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Antioxidant metal oxide nanozymes: role in cellular redox homeostasis and therapeutics

  • Namrata Singh ORCID logo EMAIL logo
Published/Copyright: November 3, 2020

Abstract

Nanomaterials with enzyme-like activity, generally referred to as ‘nanozymes’, find myriad potential in various biomedical fields. More importantly, the nanoparticles that can functionally mimic the activity of cellular antioxidant enzymes attract tremendous interest owing to their possible therapeutic candidature in oxidative stress-mediated disorders. Oxidative stress culminating due to excess reactive oxygen species (ROS) level and dysregulated cellular antioxidant machinery is implicated in the development and progression of various pathophysiological disorders such as cancer, diabetes, cardiovascular and neurodegenerative diseases. Moreover, the optimum essentiality of ROS due to its pivotal role in cell signaling evokes the requirement of novel artificial antioxidant enzymes that can circumvent the detrimental effects of enhanced ROS levels without perturbing the basal redox status of cells. In recent years, the fast emanating artificial enzymes, i.e. nanozymes with antioxidant enzyme-like activity, has made tremendous progress with their broad applications in therapeutics, diagnostic medicine, bio-sensing, and immunoassay. Among various antioxidant nanoparticles reported till-date, the metal oxide nanozymes have emerged as the most efficient and successful candidates in mimicking the activity of first-line defense antioxidant enzymes, i.e. superoxide dismutase, catalase, and glutathione peroxidase. This review intends to exclusively highlight the development of representative metal oxide-based antioxidant nanozymes capable of maintaining the cellular redox homeostasis and their potential therapeutic significance.


Article note:

A collection of peer-reviewed articles by the winners of the 2020 IUPAC-Solvay International Award for Young Chemists.



Corresponding author: Namrata Singh, Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India, e-mail:

Acknowledgment

I would like to express my sincere gratitude to Prof. G. Mugesh for his guidance and constant support during my graduate studies. I thank Prof. G. Mugesh, Dr. P. Prakash, Dr. Geethika. M and Prof. V. Venkatesh, for their critical inputs and comments in the preparation of this manuscript. N. S. thanks Pure and Applied Chemistry for the invitation to author this review. N.S. is currently a Postdoctoral fellow with Prof. Molly Stevens at Imperial College London.

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Published Online: 2020-11-03
Published in Print: 2021-02-23

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