponding authors: Akingbolabo Daniel Ogunlakin, Bowen University SDG 03 (Good Health and Wellbeing Research Cluster), Iwo, Nigeria; and Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Department of Biochemistry, Bowen University, Iwo, 232101, Nigeria, Phone: +2347037883049, e-mail: ; and Enitan O. Adesanya, Department of Biochemistry, Olabisi Onabanjo University, Ago-Iwoye, Nigeria, Phone: +2348055123608, e-mail:
Article note: A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications 2023 (VCCA-2023).

  1. Research funding: This research received no external funding.

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Published Online: 2024-03-25
Published in Print: 2024-05-27

© 2024 IUPAC & De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Special topic papers
  4. Ozone-initiated degradation of 1,2-dichlorobenzene over ceria-supported manganese, nickel, vanadium and iron catalysts
  5. The effect of chemical modification using citraconic anhydride on the stability of α-amylase from Aspergillus fumigatus
  6. Decarbonizing our environment via the promotion of biomass methanation in developing nations: a waste management tool
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  9. Surface tension measurement of FAP-based ionic liquid pendant drops in a high vacuum/gas cell
  10. Investigating the bioactive compounds from Capsicum annum as a probable alternative therapy for prostate cancer treatment: a structure-based drug design approach
  11. Crucial role of the internalisation of the distinction between dependent and independent variables for clearer chemistry understanding
  12. 3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury
  13. Computational study on reactivity, aromaticity, and absorption spectra of chrysene: effect of BN doping and substituents
  14. Health benefit of lipid composition of orange (Citrus sinensis) fruit pulp at different maturation stages
https://doi.org/10.1515/pac-2023-1201
Keywords for this article
3-(4-methoxyphenyl) acrylic acid (1); ATPase; ENTPDase; iron-induced testicular injury; VCCA-2023

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Special topic papers
  4. Ozone-initiated degradation of 1,2-dichlorobenzene over ceria-supported manganese, nickel, vanadium and iron catalysts
  5. The effect of chemical modification using citraconic anhydride on the stability of α-amylase from Aspergillus fumigatus
  6. Decarbonizing our environment via the promotion of biomass methanation in developing nations: a waste management tool
  7. Maximising the consistency of the presentation of the molecular level with its quantum mechanical description: challenges and opportunities
  8. The amide group and its preparation methods by acid-amine coupling reactions: an overview
  9. Surface tension measurement of FAP-based ionic liquid pendant drops in a high vacuum/gas cell
  10. Investigating the bioactive compounds from Capsicum annum as a probable alternative therapy for prostate cancer treatment: a structure-based drug design approach
  11. Crucial role of the internalisation of the distinction between dependent and independent variables for clearer chemistry understanding
  12. 3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury
  13. Computational study on reactivity, aromaticity, and absorption spectra of chrysene: effect of BN doping and substituents
  14. Health benefit of lipid composition of orange (Citrus sinensis) fruit pulp at different maturation stages
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