Startseite Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
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Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak

  • Sebastian Häusler EMAIL logo , Marco Weigl , Andreas Ambrosch , Rudolf Gruber , Birgit Seelbach-Göbel und Sara Fill Malfertheiner
Veröffentlicht/Copyright: 24. Februar 2021
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 49 Heft 6

Abstract

Objectives

The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance.

Methods

To screen asymptomatic pregnant women during admission to our university maternal hospital we focused on anti-SARS-CoV-2-specific IgG and IgA antibody responses. Hundred and fifty one women admitted to the hospital for childbirth or caesarean delivery were included. In case of suspicious anti-SARS-CoV-2-antibody levels an RT-PCR was performed to confirm an ongoing infection with SARS-CoV-2.

Results

A total of 89% showed negative results for anti-SARS-CoV-2-IgA antibodies, whereas 3% were borderline and 7% positive (both labeled as suspicious). In only one patient with suspicious serology we detected SARS-CoV-2-RNA in the following RT-PCR. 2% presented anti-SARS-CoV-2-IgG antibodies, all being positive for anti-SARS-CoV-2-IgA. The observed positive rate of our study collective of 10.6% seemed much higher than the expected one (1.3%) based on the reports of the Robert Koch Institute and the specifications given by the test’s manufacturer. The expected positive predictive value (PPV) was 4.3–6.7 times higher than the observed one.

Conclusions

To our knowledge this is the first report of anti-SARS-CoV-2-antibody levels in the peripartum period of asymptomatic women. As the positive anti-SARS-CoV-2 serology poorly correlated with the confirmatory RT-PCR and the fact that mainly the detection of the virus by PCR correlates with the patient’s infectiousness we suggest to rather perform a SARS-CoV-2-PCR-based admission screening in perinatal centers to prevent the spread of the disease.

Keywords: IgA; IgG; peripartum period; pregnancy; SARS-CoV-2; screening
Corresponding author: Sebastian Häusler, MD, University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University Medical Center Regensburg, Steinmetzstr., 1-3, 93049 Regensburg, Germany; and Department of Obstetrics and Gynecology, School of Medicine, University of Würzburg, Josef-Schneider-Str. 4, 97080 Würzburg, Germany, E-mail:
Sebastian Häusler and Marco Weigl contributed equally to this work.

Acknowledgments

We are grateful to all obstetrics patient who participated in the study and to all staff members of our hospital supporting this research project. Moreover, we would like to thank Andrea Seitz for the collection and management of data for this study.

  1. Research funding: None declared.

  2. Author contributions: Sebastian Häusler: Conceptualization (lead); Project administration (supporting); Resources (lead); Supervision (lead); Validation (equal); Writing-review original draft (lead); Marco Weigl: Formal analysis (equal); Investigation (equal); Methodology (equal); Writing-original draft (lead); Birgit Seelbach-Göbel: Review original draft (supporting). Rudolf Gruber: Formal analysis (equal); Methodology (equal). Andreas Ambrosch: Investigation (equal); Methodology (equal); Validation (equal). Sara Fill Malfertheiner: Formal analysis (equal); Investigation (equal); Methodology (equal); Writing-original draft (supporting). All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was approved by the Ethics Committee of the University of Würzburg, Germany (file-number: 20200428-01).

  6. Availability of data and materials: The datasets used and/or analyzed for this paper are available from the corresponding author on reasonable request.

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Received: 2021-01-01
Accepted: 2021-02-08
Published Online: 2021-02-24
Published in Print: 2021-07-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Special Section: Coronavirus Disease 2019 (COVID-19) in Obstetrics
  3. Editorial
  4. COVID-19 in pregnancy: where are we now?
  5. Review
  6. Newborns at risk of Covid-19 ― lessons from the last year
  7. Opinion Paper
  8. Ethical challenges in management of critically ill pregnant patients with coronavirus disease 2019 (COVID-19)
  9. Corner of Academy
  10. Antenatal depression and anxiety during the COVID-19 pandemic: a cross-sectional study in pregnant women from routine health care contact in Greece
  11. Original Articles – Obstetrics
  12. Pregnant women’s psychological state and influence factors: anxiety, and depression during COVID-19 outbreak
  13. Anxiety and depression during pregnancy in the era of COVID-19
  14. COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey
  15. Covid-19 and pregnancy: the experience of a tertiary maternity hospital
  16. Infant outcomes and maternal COVID-19 status at delivery
  17. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study
  18. SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up
  19. Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
  20. SARS-CoV-2 in asymptomatic pregnant women in South Brazil: RT-PCR and serological detection
  21. Letter to the Editor
  22. COVID-19 vaccine: the gender disparity
  23. Regular Papers
  24. Original Articles – Obstetrics
  25. Mode of delivery of women with Swyer syndrome in a German case series
  26. Risk factors and outcomes of abnormal bleeding after external cephalic version
  27. Causal analysis of fetal death in high-risk pregnancies
  28. Original Article – Neonates
  29. Prediction of encephalopathy in perinatal asphyxia score: reaching the unreached
  30. Short Communication
  31. Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester
  32. Online Only: Congress Abstracts
  33. World Congress of Perinatal Medicine
https://doi.org/10.1515/jpm-2021-0001
Schlagwörter für diesen Artikel
IgA; IgG; peripartum period; pregnancy; SARS-CoV-2; screening

Artikel in diesem Heft

  1. Frontmatter
  2. Special Section: Coronavirus Disease 2019 (COVID-19) in Obstetrics
  3. Editorial
  4. COVID-19 in pregnancy: where are we now?
  5. Review
  6. Newborns at risk of Covid-19 ― lessons from the last year
  7. Opinion Paper
  8. Ethical challenges in management of critically ill pregnant patients with coronavirus disease 2019 (COVID-19)
  9. Corner of Academy
  10. Antenatal depression and anxiety during the COVID-19 pandemic: a cross-sectional study in pregnant women from routine health care contact in Greece
  11. Original Articles – Obstetrics
  12. Pregnant women’s psychological state and influence factors: anxiety, and depression during COVID-19 outbreak
  13. Anxiety and depression during pregnancy in the era of COVID-19
  14. COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey
  15. Covid-19 and pregnancy: the experience of a tertiary maternity hospital
  16. Infant outcomes and maternal COVID-19 status at delivery
  17. Assessment of fetal Doppler parameters in pregnant women with COVID-19 infection: a prospective case-control study
  18. SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up
  19. Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak
  20. SARS-CoV-2 in asymptomatic pregnant women in South Brazil: RT-PCR and serological detection
  21. Letter to the Editor
  22. COVID-19 vaccine: the gender disparity
  23. Regular Papers
  24. Original Articles – Obstetrics
  25. Mode of delivery of women with Swyer syndrome in a German case series
  26. Risk factors and outcomes of abnormal bleeding after external cephalic version
  27. Causal analysis of fetal death in high-risk pregnancies
  28. Original Article – Neonates
  29. Prediction of encephalopathy in perinatal asphyxia score: reaching the unreached
  30. Short Communication
  31. Deoxyribonuclease activity negative correlates with extracellular DNA in uncomplicated singleton pregnancies in the third trimester
  32. Online Only: Congress Abstracts
  33. World Congress of Perinatal Medicine
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