Effect of Sjögren’s syndrome on maternal and neonatal outcomes of pregnancy
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Brittney Elliott
Abstract
Background
Sjögren’s syndrome (SS) is an autoimmune connective tissue disease affecting the body’s moisture-producing glands. Some studies have linked SS to adverse maternal/neonatal outcomes, but sample sizes have tended to be small, with few outcomes examined. The purpose of this study was to evaluate the effect of SS on pregnancy outcomes for mother and neonate using a large dataset.
Methods
We carried out a retrospective cohort study of women who delivered between 1999 and 2014 using data from the Nationwide Inpatient Sample from the United States. SS categorization is based on ICD-9 coding. Baseline characteristics were compared in both groups and multivariate logistic regression was used to compare maternal and fetal outcomes of pregnancies in women with and without SS.
Results
The prevalence of SS in our population was 1.34 cases/10,000 births, with the rate increasing over the study period. Women with SS tended to be older, Caucasian and to have pre-existing comorbidities. Births to women with SS were at greater risk of pre-eclampsia [odds ratio (OR) 1.63, 95% confidence interval (CI) 1.34–1.99]; premature rupture of membranes (OR 1.28, 95% CI 1.04–1.57); preterm delivery (OR 1.56, 95% CI 1.34–1.81); cesarean delivery (OR 1.29, 95% CI 1.17–1.41); and venous thromboembolic events (OR 3.71, 95% CI 2.57–5.35). Infants of women with SS were more likely to have intrauterine growth restriction (IUGR) (OR 3.00, 95% CI 2.46–3.65); and congenital malformations (OR 3.26, 95% CI 2.30–4.62).
Conclusion
SS is a high-risk pregnancy condition associated with significant comorbidities and adverse maternal and fetal outcomes. Women with SS may benefit from increased surveillance during their pregnancies.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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© 2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Placenta previa and the risk of intrauterine growth restriction (IUGR): a systematic review and meta-analysis
- Research Articles – Obstetrics
- Total gestational weight gain and the risk of preeclampsia by pre-pregnancy body mass index categories: a population-based cohort study from 2013 to 2017
- Comparison of automated vs. manual measurement to estimate fetal weight in isolated polyhydramnios
- Strain and dyssynchrony in fetuses with congenital heart disease compared to normal controls using speckle tracking echocardiography (STE)
- Maternal abdominal subcutaneous fat thickness as a simple predictor for gestational diabetes mellitus
- Pregnancy outcome following bacteriuria in pregnancy and the significance of nitrites in urinalysis – a retrospective cohort study
- Nearly half of all severe fetal anomalies can be detected by first-trimester screening in experts’ hands
- Effect of maternal obesity on pregnancy outcomes in women delivering singleton babies: a historical cohort study
- Comparison of quantitative fluorescent polymerase chain reaction and karyotype analysis for prenatal screening of chromosomal aneuploidies in 270 amniotic fluid samples
- Effect of Sjögren’s syndrome on maternal and neonatal outcomes of pregnancy
- Intrapartum prediction of birth weight with a simplified algorithmic approach derived from maternal characteristics
- Efficacy of copy-number variation sequencing technology in prenatal diagnosis
- Socio-cultural and clinician determinants in the maternal decision-making process in the choice for trial of labor vs. elective repeated cesarean section: a questionnaire comparison between Italian settings
- Research Articles – Newborn
- Tidal volume monitoring during initial resuscitation of extremely prematurely born infants
- The level of extracellular superoxide dismutase in the first week of life in very and extremely low birth weight infants and the risk of developing bronchopulmonary dysplasia
- Effect of gender on growth-restricted fetuses born preterm
- Letters to the Editor
- Dermal bilirubin kinetics during phototherapy in term neonates
- Transcutaneous bilirubin to guide phototherapy: authors’ reply
Artikel in diesem Heft
- Frontmatter
- Review
- Placenta previa and the risk of intrauterine growth restriction (IUGR): a systematic review and meta-analysis
- Research Articles – Obstetrics
- Total gestational weight gain and the risk of preeclampsia by pre-pregnancy body mass index categories: a population-based cohort study from 2013 to 2017
- Comparison of automated vs. manual measurement to estimate fetal weight in isolated polyhydramnios
- Strain and dyssynchrony in fetuses with congenital heart disease compared to normal controls using speckle tracking echocardiography (STE)
- Maternal abdominal subcutaneous fat thickness as a simple predictor for gestational diabetes mellitus
- Pregnancy outcome following bacteriuria in pregnancy and the significance of nitrites in urinalysis – a retrospective cohort study
- Nearly half of all severe fetal anomalies can be detected by first-trimester screening in experts’ hands
- Effect of maternal obesity on pregnancy outcomes in women delivering singleton babies: a historical cohort study
- Comparison of quantitative fluorescent polymerase chain reaction and karyotype analysis for prenatal screening of chromosomal aneuploidies in 270 amniotic fluid samples
- Effect of Sjögren’s syndrome on maternal and neonatal outcomes of pregnancy
- Intrapartum prediction of birth weight with a simplified algorithmic approach derived from maternal characteristics
- Efficacy of copy-number variation sequencing technology in prenatal diagnosis
- Socio-cultural and clinician determinants in the maternal decision-making process in the choice for trial of labor vs. elective repeated cesarean section: a questionnaire comparison between Italian settings
- Research Articles – Newborn
- Tidal volume monitoring during initial resuscitation of extremely prematurely born infants
- The level of extracellular superoxide dismutase in the first week of life in very and extremely low birth weight infants and the risk of developing bronchopulmonary dysplasia
- Effect of gender on growth-restricted fetuses born preterm
- Letters to the Editor
- Dermal bilirubin kinetics during phototherapy in term neonates
- Transcutaneous bilirubin to guide phototherapy: authors’ reply
