Diagnostic value of interleukin-6 and C-reactive protein on early onset bacterial infection in preterm neonates with respiratory distress
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Maria Aparecida C. Rego
Abstract
Aims: To evaluate the C-reactive protein (CRP) and interleukin-6 (IL-6) as diagnostic tools for early onset infection in preterm infants with early respiratory distress (RD).
Methods: CRP and IL-6 were quantified at identification of RD and 24 h after in 186 newborns. Effects of maternal hypertension, mode of delivery, Apgar score, birth weight, gestational age, mechanical ventilation, being small for gestational age (SGA), and the presence of infection were analyzed.
Results: Forty-four infants were classified as infected, 42 as possibly infected, and 100 as uninfected. Serum levels of IL-6 (0 h), CRP (0 h), and CRP (24 h), but not IL-6 (24 h) were significantly higher in infected infants compared to the remaining groups. The best test for identification of infection was the combination of IL-6 (0 h) 36 pg/dL and/or CRP (24 h) 0.6 mg/dL, which yielded 93% sensitivity and 37% specificity. The presence of infection and vaginal delivery independently increased IL-6 (0 h), CRP (0 h) and CRP (24 h) levels. Being SGA also increased the CRP (24 h) levels. IL-6 (24 h) was independently increased by mechanical ventilation.
Conclusions: The combination of IL-6 (0 h) and/or CRP (24 h) is helpful for excluding early onset infection in preterm infants with RD but the poor specificity limits its potential benefit as a diagnostic tool.
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Review article
- Monochorionic twin pregnancy: screening, pathogenesis of complications and management in the era of microinvasive fetal surgery
- Original articles – Obstetrics
- Longitudinal examination of cervical volume and vascularization changes during the antepartum and postpartum period using three-dimensional and power Doppler ultrasound
- Uterine and umbilical artery Doppler velocimetry as a predictor for adverse pregnancy outcomes in pregnant women with anemia
- Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation
- Two-stage transvaginal cervical length screening for preterm birth in twin pregnancies
- The relationship between placental histology and cervical length in twin gestations
- A novel method for evaluating uterine cervical consistency using vaginal ultrasound gray-level histogram
- Microbial invasion of the amniotic cavity in pregnancies with small-for-gestational-age fetuses
- Microbial invasion of the amniotic cavity in preeclampsia as assessed by cultivation and sequence-based methods
- Original articles – Fetus
- Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats
- Calprotectin in human cord blood: relation to perinatal parameters and restricted fetal growth
- Original articles – Newborn
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- Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats
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- Congress Calendar
