Outcomes in oligohydramnios: the role of etiology in predicting pulmonary morbidity/mortality
-
Ashley Hesson
and
Elizabeth Langen
Abstract
Objective
Early-onset oligohydramnios is typically secondary to renal-urinary anomalies (RUA) or preterm premature rupture of membranes (PPROM). We compared neonatal pulmonary outcomes between these etiologies.
Methods
We conducted a retrospective cohort study of women with oligohydramnios identified before 24 completed weeks of gestation attributed to either PPROM or RUA. Patients were excluded if other fetal anomalies were noted. Respiratory morbidity was assessed by the need for oxygen at 36 corrected weeks or at hospital discharge.
Results
Of 116 eligible patients, 54 chose elective pregnancy termination. A total of 39.5% of PPROM (n=17/43) and 36.8% of RUA (n=7/19) pregnancies experienced pre-viable loss (P=1.00). Significantly fewer PPROM live births resulted in neonatal mortality (26.9% vs. 75.0%, P<0.01). There was no difference in respiratory morbidity (57.9% vs. 66.6%, P=1.00). The collective incidence of respiratory mortality and morbidity was not different between etiologies (P=0.06).
Conclusion
This analysis suggests that the prognoses for oligohydramnios due to pre-viable PPROM vs. renal anomalies are similarly grave, though RUA infants experienced a higher rate of neonatal respiratory mortality.
Acknowledgments
The authors would like to thank Marjorie C. Treadwell for her assistance in data collection and the attendees of the 2017 ACOG Annual Clinical and Scientific Meeting for their feedback on this project.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
References
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©2018 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Editorial
- What’s new in the multiple gestations literature?
- Corner of Academy
- Is pravastatin a milestone in the prevention and treatment of preeclampsia?
- Research articles – Obstetrics
- Ultrasound study of fetal movements in singleton and twin pregnancies at 12–19 weeks
- Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations
- Outcomes of physical examination-indicated cerclage in twin pregnancies with acute cervical insufficiency compared to singleton pregnancies
- First trimester β-hCG and estradiol levels in singleton and twin pregnancies after assisted reproduction
- Does ultrasound-guided intervention during repeat cesarean sections improve uterine scar architecture and reduce the number of scars? A prospective controlled clinical intervention trial
- Effects of tributyltin on placental cytokine production
- Does rescue cerclage work?
- Computerized prediction system for the route of delivery (vaginal birth versus cesarean section)
- Anencephaly and obstetric outcome beyond the age of viability
- Somatic development at birth as influenced by maternal characteristics – an analysis of the German Perinatal Survey
- Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis
- Research articles – Fetus
- Adrenal gland size in growth restricted fetuses
- Research articles – Newborn
- Effect of pre-pregnancy body mass index on respiratory-related neonatal outcomes in women undergoing elective cesarean prior to 39 weeks
- Growth and body composition in preterm newborns with bronchopulmonary dysplasia: a cohort study
- Utility of serum resistin in the diagnosis of neonatal sepsis and prediction of disease severity in term and late preterm infants
- Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis
- Neonatal resuscitation experience curves: simulation based mastery learning booster sessions and skill decay patterns among pediatric residents
- Serum biomarkers of neuronal injury in newborns evaluated for selective head cooling: a comparative pilot study
- Short communication
- Outcomes in oligohydramnios: the role of etiology in predicting pulmonary morbidity/mortality
