Validation of a model to predict hospitalization due to RSV of infants born at 33–35 weeks' gestation
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Abstract
Background: A model to predict hospitalization due to respiratory syncytial virus (RSV) of infants born at 33– 35 weeks' gestation was developed using seven risk factors from the Spanish FLIP study “birth ±10 weeks from the beginning of the RSV season”, “birth weight”, “breast fed ≤2 months”, “number of siblings ≥2 years”, “number of family members with atopy”, “number of family members with wheezing”, and “gender”. The aim of this study was to validate the model using French data.
Methods: The FLIP model [predictive accuracy 71%, receiver operating characteristic (ROC) 0.791] was tested against the French data (77 hospitalized infants with RSV born at 33–35 weeks and 154 age-matched controls) using discriminatory function analysis by applying the FLIP coefficients to the French data and by generating the seven variable model from the French data.
Results: Applying the FLIP coefficients to the French dataset, the model correctly classified 69% of cases (ROC 0.627). The predictive power increased to 73% (ROC 0.654) when “number of siblings ≥2 years” was substituted for “number of children at school”. The number needed to treat (NNT) in order to prevent 70% of hospitalizations was 18. The model derived using French data could correctly classify 62% of cases in the French data (ROC 0.658).
Conclusions: The model was successfully validated and may potentially optimize immunoprophylaxis in French infants born at 33–35 week's gestation.
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Recommendations and guidelines for perinatal practice
- Donor human milk in preterm infant feeding: evidence and recommendations
- Original articles – Obstetrics
- Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003–2008
- Maternal plasma retinol binding protein 4 in acute pyelonephritis during pregnancy
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- Genital group B streptococcus carrier rate and serotype distribution in Korean pregnant women: implications for group B streptococcal disease in Korean neonates
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- Original articles – Fetus
- Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding
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- Original articles – Newborn
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- Outcomes of extremely low birth weight infants with varying doses and intervals of antenatal steroid exposure
- Dependence of neonatal small and large for gestational age rates on maternal height and weight – an analysis of the German Perinatal Survey
- Clinical characteristics of nosocomial infections in neonatal intensive care unit in eastern China
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- Maternal complications of fetoscopic laser photocoagulation (FLP) for treatment of twin-twin transfusion syndrome (TTTS)
- Letter to the Editor
- A newborn with Down syndrome-transient myeloproliferative disorder
- Congress Calender
- Congress Calendar
- WAPM-Newsletter
- WAPM-Newsletter No 1/2010
