Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
-
Engin Korkmazer
,
Rampia Nizam
Abstract
Objective
Morbidly adherent placenta (MAP) is a clinical condition the prevalance of which is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Several studies have shown that intercellular adhesion molecule-1 (ICAM-1) increases the invasion capability of tumor cells and placental cells. In our study, we investigated the expression of ICAM-1 in MAP cases.
Methods
This is a prospective case-control study. Eighty-nine patients who were diagnosed with MAP and 96 patients, without adherent placenta, as a control group were included in the study. ICAM-1 staining was examined by immuno-histochemical staining in placental samples.
Results
Of the 89 patients in the MAP group, 72 (80.8%) showed positive staining, while 26 (27%) did so in the control group. ICAM-1 positive staining in the MAP group was statistically significantly higher (P=0.03).
Conclusion
This is the first study investigating the relationship between MAP and ICAM-1 in the literature. In our study, we showed that ICAM-1 expression increased in the MAP group.
Acknowledgments
This is an original article and has not been published in any journal before. All authors took responsibility for the manuscript and agreed on sending the original article in the present manner. The authors do not have any personal financial disclosure.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
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- Research Articles – Obstetrics
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- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
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Articles in the same Issue
- Frontmatter
- Review
- Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature
- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
- Corner of Academy
- Midwife-assisted planned home birth: an essential component of improving the safety of childbirth in Sub-Saharan Africa
- Research Articles – Obstetrics
- Maternal body height is a stronger predictor of birth weight than ethnicity: analysis of birth weight percentile charts
- Chromosomal microarray findings in pregnancies with an isolated pelvic kidney
- Serum sFlt-1/PlGF ratio has better diagnostic ability in early- compared to late-onset pre-eclampsia
- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
- Research Articles – Fetus
- Untimely diagnosis of fetomaternal hemorrhage: what went wrong?
- Quantification of fetal myocardial function in pregnant women with diabetic diseases and in normal controls using speckle tracking echocardiography (STE)
- Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment
- Research Articles – Newborn
- Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
- Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit: the VIRIoN-C study
- Adverse neonatal outcomes and house prices in London
- A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
- Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
- From single-case analysis of neonatal deaths toward a further reduction of the neonatal mortality rate
- Short Communication
- Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes
