Abstract
Objective
To explore whether the average price of houses per postcode sector [sector house average prices (SHAP)] is related to perinatal outcomes and whether gestational age would be lower and mortality higher in the least expensive areas compared to the most expensive.
Methods
All neonatal unit admissions at King’s College Hospital from 1/1/2012 to 31/12/2016 were reviewed. The SHAP was retrieved from the Land Registry and the population was divided in equal quintiles with quintiles 1 and 5 representing the most and least expensive areas, respectively. Gestational age and birth weight z-score were collected. Mortality was defined as death before discharge from neonatal care.
Results
Three thousand three hundred and sixty infants were included and divided in quintiles consisting of 672 infants. Gestational age was lower in quintile 5 compared to all other quintiles (adjusted P<0.001). Birthweight z-score was not significantly different between the quintiles. The SHAP was lower in the infants who died before discharge (n=92) compared to the SHAP of the infants who were alive at discharge (n=3268) (P<0.001). Infants of quintile 5 had 6 times higher risk of death before discharge from neonatal care compared to infants of quintile 1.
Conclusion
Low SHAPs were associated with poorer perinatal outcomes suggesting SHAP could potentially be used in perinatal populations to determine socio-economic status and associated outcomes.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Weightman AL, Morgan HE, Shepherd MA, Kitcher H, Roberts C, Dunstan FD. Social inequality and infant health in the UK: systematic review and meta-analyses. Br Med J Open 2012;2:3.10.1136/bmjopen-2012-000964Search in Google Scholar PubMed PubMed Central
2. Kramer MS, Seguin L, Lydon J, Goulet L. Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly? Paediatr Perinat Epidemiol 2000;14:194–210.10.1046/j.1365-3016.2000.00266.xSearch in Google Scholar PubMed
3. Kleinman JC, Kopstein A. Smoking during pregnancy, 1967–1980. Am J Public Health 1987;77:823–5.10.2105/AJPH.77.7.823Search in Google Scholar PubMed PubMed Central
4. Katz SJ, Armstrong RW, LoGerfo JP. The adequacy of prenatal care and incidence of low birthweight among the poor in Washington State and British Columbia. Am J Public Health 1994;84:986–91.10.2105/AJPH.84.6.986Search in Google Scholar
5. Gravett MG, Nelson HP, DeRouen T, Critchlow C, Eschenbach DA, Holmes KK. Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome. J Am Med Assoc 1986;256:1899–903.10.1001/jama.1986.03380140069024Search in Google Scholar
6. Lancaster CA, Gold KJ, Flynn HA, Yoo H, Marcus SM, Davis MM. Risk factors for depressive symptoms during pregnancy: a systematic review. Am J Obstet Gynecol 2010;202:5–14.10.1016/j.ajog.2009.09.007Search in Google Scholar PubMed PubMed Central
7. Neitzke U, Harder T, Plagemann A. Intrauterine growth restriction and developmental programming of the metabolic syndrome: a critical appraisal. Microcirculation 2011;18:304–11.10.1111/j.1549-8719.2011.00089.xSearch in Google Scholar PubMed
8. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull 2001;60:5–20.10.1093/bmb/60.1.5Search in Google Scholar PubMed
9. Townsend P, Phillimore P, Beattie A. Health and deprivation. Inequality and the North. Beckenham, Kent: Croom Helm; 1988.Search in Google Scholar
10. Carstairs V, Morris R. Deprivation and health in Scotland. Health Bull (Edinb) 1990;48:162–75.Search in Google Scholar
11. Statistics OfN. The National Statistics Socio-economic Classification (NS-SEC rebased on the SOC2010). In: Statistics OfN, editor. Basingstoke: Palgrave Macmillan; 2005.Search in Google Scholar
12. HM_Land_Registry. Price Paid Data (PPD). 2017 [cited 2017 14 May]; Available from: https://www.gov.uk/government/statistical-data-sets/price-paid-data-downloads.Search in Google Scholar
13. Smith LK, Draper ES, Manktelow BN, Field DJ. Socioeconomic inequalities in survival and provision of neonatal care: population based study of very preterm infants. Br Med J 2009;339:b4702.10.1136/bmj.b4702Search in Google Scholar PubMed PubMed Central
14. NHSDigital. NHS Data Model and Dictionary for England. In: Health Do, editor; 2017. Available from: https://digital.nhs.uk/services/nhs-data-model-and-dictionary-service.Search in Google Scholar
15. Poon LC, Volpe N, Muto B, Syngelaki A, Nicolaides KH. Birthweight with gestation and maternal characteristics in live births and stillbirths. Fetal Diagn Ther 2012;32:156–65.10.1159/000338655Search in Google Scholar PubMed
16. Gray R, Bonellie SR, Chalmers J, Greer I, Jarvis S, Williams C. Social inequalities in preterm birth in Scotland 1980–2003: findings from an area-based measure of deprivation. Br J Obstet Gynaecol 2008;115:82–90.10.1111/j.1471-0528.2007.01582.xSearch in Google Scholar PubMed
17. Whitehead M, Drever F. Papers narrowing social inequalities in health? Analysis of trends in mortality among babies of lone mothers. Br Med J 1999;318:908.10.1136/bmj.318.7188.908Search in Google Scholar
18. Oakley L, Maconochie N, Doyle P, Dattani N, Moser K. Multivariate analysis of infant death in England and Wales in 2005–2006, with focus on socio-economic status and deprivation. Health Stat Q 2009;42:22–39.10.1057/hsq.2009.15Search in Google Scholar PubMed
19. Smith LK, Manktelow BN, Draper ES, Springett A, Field DJ. Nature of socioeconomic inequalities in neonatal mortality: population based study. Br Med J 2010;341:c6654.10.1136/bmj.c6654Search in Google Scholar PubMed PubMed Central
20. Genowska A, Jamiolkowski J, Szafraniec K, Stepaniak U, Szpak A, Pajak A. Environmental and socio-economic determinants of infant mortality in Poland: an ecological study. Environ Health 2015;14:61.10.1186/s12940-015-0048-1Search in Google Scholar PubMed PubMed Central
21. Markovitz BP, Cook R, Flick LH, Leet TL. Socioeconomic factors and adolescent pregnancy outcomes: distinctions between neonatal and post-neonatal deaths? BMC Public Health 2005;5:79.10.1186/1471-2458-5-79Search in Google Scholar PubMed PubMed Central
22. Petersen CB, Mortensen LH, Morgen CS, Madsen M, Schnor O, Arntzen A, et al. Socio-economic inequality in preterm birth: a comparative study of the Nordic countries from 1981 to 2000. Paediatr Perinat Epidemiol 2009;23:66–75.10.1111/j.1365-3016.2008.00977.xSearch in Google Scholar PubMed
23. Gray R, Bonellie SR, Chalmers J, Greer I, Jarvis S, Kurinczuk JJ, et al. Contribution of smoking during pregnancy to inequalities in stillbirth and infant death in Scotland 1994–2003: retrospective population based study using hospital maternity records. Br Med J 2009;339:b3754.10.1097/01.aoa.0000389613.16876.74Search in Google Scholar
24. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010;25:603–5.10.1007/s10654-010-9491-zSearch in Google Scholar PubMed
25. Bundred P, Manning D, Brewster B, Buchan I. Social trends in singleton births and birth weight in Wirral residents, 1990–2001. Arch Dis Child Fetal Neonatal Ed 2003;88: F421–4.10.1136/fn.88.5.F421Search in Google Scholar PubMed PubMed Central
26. Dibben C, Sigala M, Macfarlane A. Area deprivation, individual factors and low birth weight in England: is there evidence of an “area effect”? J Epidemiol Community Health 2006;60:1053–9.10.1136/jech.2005.042853Search in Google Scholar PubMed PubMed Central
27. Gardosi J, Francis A. Social deprivation, smoking and maternal characteristics as risk factors for small-for-gestational age birthweight. Arch Dis Child Fetal Neonatal Ed 2010;95(Suppl):Fa90–111.10.1136/adc.2010.189761.22Search in Google Scholar
28. Kugelman A, Colin AA. Late preterm infants: near term but still in a critical developmental time period. Pediatrics 2013;132:741–51.10.1542/peds.2013-1131Search in Google Scholar PubMed
