Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: A prospective, randomized, controlled study
-
Amir Kugelman
Abstract
Aim: To evaluate the immunologic and infectious consequences of delayed versus immediate cord clamping in premature infants (<35 weeks) during the neonatal period.
Methods: This was a prospective, masked, randomized, controlled, single-center study. Prior to delivery 35 infants were randomly assigned to immediate cord clamping (ICC) at 5–10 s and 30 infants to delayed cord clamping (DCC), at 30–45 s (14 and 15 infants in each group were <1500 g, respectively).
Results: Neonatal characteristics of the ICC and DCC groups were comparable. There was no significant difference between the ICC and DCC groups in the complement or in the immunoglobulin levels. All were within the normal range for age. All infectious parameters (events of sepsis or “rule-out sepsis”, days of antibiotic therapy, and number of antibiotic courses during hospitalization and infections within the first month of life in cases of earlier discharge) were comparable in both groups. Similar results were found in the subgroup of infants <1500 g. Gender analysis showed only modest differences.
Conclusions: Delayed compared to immediate cord clamping did not affect the immunologic or the infectious status of infants born at <35 weeks during the neonatal period.
©2009 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: A prospective, randomized, controlled study
- Opinion paper
- The Groningen Protocol: Is it necessary? Is it scientific? Is it ethical?
- Original articles – Obstetrics
- Maternal visfatin concentration in normal pregnancy
- Visfatin in human pregnancy: maternal gestational diabetes vis-à-vis neonatal birthweight
- Values of amniotic fluid index in cases of preterm premature rupture of membranes
- Access to level III perinatal care for pregnancies of very short duration (<32 weeks)
- Statistical model predicting a short duration to birth in women with preterm labor at 22–35 weeks' gestation: the importance of large vaginal Gram-positive rods
- Pregnant women's perception of cesarean section on demand
- Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR
- The effect of bilateral pelvic neurectomy on cervical ripening in pregnant rats
- Original article – Fetus
- Evaluation of normal neurological development of human fetuses from 21 to 30 weeks' gestation through fetal auditory evoked response
- Do fetal heart rate deceleration patterns during labor differ between various umbilical cord abnormalities?
- Original articles – Newborn
- Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: A prospective, randomized, controlled study
- The source of Helicobacter pylori infection in the neonatal period
- Neonatal phrenic nerve injury due to traumatic delivery
- Developmental alterations of the prefrontal cerebral cortex in sudden unexplained perinatal and infant deaths
- Letter to the editor
- Palivizumab for prophylaxis of RSV infection: five epidemic seasons' experience on adverse effects (2002–2007)
- Prevention of intrauterine growth restriction: Are there no effective methods available?
- Congress Calender
- 10.1515/JPM.2009.073
Articles in the same Issue
- Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: A prospective, randomized, controlled study
- Opinion paper
- The Groningen Protocol: Is it necessary? Is it scientific? Is it ethical?
- Original articles – Obstetrics
- Maternal visfatin concentration in normal pregnancy
- Visfatin in human pregnancy: maternal gestational diabetes vis-à-vis neonatal birthweight
- Values of amniotic fluid index in cases of preterm premature rupture of membranes
- Access to level III perinatal care for pregnancies of very short duration (<32 weeks)
- Statistical model predicting a short duration to birth in women with preterm labor at 22–35 weeks' gestation: the importance of large vaginal Gram-positive rods
- Pregnant women's perception of cesarean section on demand
- Adiponectin induced placental cell apoptosis could be mediated via the ADIPOR1-receptor in pre-eclampsia with IUGR
- The effect of bilateral pelvic neurectomy on cervical ripening in pregnant rats
- Original article – Fetus
- Evaluation of normal neurological development of human fetuses from 21 to 30 weeks' gestation through fetal auditory evoked response
- Do fetal heart rate deceleration patterns during labor differ between various umbilical cord abnormalities?
- Original articles – Newborn
- Immunologic and infectious consequences of immediate versus delayed umbilical cord clamping in premature infants: A prospective, randomized, controlled study
- The source of Helicobacter pylori infection in the neonatal period
- Neonatal phrenic nerve injury due to traumatic delivery
- Developmental alterations of the prefrontal cerebral cortex in sudden unexplained perinatal and infant deaths
- Letter to the editor
- Palivizumab for prophylaxis of RSV infection: five epidemic seasons' experience on adverse effects (2002–2007)
- Prevention of intrauterine growth restriction: Are there no effective methods available?
- Congress Calender
- 10.1515/JPM.2009.073
