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Nifedipine increases fetoplacental perfusion

  • Ertugrul Karahanoglu EMAIL logo , Orhan Altinboga , Funda Akpinar , Erhan Demirdag , Safak Ozdemirci , Aysegul Akyol and Serdar Yalvac
Published/Copyright: July 7, 2016
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 45 Issue 1

Abstract

Aim:

Our aim is to evaluate the effect of nifedipine on fetoplacental hemodynamic parameters.

Methods:

A retrospective study was conducted at a tertiary center with 30 patients for whom nifedipine treatment was used as a tocolytic therapy for preterm labor. Initiation of this treatment was at 31.6±2.5 weeks of gestation. We combined the pulse Doppler imaging parameters with grayscale imaging via the Bernoulli theorem, which is called the “continuity equation”, to get the fetoplacental perfusion (FPP). Evaluated parameters were the resistance index (RI), the pulsatility index (PI), systole/diastole ratios (S/D), the velocity-time integral of the umbilical artery (VTI), the radius of the umbilical artery, the peak systolic velocity and the mean pressure gradient in the umbilical artery. From these parameters, the FPP was acquired.

Results:

We found that the RI, the PI and the S/D ratio did not change after treatment with nifedipine. The mean pressure gradient, the VTI and the peak systolic velocity increased after treatment with nifedipine. Nifedipine increases FPP from 166±73.81 beat.cm3/min to 220±83.3 beat.cm3/min.

Discussion:

Although nifedipine had no effect on the PI, the RI or the S/D, it increased the mean pressure gradient, the VTI and FPP.

Keywords: Fetoplacental; nifedipine; perfusion

References

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  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2016-2-29
Accepted: 2016-6-3
Published Online: 2016-7-7
Published in Print: 2017-1-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. What’s new in preterm birth prediction and prevention?
  4. Academy’s Corner
  5. Antenatal corticosteroids: current controversies
  6. Review articles
  7. The safety of progestogen in the prevention of preterm birth: meta-analysis of neonatal mortality
  8. Cervical pessary for the prevention of preterm birth: is it of any use?
  9. Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability
  10. Highlight articles
  11. Placental malperfusion as a possible mechanism of preterm birth in patients with Müllerian anomalies
  12. Nifedipine increases fetoplacental perfusion
  13. Effect of sleep disorders on threatened premature delivery
  14. Risk of recurrent preterm birth among women according to change in partner
  15. Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis
  16. Influence of transvaginal ultrasound examination on quantitative vaginal fibronectin measurements: a prospective evaluation study
  17. Evaluation of quantitative fFn test in predicting the risk of preterm birth
  18. The value of ultrasound measurement of cervical length and parity in prediction of cesarean section risk in term premature rupture of membranes and unfavorable cervix
  19. Comparison of the duo of insulin-like growth factor binding protein-1/alpha fetoprotein (Amnioquick duo+®) and traditional clinical assessment for diagnosing premature rupture of fetal membranes
  20. Efficacy of a prospective community-based intervention to prevent preterm birth
  21. Maternal complications in settings where two-thirds of extremely preterm births are delivered by cesarean section
  22. The risk of neonatal respiratory morbidity according to the etiology of late preterm delivery
  23. Thyroid dysfunction in preterm neonates exposed to iodine
  24. Congress Calendar
  25. Congress Calendar
https://doi.org/10.1515/jpm-2016-0072
Keywords for this article
Fetoplacental; nifedipine; perfusion

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. What’s new in preterm birth prediction and prevention?
  4. Academy’s Corner
  5. Antenatal corticosteroids: current controversies
  6. Review articles
  7. The safety of progestogen in the prevention of preterm birth: meta-analysis of neonatal mortality
  8. Cervical pessary for the prevention of preterm birth: is it of any use?
  9. Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability
  10. Highlight articles
  11. Placental malperfusion as a possible mechanism of preterm birth in patients with Müllerian anomalies
  12. Nifedipine increases fetoplacental perfusion
  13. Effect of sleep disorders on threatened premature delivery
  14. Risk of recurrent preterm birth among women according to change in partner
  15. Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis
  16. Influence of transvaginal ultrasound examination on quantitative vaginal fibronectin measurements: a prospective evaluation study
  17. Evaluation of quantitative fFn test in predicting the risk of preterm birth
  18. The value of ultrasound measurement of cervical length and parity in prediction of cesarean section risk in term premature rupture of membranes and unfavorable cervix
  19. Comparison of the duo of insulin-like growth factor binding protein-1/alpha fetoprotein (Amnioquick duo+®) and traditional clinical assessment for diagnosing premature rupture of fetal membranes
  20. Efficacy of a prospective community-based intervention to prevent preterm birth
  21. Maternal complications in settings where two-thirds of extremely preterm births are delivered by cesarean section
  22. The risk of neonatal respiratory morbidity according to the etiology of late preterm delivery
  23. Thyroid dysfunction in preterm neonates exposed to iodine
  24. Congress Calendar
  25. Congress Calendar
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