Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damage
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Thomas Schmitz
,
Ursula Felderhoff-Mueser
Abstract
Perinatal brain damage may result in impaired neurological development in extremely preterm infants. The underlying pathophysiological mechanisms are complex, and biomarkers of prognostic value are not available. The aim of this study was to analyze soluble Fas (sFas) concentrations in the cerebrospinal fluid (CSF) representative for involvement of apoptotic processes in preterm infants developing posthemorrhagic hydrocephalus (PHHC) and to link them to white matter damage (WMD) diagnosed by cranial ultrasound. A total of 29 preterm infants with PHHC were included in the study; 17 of them had signs of cystic WMD (cWMD) on ultrasound examinations. CSF samples were obtained at first ventriculostomy, and results were compared to those of a reference group of 24 preterm and term infants without neurologic diseases. sFas concentrations were elevated in CSF samples of PHHC patients compared to the reference group. In patients with cWMD, sFas concentrations were significantly higher than in patients without cWMD. These results indicate that apoptosis via the Fas pathway is involved in the pathogenesis of cWMD in the context of PHHC, and that sFas in the CSF may serve as a marker of cWMD development.
©2011 by Walter de Gruyter Berlin New York
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- Congress Calendar
Articles in the same Issue
- Publisher's note
- Publisher's Note
- Review articles
- 3D and 4D sonography and magnetic resonance in the assessment of normal and abnormal CNS development: alternative or complementary
- Selective reduction in twins and multiple pregnancies
- Original articles – Obstetrics
- Do uterotrophic drugs increase the risk of fatal hemorrhagic brain stroke?
- Parental factors affecting the weights of the placenta and the offspring
- Trends in maternal mortality due to obstetric hemorrhage in urban and rural China, 1996–2005
- Original articles – Fetus
- Abdominal circumference ratio for the diagnosis of intertwin birth weight discordance
- Predicting survival of periviable fetuses using NICHD fetal heart rate categories
- Prospective risk of stillbirth in monochorionic-diamniotic twin gestations: a population based study
- Original articles – Newborn
- Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants
- Evaluation and clinical application of changes in thyroid hormone and TSH levels in critically ill full-term newborns
- NCI classification of thrombocytopenia in extremely preterm neonates and its association with mortality and morbidity
- Epidemiology of congenital syphilis in a South Bronx population: a follow-up study
- Quantitative ultramicrotest for newborn screening of galactosemia in Cuba
- Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damage
- Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers
- Letter to the Editors
- Perimortem instrumental vaginal delivery
- Human sex ratio at birth and related factors
- Twins are a risk factor for developing severe hypertensive disorders in the puerperium following a normotensive pregnancy
- Congress calendar
- Congress Calendar