29. Wilcox AJ. On the importance – and the unimportance – of birthweight. Int J Epidemiol 2001;30:1233–41.10.1093/ije/30.6.1233Search in Google Scholar PubMed
©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature
- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
- Corner of Academy
- Midwife-assisted planned home birth: an essential component of improving the safety of childbirth in Sub-Saharan Africa
- Research Articles – Obstetrics
- Maternal body height is a stronger predictor of birth weight than ethnicity: analysis of birth weight percentile charts
- Chromosomal microarray findings in pregnancies with an isolated pelvic kidney
- Serum sFlt-1/PlGF ratio has better diagnostic ability in early- compared to late-onset pre-eclampsia
- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
- Research Articles – Fetus
- Untimely diagnosis of fetomaternal hemorrhage: what went wrong?
- Quantification of fetal myocardial function in pregnant women with diabetic diseases and in normal controls using speckle tracking echocardiography (STE)
- Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment
- Research Articles – Newborn
- Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
- Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit: the VIRIoN-C study
- Adverse neonatal outcomes and house prices in London
- A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
- Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
- From single-case analysis of neonatal deaths toward a further reduction of the neonatal mortality rate
- Short Communication
- Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes
Articles in the same Issue
- Frontmatter
- Review
- Ductus venosus agenesis and fetal malformations: what can we expect? – a systematic review of the literature
- Opinion Paper
- Abnormally invasive placenta (AIP): pre-cesarean amnion drainage to facilitate exteriorization of the gravid uterus through a transverse skin incision
- Corner of Academy
- Midwife-assisted planned home birth: an essential component of improving the safety of childbirth in Sub-Saharan Africa
- Research Articles – Obstetrics
- Maternal body height is a stronger predictor of birth weight than ethnicity: analysis of birth weight percentile charts
- Chromosomal microarray findings in pregnancies with an isolated pelvic kidney
- Serum sFlt-1/PlGF ratio has better diagnostic ability in early- compared to late-onset pre-eclampsia
- A multidisciplinary approach to pregnancy loss: the pregnancy loss prevention center
- Relationship between intercellular adhesion molecule-1 and morbidly adherent placenta
- Birth risks according to maternal height and weight – an analysis of the German Perinatal Survey
- Research Articles – Fetus
- Untimely diagnosis of fetomaternal hemorrhage: what went wrong?
- Quantification of fetal myocardial function in pregnant women with diabetic diseases and in normal controls using speckle tracking echocardiography (STE)
- Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment
- Research Articles – Newborn
- Regional differences of hypothermia on oxidative stress following hypoxia-ischemia: a study of DHA and hypothermia on brain lipid peroxidation in newborn piglets
- Detection of cytomegalovirus in saliva from infants undergoing sepsis evaluation in the neonatal intensive care unit: the VIRIoN-C study
- Adverse neonatal outcomes and house prices in London
- A prospective analysis of intake and composition of mother’s own milk in preterm newborns less than 32 weeks’ gestational age
- Neonatal Ogg1/Mutyh knockout mice have altered inflammatory gene response compared to wildtype mice in the brain and lung after hypoxia-reoxygenation
- From single-case analysis of neonatal deaths toward a further reduction of the neonatal mortality rate
- Short Communication
- Comparison of two different treatments in depressed pregnant women: fetal growth characteristics and neonatal outcomes