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Postnatal kidney maturation regulates renal artery myogenic constriction

  • Hitesh Soni , Randal K. Buddington und Adebowale Adebiyi EMAIL logo
Veröffentlicht/Copyright: 15. Mai 2014
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 43 Heft 1

Abstract

Aim: Intravascular pressure-induced vasoconstriction (myogenic constriction) is central to renal blood flow autoregulation. At term, kidney maturation is functionally incomplete. Premature neonates are at risk of kidney dysfunction. However, it is unclear whether renal artery myogenic constriction is altered after preterm birth. Here, we compared renal artery myogenic constriction in full-term and preterm pigs during the first week of life.

Methods: We investigated myogenic constriction in small interlobular arteries isolated from the kidneys of pigs delivered at term and at 91% of term (with and without 96 h of neonatal intensive care).

Results: Cross-sectional area, media/lumen ratio, and luminal diameter measured under passive conditions were similar in arteries from full-term and preterm pig kidneys. An acute elevation in intravascular pressure from 20 to 100 mm Hg increased arterial wall tension and induced steady-state constriction of the arteries. However, arteries isolated from newly born preterm pigs (within 24 h) developed greater myogenic tone and lower active wall tension compared with arteries from full-term and 4-day-old preterm neonates. Pressure-induced elevation in intracellular Ca2+ was also larger in arteries from newly born preterm pigs compared with full-term and 4-day-old preterm pigs.

Conclusion: Myogenic constriction is elevated in newly born preterm pigs. Our data also suggests that postnatal kidney maturation may modulate renal blood flow autoregulation.

Keywords: Arterial wall [Ca2+]I; arterial wall tension; myogenic constriction; neonates; renal arteries
Corresponding author: Adebowale Adebiyi, PhD, Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA, Tel.: +1-901-448-1868, Fax: +1-901-448-7126, E-mail:

Acknowledgments

This work was supported by funds from the University of Tennessee Health Science Center (Dr. Adebiyi) and the University of Memphis (Dr. Buddington).

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-12-23
Accepted: 2014-4-22
Published Online: 2014-5-15
Published in Print: 2015-1-1

©2015 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Academy’s Corner
  3. Maternal mortality: an ongoing challenge to perinatal medicine
  4. Fetal mild ventriculomegaly: still a challenging problem
  5. Review article
  6. Natural killer cell in the developing life
  7. Original articles – Obstetrics
  8. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques
  9. Individual consultant practice does not affect the overall intervention rate: a 6-year study
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  14. Personnel-itis: a myth or a pathology? A retrospective analysis of obstetrical and perinatal outcomes for physicians and nurses
  15. Placenta-secreted circulating markers in pregnant women with obstructive sleep apnea
  16. Variations of blood cells in prediction of gestational diabetes mellitus
  17. Peripartum cardiomyopathy – risk factors, characteristics and long-term follow-up
  18. Original article – Fetus
  19. Effect of assisted reproductive technology on fetal brain development assessed by prenatal ultrasonography
  20. Original article – Newborn
  21. Racial/ethnic differences in the birth prevalence of congenital anomalies in the United States
  22. Short Communication
  23. Postnatal kidney maturation regulates renal artery myogenic constriction
  24. Letters to the Editor
  25. Ebola viral infection in pregnancy: a plea for specific clinical recommendations
  26. Magnesium may provide further benefit to hypothermia following perinatal asphyxia encephalopathy
  27. Congress Calendar
  28. Congress Calendar
https://doi.org/10.1515/jpm-2013-0346
Schlagwörter für diesen Artikel
Arterial wall [Ca2+]I; arterial wall tension; myogenic constriction; neonates; renal arteries

Artikel in diesem Heft

  1. Frontmatter
  2. Academy’s Corner
  3. Maternal mortality: an ongoing challenge to perinatal medicine
  4. Fetal mild ventriculomegaly: still a challenging problem
  5. Review article
  6. Natural killer cell in the developing life
  7. Original articles – Obstetrics
  8. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques
  9. Individual consultant practice does not affect the overall intervention rate: a 6-year study
  10. Identifying high-risk subgroups for alcohol consumption among younger and older pregnant women
  11. Ultrasonographic severity scoring of non-immune hydrops: a predictor of perinatal mortality
  12. Controversial clinical practices for patients with preeclampsia or HELLP syndrome: a survey
  13. Inter- and intra-observer variability in cervical measurement by ultrasound in the first and second trimesters of pregnancy: does it matter?
  14. Personnel-itis: a myth or a pathology? A retrospective analysis of obstetrical and perinatal outcomes for physicians and nurses
  15. Placenta-secreted circulating markers in pregnant women with obstructive sleep apnea
  16. Variations of blood cells in prediction of gestational diabetes mellitus
  17. Peripartum cardiomyopathy – risk factors, characteristics and long-term follow-up
  18. Original article – Fetus
  19. Effect of assisted reproductive technology on fetal brain development assessed by prenatal ultrasonography
  20. Original article – Newborn
  21. Racial/ethnic differences in the birth prevalence of congenital anomalies in the United States
  22. Short Communication
  23. Postnatal kidney maturation regulates renal artery myogenic constriction
  24. Letters to the Editor
  25. Ebola viral infection in pregnancy: a plea for specific clinical recommendations
  26. Magnesium may provide further benefit to hypothermia following perinatal asphyxia encephalopathy
  27. Congress Calendar
  28. Congress Calendar
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