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Thyroid dysfunction in preterm neonates exposed to iodine

  • Fiona L.R. Williams EMAIL logo , Jennifer Watson , Chris Day , Aung Soe , Sateesh K. Somisetty , Lesley Jackson , Elena Velten and Anita Boelen
Published/Copyright: August 26, 2016
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 45 Issue 1

Abstract

Background:

Infants <32 weeks’ gestation should not be exposed to topical iodine and its avoidance is recommended during pregnancy and breast feeding. Exposure to contrast media and topical iodine is frequently used in many preterm neonates.

Aim:

To determine whether thyrotropin levels in preterm infants are affected by exposure to intrapartum/neonatal topical iodine and/or the use of iodinated contrast media.

Design:

Infants <32 weeks’ gestation were recruited. Maternal and neonatal exposures to iodinated contrast media and topical iodine were recorded; levels of thyrotropin and thyroxine were measured from blood-spot cards on postnatal days 7, 14, 28 and the equivalent of 36 weeks’ gestation.

Results:

One hundred and twenty-five infants were exposed to topical iodine/contrast media and 48 infants were unexposed. No infants were treated for hypothyroidism; three infants (exposed group) had transient hyperthyrotropinaemia. Mean thyrotropin levels were significantly higher on postnatal days 7, 14 and 28 in infants exposed to topical iodine prior to caesarean section compared to unexposed infants, a relationship which persisted after adjustment.

Conclusions:

In the context of this study, neonatal thyroid dysfunction was seen following exposure to iodine via caesarean section but not via exposure to contrast media.

Keywords: Iodine; preterm; thyroid hormones; toxicity
Corresponding author: Fiona L.R. Williams, PhD, Population Health Sciences, Ninewells Hospital and Medical School, Mackenzie Building, University of Dundee, Kirsty Semple Way, Dundee DD2 4BF, UK, Tel: +44 1382 383726
aMedical student.

Acknowledgements and Disclosures

Senior nursing staff at each of the hospitals supported the study by recruiting infants and recording clinical data; our thanks to: Alison O’Doherty, Bradford Royal Infirmary; Yvonne Millar and Jenny Baker, Luton & Dunstable University Hospital NHS Foundation Trust; Louise Proffitt and Simone Breugem Medway Maritime Hospital; Sharon Lynch, Princess Royal Maternity Unit, Glasgow; and Jill McFerran, Ninewells Hospital and Medical School, Dundee. Our thanks also to Marja van Veen-Sijne (Neonatal Screening Laboratory, Academic Medical Center, Amsterdam) for measuring T4 and TSH in heel prick samples.

  1. Funding: Tenovus Scotland, Anonymous Trust, Dundee.

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Supplemental Material:

The online version of this article (DOI: 10.1515/jpm-2016-0141) offers supplementary material, available to authorized users.

  1. The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2016-4-20
Accepted: 2016-7-22
Published Online: 2016-8-26
Published in Print: 2017-1-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. What’s new in preterm birth prediction and prevention?
  4. Academy’s Corner
  5. Antenatal corticosteroids: current controversies
  6. Review articles
  7. The safety of progestogen in the prevention of preterm birth: meta-analysis of neonatal mortality
  8. Cervical pessary for the prevention of preterm birth: is it of any use?
  9. Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability
  10. Highlight articles
  11. Placental malperfusion as a possible mechanism of preterm birth in patients with Müllerian anomalies
  12. Nifedipine increases fetoplacental perfusion
  13. Effect of sleep disorders on threatened premature delivery
  14. Risk of recurrent preterm birth among women according to change in partner
  15. Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis
  16. Influence of transvaginal ultrasound examination on quantitative vaginal fibronectin measurements: a prospective evaluation study
  17. Evaluation of quantitative fFn test in predicting the risk of preterm birth
  18. The value of ultrasound measurement of cervical length and parity in prediction of cesarean section risk in term premature rupture of membranes and unfavorable cervix
  19. Comparison of the duo of insulin-like growth factor binding protein-1/alpha fetoprotein (Amnioquick duo+®) and traditional clinical assessment for diagnosing premature rupture of fetal membranes
  20. Efficacy of a prospective community-based intervention to prevent preterm birth
  21. Maternal complications in settings where two-thirds of extremely preterm births are delivered by cesarean section
  22. The risk of neonatal respiratory morbidity according to the etiology of late preterm delivery
  23. Thyroid dysfunction in preterm neonates exposed to iodine
  24. Congress Calendar
  25. Congress Calendar
https://doi.org/10.1515/jpm-2016-0141
Keywords for this article
Iodine; preterm; thyroid hormones; toxicity

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. What’s new in preterm birth prediction and prevention?
  4. Academy’s Corner
  5. Antenatal corticosteroids: current controversies
  6. Review articles
  7. The safety of progestogen in the prevention of preterm birth: meta-analysis of neonatal mortality
  8. Cervical pessary for the prevention of preterm birth: is it of any use?
  9. Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability
  10. Highlight articles
  11. Placental malperfusion as a possible mechanism of preterm birth in patients with Müllerian anomalies
  12. Nifedipine increases fetoplacental perfusion
  13. Effect of sleep disorders on threatened premature delivery
  14. Risk of recurrent preterm birth among women according to change in partner
  15. Biomarkers of spontaneous preterm birth: a systematic review of studies using multiplex analysis
  16. Influence of transvaginal ultrasound examination on quantitative vaginal fibronectin measurements: a prospective evaluation study
  17. Evaluation of quantitative fFn test in predicting the risk of preterm birth
  18. The value of ultrasound measurement of cervical length and parity in prediction of cesarean section risk in term premature rupture of membranes and unfavorable cervix
  19. Comparison of the duo of insulin-like growth factor binding protein-1/alpha fetoprotein (Amnioquick duo+®) and traditional clinical assessment for diagnosing premature rupture of fetal membranes
  20. Efficacy of a prospective community-based intervention to prevent preterm birth
  21. Maternal complications in settings where two-thirds of extremely preterm births are delivered by cesarean section
  22. The risk of neonatal respiratory morbidity according to the etiology of late preterm delivery
  23. Thyroid dysfunction in preterm neonates exposed to iodine
  24. Congress Calendar
  25. Congress Calendar
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