A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
-
Marta Cabrera Lafuente
,
Mͣ Teresa Montes Bueno
Abstract
Background
Mothers of preterm (PT) infants have difficulty providing adequate quantities of human milk (HM) for their babies during their hospital stay. The macronutrient content in HM changes over time, varying across and within individual mothers. The research aim of the strudy was to describe the intake of mothers’ own milk (MOM) and its composition according to gestational (GA) and postnatal age (PNA) in infants born <32 weeks’ GA and to correlate them with neonatal weight, length and morbidities.
Methods
A prospective observational study of 176 premature infants in a unit without a donor milk bank was conducted. Daily milk intake was recorded. HM macronutrients were determined by mid-infrared spectrophotometric analysis at 7, 15 and 30 days after delivery and monthly until hospital discharge.
Results
Intake of MOM increased during the first 2 weeks after birth and decreased steadily thereafter. Protein concentration varied inversely with PNA. Carbohydrate and lipid concentrations increased over the first few days and remained stable thereafter. A fall in weight percentiles from birth to 60 days was found. No correlation was found between total protein and calorie intakes at 3 and 15 days of life and growth velocity (GV) between 15 and 30 days, even when broken down into parenteral nutrition (PN), formula and MOM.
Conclusion
To improve MOM feeding in PT newborns, intensive support strategies at the prenatal stage along entire hospitalization income should be encouraged. New protocols for fortification of HM should be implemented to optimize postnatal weight gain while preserving the health benefits of HM.
Acknowledgments
We thank the mothers and infants who participated in this study.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Review
- Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature
- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
- Corner of Academy
- Midwife-assisted planned home birth: an essential component of improving the safety of childbirth in Sub-Saharan Africa
- Research Articles – Obstetrics
- Maternal body height is a stronger predictor of birth weight than ethnicity: analysis of birth weight percentile charts
- Chromosomal microarray findings in pregnancies with an isolated pelvic kidney
- Serum sFlt-1/PlGF ratio has better diagnostic ability in early- compared to late-onset pre-eclampsia
- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
- Research Articles – Fetus
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- Quantification of fetal myocardial function in pregnant women with diabetic diseases and in normal controls using speckle tracking echocardiography (STE)
- Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment
- Research Articles – Newborn
- Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
- Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit: the VIRIoN-C study
- Adverse neonatal outcomes and house prices in London
- A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
- Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
- From single-case analysis of neonatal deaths toward a further reduction of the neonatal mortality rate
- Short Communication
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Articles in the same Issue
- Frontmatter
- Review
- Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature
- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
- Corner of Academy
- Midwife-assisted planned home birth: an essential component of improving the safety of childbirth in Sub-Saharan Africa
- Research Articles – Obstetrics
- Maternal body height is a stronger predictor of birth weight than ethnicity: analysis of birth weight percentile charts
- Chromosomal microarray findings in pregnancies with an isolated pelvic kidney
- Serum sFlt-1/PlGF ratio has better diagnostic ability in early- compared to late-onset pre-eclampsia
- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
- Research Articles – Fetus
- Untimely diagnosis of fetomaternal hemorrhage: what went wrong?
- Quantification of fetal myocardial function in pregnant women with diabetic diseases and in normal controls using speckle tracking echocardiography (STE)
- Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment
- Research Articles – Newborn
- Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
- Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit: the VIRIoN-C study
- Adverse neonatal outcomes and house prices in London
- A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
- Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
- From single-case analysis of neonatal deaths toward a further reduction of the neonatal mortality rate
- Short Communication
- Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes
