Carboxyhemoglobin in umbilical cord blood and maternal smoking
-
Kevin Hengstler
,
Peter van ’t Sant
Abstract
Background
Smoking during pregnancy still exists in daily life but the effect on the newborn in the early stage of life is still unclear. This study investigates the normal reference range of carboxyhemoglobin (HbCO) in umbilical cord blood gas (UBG).
Methods
A single center retrospective cross-sectional cohort study was performed with 1172 cases. We analyzed HbCO values in umbilical cord blood, maternal smoking, birth weight percentiles, duration of amenorrhea and maternal admission duration prior to delivery.
Results
HbCO levels in newborns range from 0 to 7.7% with a mean of 0.6% (standard deviation 0.6). Newborns from women who smoked during pregnancy have a significant higher HbCO value compared to newborns from women who did not smoke. Birth weight is negatively correlated with HbCO (P = 0.001).
Conclusion
Our results show the normal reference range in this study is 0–1.2% for HbCO in the umbilical blood of newborns. Smoking prior to delivery leads to a higher HbCO value in the UBG sample of the newborn, a lower birth weight and may be potential harmful.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Corner of Academy
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- Original Articles – Obstetrics
- Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis
- The predictive value of serum cancer antigen 125 (CA125) levels on pregnancy outcome in threatened miscarriages
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- Association of dietary intake below recommendations and micronutrient deficiencies during pregnancy and low birthweight
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- Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress
- Standard and adjusted criteria for the use of the misoprostol vaginal insert for labor induction: a comparative cohort study
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- Original Articles – Fetus
- Antenatal ultrasound compared to MRI evaluation of fetal myelomeningocele: a prenatal and postnatal evaluation
- The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates
- Carboxyhemoglobin in umbilical cord blood and maternal smoking
- Original Article – Newborn
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Artikel in diesem Heft
- Frontmatter
- Corner of Academy
- Hemodynamic factors associated with fetal cardiac remodeling in late fetal growth restriction: a prospective study
- Original Articles – Obstetrics
- Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis
- The predictive value of serum cancer antigen 125 (CA125) levels on pregnancy outcome in threatened miscarriages
- Pregnancy outcomes after thyroid cancer
- Maternal and perinatal outcomes in external cephalic version: prognostic factors for the success of the technique
- Association of dietary intake below recommendations and micronutrient deficiencies during pregnancy and low birthweight
- The sFlt-1/PlGF ratio values within the <38, 38–85 and >85 brackets as compared to perinatal outcomes
- Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress
- Standard and adjusted criteria for the use of the misoprostol vaginal insert for labor induction: a comparative cohort study
- New reference values for biometrical measurements and sonographic estimated fetal weight in twin gestations and comparison to previous normograms
- Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy
- Original Articles – Fetus
- Antenatal ultrasound compared to MRI evaluation of fetal myelomeningocele: a prenatal and postnatal evaluation
- The value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) parameters in analysis with fetal malnutrition neonates
- Carboxyhemoglobin in umbilical cord blood and maternal smoking
- Original Article – Newborn
- Macronutrient analysis of preterm human milk using mid-infrared spectrophotometry
