Abstract
Aim:
To determine whether late second-trimester maternal serum biomarkers are useful for the prediction of preeclampsia during the third trimester, a case-control study including 33 preeclamptic and 71 healthy pregnancies was conducted. Maternal serum concentrations of placental protein 13 (PP13), pregnancy-associated plasma protein (PAPP-A), pentraxin3 (PTX3), soluble FMS-like tyrosine kinase-1 (sFlt-1), myostatin and follistatin-like-3 (FSLT-3) were measured at 24–28 weeks’ gestation. All the concentrations of these markers were compared between the preeclamptic and control groups. Receiver operating characteristic (ROC) curve analysis was applied to assess sensitivity and specificity of serum markers with significant difference.
Results:
The levels of PP13 and sFlt-1 were significantly increased and FSLT3 was significantly decreased in patients with preeclampsia. However, the concentration of PAPPA, PTX3 and myostatin did not differ significantly. In screening for preeclampsia during the third trimester by PP13, sFlt-1 and FSLT3, the detection rate was 61.3%, 48.1% and 39.1%, respectively, at 80% specificity, and the detection rate increased to 69.8% by combination of these three markers.
Conclusion:
Maternal serum levels of PP13, sFlt-1 and FSLT3 play an important role in predicting late-onset preeclampsia, and the combination of these three markers significantly increases the detection rate for prediction.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 81571447
Funding statement: Funding: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: National Natural Science Foundation of China (NO. 81571447).
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Preeclampsia and intrauterine growth restriction: placental disorders still not fully understood
- Review article
- Hepar uterinum: a history of ideas on fetal nutrition
- Original articles
- Twin pregnancy in women above the age of 45 years: maternal and neonatal outcomes
- Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction
- Maternal venous SHARP1 levels in preeclampsia
- Second-trimester maternal serum markers in the prediction of preeclampsia
- Pregnancy outcomes regarding maternal serum AFP value in second trimester screening
- Quantification of mechanical dyssynchrony in growth restricted fetuses and normal controls using speckle tracking echocardiography (STE)
- Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses
- Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation
- Simple approach based on maternal characteristics and mean arterial pressure for the prediction of preeclampsia in the first trimester of pregnancy
- Fetal death: an extreme manifestation of maternal anti-fetal rejection
- Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms
- The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia
- Expression of placental regulatory genes is associated with fetal growth
- Circulating soluble fms-like tyrosine kinase-1 and placental growth factor from 10 to 40 weeks’ pregnancy in normotensive women
- A one year review of eclampsia in an Ethiopian Tertiary Care Center (Saint Paul’s Hospital Millennium Medical College, SPHMMC)
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Preeclampsia and intrauterine growth restriction: placental disorders still not fully understood
- Review article
- Hepar uterinum: a history of ideas on fetal nutrition
- Original articles
- Twin pregnancy in women above the age of 45 years: maternal and neonatal outcomes
- Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction
- Maternal venous SHARP1 levels in preeclampsia
- Second-trimester maternal serum markers in the prediction of preeclampsia
- Pregnancy outcomes regarding maternal serum AFP value in second trimester screening
- Quantification of mechanical dyssynchrony in growth restricted fetuses and normal controls using speckle tracking echocardiography (STE)
- Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses
- Antithrombin improves the maternal and neonatal outcomes but not the angiogenic factors in extremely growth-restricted fetuses at <28 weeks of gestation
- Simple approach based on maternal characteristics and mean arterial pressure for the prediction of preeclampsia in the first trimester of pregnancy
- Fetal death: an extreme manifestation of maternal anti-fetal rejection
- Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms
- The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia
- Expression of placental regulatory genes is associated with fetal growth
- Circulating soluble fms-like tyrosine kinase-1 and placental growth factor from 10 to 40 weeks’ pregnancy in normotensive women
- A one year review of eclampsia in an Ethiopian Tertiary Care Center (Saint Paul’s Hospital Millennium Medical College, SPHMMC)
- Congress Calendar
- Congress Calendar