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Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD

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Veröffentlicht/Copyright: 26. Juni 2017
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 46 Heft 7

Abstract

Background:

Recurrent pregnancy loss (RPL) is defined by two or more failed clinical pregnancies. Three to four percent of the couples with RPL have chromosomal aberrations (CA) in at least one partner. The parent’s structural chromosomal abnormalities may cause an unbalanced karyotype in the conceptus which could lead to implantation failure, early or late pregnancy loss, or delivery of a child with severe physical and/or mental disabilities.

Objective:

To compare live birth rates of couples with CA to couples with normal karyotypes and to investigate medical and obstetric characteristics and pregnancy outcomes of couples with CA and RPL who attend an RPL clinic at a tertiary hospital.

Methods:

A retrospective cohort study, including 349 patients with two or more consecutive pregnancy losses. The study group consisted of 52 patients with CA, and the control group consisted of 297 couples with normal karyotype. All patients were evaluated and treated in the RPL clinic at Soroka University Medical Center and had at least one subsequent spontaneous pregnancy.

Results:

The demographic and clinical characteristics were not found to be statistically different between the two groups. The group of carriers of CA had 28/52 (53.8%) live births in their index pregnancy vs. the normal 202/297 (68%) (P=0.067, CI 95%) in the control group. No statistically significant etiology was found between the study group and the control group. A statistically significant difference in live birth rates was found when comparing the total amount of pregnancies [index pregnancy (IP)+post index pregnancy (PIP)] between the study group and the control group (54.16% vs. 67.82%, respectively, P=0.0328).

Conclusion:

Patients with RPL and CA who have spontaneous pregnancies, have a good prognosis (63.4%) of a successful pregnancy with at least one of the pregnancies (index or post index) resulting in a live birth.

Keywords: Chromosomal aberration; recurrent miscarriages; recurrent pregnancy loss; stillbirth

  1. Author’s statement

  2. Conflict of interest: Authors state no conflict of interest.

    Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.

  3. Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

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Received: 2016-12-14
Accepted: 2017-04-27
Published Online: 2017-06-26
Published in Print: 2018-09-25

©2018 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Antenatal and prepregnancy care – prevention of perinatal morbidity and mortality
  4. Review article
  5. Fetal interventional procedures and surgeries: a practical approach
  6. Opinion paper
  7. Inverted pyramid of prenatal care – is it enough? Should it be – extended inverted pyramid of prenatal care?
  8. Research articles
  9. Expectant management in di-chorionic pregnancies complicated by discordant anomalous twin
  10. Pregnancy outcomes among patients with recurrent pregnancy loss and uterine anatomic abnormalities
  11. Early postnatal echocardiographic assessment of pulmonary blood flow in newborns with congenital diaphragmatic hernia
  12. Sonographic prediction of small and large for gestational age in breech-presenting fetuses
  13. Comparison of fetal weight distribution improved by paternal height by Spanish standard versus Intergrowth 21st standard
  14. Can early ultrasonography explain the lower miscarriage rates in twin as compared to singleton pregnancies following assisted reproduction?
  15. Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD
  16. Regular research articles
  17. Induction of labor in twin gestation: can we predict success?
  18. Low dose aspirin for preventing fetal growth restriction: a randomised trial
  19. Mid-pregnancy cervical length as a risk factor for cesarean section in women with twin pregnancies
  20. Efficacy of three different regimens in recovery of bowel function following elective cesarean section: a randomized trial
  21. Obstetrical, maternal and neonatal outcomes in pregnancies affected by muscular dystrophy
  22. Fetal brain development in diabetic pregnancies and normal controls
  23. Body composition in preterm infants with intrauterine growth restriction: a cohort study
  24. Commentary
  25. Professionally responsible management of gynecologic cancer in pregnancy when clinical resources are unavoidably limited
  26. Letters to the Editor
  27. Erroneous conclusion due to mis-calculation of data: reply to Rai SE, Sidhu AK, Krishnan RJ. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. J Perinat Med 2017
  28. Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
  29. Congenital Zika syndrome in non-endemic regions
  30. Reply to: Congenital Zika syndrome in non-endemic regions: A neuroimaging pattern-based approach
https://doi.org/10.1515/jpm-2016-0408
Schlagwörter für diesen Artikel
Chromosomal aberration; recurrent miscarriages; recurrent pregnancy loss; stillbirth

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Antenatal and prepregnancy care – prevention of perinatal morbidity and mortality
  4. Review article
  5. Fetal interventional procedures and surgeries: a practical approach
  6. Opinion paper
  7. Inverted pyramid of prenatal care – is it enough? Should it be – extended inverted pyramid of prenatal care?
  8. Research articles
  9. Expectant management in di-chorionic pregnancies complicated by discordant anomalous twin
  10. Pregnancy outcomes among patients with recurrent pregnancy loss and uterine anatomic abnormalities
  11. Early postnatal echocardiographic assessment of pulmonary blood flow in newborns with congenital diaphragmatic hernia
  12. Sonographic prediction of small and large for gestational age in breech-presenting fetuses
  13. Comparison of fetal weight distribution improved by paternal height by Spanish standard versus Intergrowth 21st standard
  14. Can early ultrasonography explain the lower miscarriage rates in twin as compared to singleton pregnancies following assisted reproduction?
  15. Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD
  16. Regular research articles
  17. Induction of labor in twin gestation: can we predict success?
  18. Low dose aspirin for preventing fetal growth restriction: a randomised trial
  19. Mid-pregnancy cervical length as a risk factor for cesarean section in women with twin pregnancies
  20. Efficacy of three different regimens in recovery of bowel function following elective cesarean section: a randomized trial
  21. Obstetrical, maternal and neonatal outcomes in pregnancies affected by muscular dystrophy
  22. Fetal brain development in diabetic pregnancies and normal controls
  23. Body composition in preterm infants with intrauterine growth restriction: a cohort study
  24. Commentary
  25. Professionally responsible management of gynecologic cancer in pregnancy when clinical resources are unavoidably limited
  26. Letters to the Editor
  27. Erroneous conclusion due to mis-calculation of data: reply to Rai SE, Sidhu AK, Krishnan RJ. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. J Perinat Med 2017
  28. Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
  29. Congenital Zika syndrome in non-endemic regions
  30. Reply to: Congenital Zika syndrome in non-endemic regions: A neuroimaging pattern-based approach
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