NCI classification of thrombocytopenia in extremely preterm neonates and its association with mortality and morbidity
-
Shantanu Rastogi
,
Inan Olmez
Abstract
Background: Thrombocytopenia (TP) is a common finding among preterm neonates and has been associated with mortality and morbidities. Yet, there is no consistent classification for neonatal TP. TP in adults has recently been graded by the National Cancer Institute (NCI) Common Toxicity Criteria and has been shown to predict clinical outcomes.
Objective: To use the NCI classification for TP in preterm neonates and elucidate its association with clinical outcomes.
Methods: Retrospective chart review was done on neonates born at gestational age (GA) ≤28 weeks and survived for ≥7 days. TP was classified as per NCI guidelines at 7 days and 28 days of age and their association with mortality, major morbidities and hospital length of stay (LOS) were investigated.
Results: A total of 286 patients were included in the study with a mean GA of 26.3±1.5 weeks and birth weight of 899±215 g. NCI TP grades at 7 days were significantly (P<0.001) associated with mortality, LOS, intraventricular hemorrhage and Gram negative infections. In addition to these outcomes, necrotizing enterocolitis, Gram positive and fungal infections were also significantly associated with NCI TP grades at 28 days.
Conclusions: Classification of TP using the NCI criteria in extreme preterm neonates is clinically applicable. This grading system of platelet counts is significantly associated with mortality, morbidity and LOS in preterm neonates.
©2011 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Publisher's note
- Publisher's Note
- Review articles
- 3D and 4D sonography and magnetic resonance in the assessment of normal and abnormal CNS development: alternative or complementary
- Selective reduction in twins and multiple pregnancies
- Original articles – Obstetrics
- Do uterotrophic drugs increase the risk of fatal hemorrhagic brain stroke?
- Parental factors affecting the weights of the placenta and the offspring
- Trends in maternal mortality due to obstetric hemorrhage in urban and rural China, 1996–2005
- Original articles – Fetus
- Abdominal circumference ratio for the diagnosis of intertwin birth weight discordance
- Predicting survival of periviable fetuses using NICHD fetal heart rate categories
- Prospective risk of stillbirth in monochorionic-diamniotic twin gestations: a population based study
- Original articles – Newborn
- Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants
- Evaluation and clinical application of changes in thyroid hormone and TSH levels in critically ill full-term newborns
- NCI classification of thrombocytopenia in extremely preterm neonates and its association with mortality and morbidity
- Epidemiology of congenital syphilis in a South Bronx population: a follow-up study
- Quantitative ultramicrotest for newborn screening of galactosemia in Cuba
- Expression of soluble Fas in the cerebrospinal fluid of preterm infants with posthemorrhagic hydrocephalus and cystic white matter damage
- Early left ventricular diastolic dysfunction in premature infants born to preeclamptic mothers
- Letter to the Editors
- Perimortem instrumental vaginal delivery
- Human sex ratio at birth and related factors
- Twins are a risk factor for developing severe hypertensive disorders in the puerperium following a normotensive pregnancy
- Congress calendar
- Congress Calendar
