Startseite Biological and biochemical characteristics of a Mediterranean population with Gestational Diabetes Mellitus
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Biological and biochemical characteristics of a Mediterranean population with Gestational Diabetes Mellitus

  • Charles Savona-Ventura EMAIL logo , Josanne Vassallo , Johann Craus , Eleni Anastasiou , Aleksandra Jotic , Nebojsa M. Lalic , Claude Ben Slama , Adele Rovira Loscos , Angela Napoli und Giona Roma
Veröffentlicht/Copyright: 15. Mai 2015
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 44 Heft 4

Abstract

The interplay of various nutrients provided to the developing foetus determines the growth potential of the conceptus. This study assessed the inter-relationship between these nutrients in a Mediterranean population including 1062 pregnant, previously non-diabetic women. These underwent an oral glucose tolerance test (oGTT) and were accordingly classified into gestational hyperglycaemic and normoglycaemic groups. Fasting insulin, HbA1c, and lipid profiles were further assessed, and the anthropomorphic characteristics of the mother and child at birth were measured. Lipid profiles were compared between the two groups and related to the biological characteristics of the mother and child at birth. Gestational hyperglycaemia was significantly associated with elevated triglycerides (P<0.0001) and decreased low density lipoprotein cholesterol (LDL-C) (P=0.02). There were no significant changes in total cholesterol and high density lipoprotein cholesterol (HDL-C) levels. Maternal BMI correlated positively with the various glycaemic indices (P<0.0001) and triglycerides (P<0.0001), but inversely with cholesterol (P<0.0001), HDL-C (P<0.0001) and LDL-C (P<0.0001). The infant birth weight correlated positively with maternal body weight (P<0.0001), LDL-C (P<0.0001) and the glycaemic indices (P<0.0001), but negatively with cholesterol (P<0.0001), triglycerides (P<0.0001), HDL-C (P<0.0001) and FBG (P<0.0001). This study confirms that the maternal body mass index (BMI), insulin resistance, and LDL-C levels positively contribute towards foetal growth, whereas a negative correlation was noted with cholesterol, triglycerides, and HDL-C.

Keywords: Birth weight; cholesterol; foetal growth; gestational hyperglycaemia; HOMA-IR; intrauterine nutrition; lipids; maternal BMI; triglycerides
Corresponding author: Charles Savona-Ventura, Department of Obstetrics and Gynaecology, University of Malta, School Mater Dei Hospital, Tal-Qroqq, Msida MSD 2090, Malta, E-mail: ; and Department of Health – Obstetrics and Gynaecology, University of Malta, Mater Dei Hospital, Tal-Qroqq, Msida, Malta

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-1-19
Accepted: 2015-3-20
Published Online: 2015-5-15
Published in Print: 2016-5-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Obesity and gestational diabetes in pregnancy: an evolving epidemic
  4. Original articles - Diabetes
  5. Is omitting the 3rd hour measurement in the 100 g oral glucose tolerance test feasible?
  6. Maternal hypoglycemia on 50 g glucose challenge test: outcomes are influenced by fetal gender
  7. Biological and biochemical characteristics of a Mediterranean population with Gestational Diabetes Mellitus
  8. Maternal and perinatal outcomes after bariatric surgery: a case control study
  9. A population-based comparison between actual maternal weight gain and the Institute of Medicine weight gain recommendations in singleton pregnancies
  10. The relationship between cesarean section rate in term singleton pregnancies, maternal weight, and weight gain during pregnancy
  11. Antenatal body mass index (BMI) and weight gain in pregnancy – its association with pregnancy and birthing complications
  12. A clinical study which relates to a theoretical simulation of the glucose transport in the human placenta under various diabetic conditions
  13. Academy’s Corner
  14. American medical education: the evolution of excellence
  15. Original articles - Obstetrics
  16. Is epidural analgesia during labor related to retained placenta?
  17. Preventing intellectual disability during pregnancy: what are the potentially high yield targets?
  18. Evaluation of measured postpartum blood loss after vaginal delivery using a collector bag in relation to postpartum hemorrhage management strategies: a prospective observational study
  19. Original articles - Fetus
  20. Mutation analysis and prenatal diagnosis in a Chinese family with succinic semialdehyde dehydrogenase and a systematic review of the literature of reported ALDH5A1 mutations
  21. Original articles - Newborn
  22. Neurological disease or intellectual disability among sons of female Swedish dental personnel
  23. Seeking the best training model for difficult conversations in neonatology
  24. Meconium aspiration syndrome in infants of HIV-positive women: a case-control study
  25. Dopamine treatment does not need speed recovery of newborns from transient tachypnea
  26. Congress Calendar
  27. Congress Calendar
https://doi.org/10.1515/jpm-2015-0027
Schlagwörter für diesen Artikel
Birth weight; cholesterol; foetal growth; gestational hyperglycaemia; HOMA-IR; intrauterine nutrition; lipids; maternal BMI; triglycerides

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Obesity and gestational diabetes in pregnancy: an evolving epidemic
  4. Original articles - Diabetes
  5. Is omitting the 3rd hour measurement in the 100 g oral glucose tolerance test feasible?
  6. Maternal hypoglycemia on 50 g glucose challenge test: outcomes are influenced by fetal gender
  7. Biological and biochemical characteristics of a Mediterranean population with Gestational Diabetes Mellitus
  8. Maternal and perinatal outcomes after bariatric surgery: a case control study
  9. A population-based comparison between actual maternal weight gain and the Institute of Medicine weight gain recommendations in singleton pregnancies
  10. The relationship between cesarean section rate in term singleton pregnancies, maternal weight, and weight gain during pregnancy
  11. Antenatal body mass index (BMI) and weight gain in pregnancy – its association with pregnancy and birthing complications
  12. A clinical study which relates to a theoretical simulation of the glucose transport in the human placenta under various diabetic conditions
  13. Academy’s Corner
  14. American medical education: the evolution of excellence
  15. Original articles - Obstetrics
  16. Is epidural analgesia during labor related to retained placenta?
  17. Preventing intellectual disability during pregnancy: what are the potentially high yield targets?
  18. Evaluation of measured postpartum blood loss after vaginal delivery using a collector bag in relation to postpartum hemorrhage management strategies: a prospective observational study
  19. Original articles - Fetus
  20. Mutation analysis and prenatal diagnosis in a Chinese family with succinic semialdehyde dehydrogenase and a systematic review of the literature of reported ALDH5A1 mutations
  21. Original articles - Newborn
  22. Neurological disease or intellectual disability among sons of female Swedish dental personnel
  23. Seeking the best training model for difficult conversations in neonatology
  24. Meconium aspiration syndrome in infants of HIV-positive women: a case-control study
  25. Dopamine treatment does not need speed recovery of newborns from transient tachypnea
  26. Congress Calendar
  27. Congress Calendar
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