Somatic development at birth as influenced by maternal characteristics – an analysis of the German Perinatal Survey
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Abstract
We investigated the effects of maternal age, body weight, body height, weight gain during pregnancy, smoking during pregnancy, previous live births and being a single mother on somatic development at birth. We analysed data from the German Perinatal Survey for the years 1998–2000 from eight German federal states. We had available data on 508,926 singleton pregnancies and neonates in total; for 508,893 of which we could classify the neonates as small, appropriate or large for gestational age (SGA, AGA or LGA) based on the 10th and 90th birth weight percentiles. Multivariable regression analyses found statistically significant effects of a clinically relevant magnitude for smoking during pregnancy [odds ratio (OR) 2.9 for SGA births for women smoking >10 cigarettes per day], maternal height (OR 1.4 for SGA births for women <162 cm; OR 1.4 for LGA births for women >172 cm), maternal weight (OR 1.5 for SGA births for women <59 kg; OR 1.9 for LGA births for women >69 kg), weight gain during pregnancy (OR 1.9 for SGA births for women with a weight gain <8 kg; OR 2.0 for LGA births for women with a weight gain >18 kg) and previous live births (OR 2.1 for LGA births for women with one or more previous live births). Maternal age and being a single mother also had significant effects but their magnitude was small. Our analysis confirms the clinically relevant effects of smoking, maternal anthropometric measures and weight gain during pregnancy on neonatal somatic development.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
References
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- What’s new in the multiple gestations literature?
- Corner of Academy
- Is pravastatin a milestone in the prevention and treatment of preeclampsia?
- Research articles – Obstetrics
- Ultrasound study of fetal movements in singleton and twin pregnancies at 12–19 weeks
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- Outcomes of physical examination-indicated cerclage in twin pregnancies with acute cervical insufficiency compared to singleton pregnancies
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- Effects of tributyltin on placental cytokine production
- Does rescue cerclage work?
- Computerized prediction system for the route of delivery (vaginal birth versus cesarean section)
- Anencephaly and obstetric outcome beyond the age of viability
- Somatic development at birth as influenced by maternal characteristics – an analysis of the German Perinatal Survey
- Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis
- Research articles – Fetus
- Adrenal gland size in growth restricted fetuses
- Research articles – Newborn
- Effect of pre-pregnancy body mass index on respiratory-related neonatal outcomes in women undergoing elective cesarean prior to 39 weeks
- Growth and body composition in preterm newborns with bronchopulmonary dysplasia: a cohort study
- Utility of serum resistin in the diagnosis of neonatal sepsis and prediction of disease severity in term and late preterm infants
- Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis
- Neonatal resuscitation experience curves: simulation based mastery learning booster sessions and skill decay patterns among pediatric residents
- Serum biomarkers of neuronal injury in newborns evaluated for selective head cooling: a comparative pilot study
- Short communication
- Outcomes in oligohydramnios: the role of etiology in predicting pulmonary morbidity/mortality
Articles in the same Issue
- Frontmatter
- Editorial
- What’s new in the multiple gestations literature?
- Corner of Academy
- Is pravastatin a milestone in the prevention and treatment of preeclampsia?
- Research articles – Obstetrics
- Ultrasound study of fetal movements in singleton and twin pregnancies at 12–19 weeks
- Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations
- Outcomes of physical examination-indicated cerclage in twin pregnancies with acute cervical insufficiency compared to singleton pregnancies
- First trimester β-hCG and estradiol levels in singleton and twin pregnancies after assisted reproduction
- Does ultrasound-guided intervention during repeat cesarean sections improve uterine scar architecture and reduce the number of scars? A prospective controlled clinical intervention trial
- Effects of tributyltin on placental cytokine production
- Does rescue cerclage work?
- Computerized prediction system for the route of delivery (vaginal birth versus cesarean section)
- Anencephaly and obstetric outcome beyond the age of viability
- Somatic development at birth as influenced by maternal characteristics – an analysis of the German Perinatal Survey
- Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis
- Research articles – Fetus
- Adrenal gland size in growth restricted fetuses
- Research articles – Newborn
- Effect of pre-pregnancy body mass index on respiratory-related neonatal outcomes in women undergoing elective cesarean prior to 39 weeks
- Growth and body composition in preterm newborns with bronchopulmonary dysplasia: a cohort study
- Utility of serum resistin in the diagnosis of neonatal sepsis and prediction of disease severity in term and late preterm infants
- Incidence of early-onset sepsis in infants born to women with clinical chorioamnionitis
- Neonatal resuscitation experience curves: simulation based mastery learning booster sessions and skill decay patterns among pediatric residents
- Serum biomarkers of neuronal injury in newborns evaluated for selective head cooling: a comparative pilot study
- Short communication
- Outcomes in oligohydramnios: the role of etiology in predicting pulmonary morbidity/mortality
