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Maternal serum placental growth factor and fetal SGA in pregnancy complicated by type 1 diabetes mellitus

  • Paweł Gutaj , Ewa Wender-Ożegowska EMAIL logo , Rafał Iciek , Agnieszka Zawiejska , Marek Pietryga and Jacek Brązert
Published/Copyright: February 12, 2014
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 42 Issue 5

Abstract

Aim: To analyze the role of maternal placental growth factor (PlGF) in the prediction of small for gestational age (SGA) birth weight in pregnancy complicated by type 1 diabetes mellitus (T1DM).

Methods: A prospective observational study on 59 normotensive T1DM pregnant women, assessing maternal PlGF concentrations between the 10th–14th and 22nd–25th weeks of gestation.

Results: Number of SGA vs. non-SGA newborns was 11 (18.6%) vs. 48 (81.4%), respectively. First trimester PlGF serum concentrations (pg/mL) were similar between SGA vs. non-SGA groups [data given as median (interquartile range)]: 65.5 (35.58–159.20) vs. 68.23 (11.59–150.03), respectively; P=0.44. A trend for lower PlGF concentrations was observed in the second trimester in the SGA vs. non-SGA group: 63.34 (12.79–119.16) vs. 116.75 (33.93–235.82); P=0.07. In the SGA group, PlGF concentrations did not differ between the first and the second trimester: 65.5 (35.58–159.20) vs. 63.34 (12.79–119.16), respectively; P=0.36. In the non-SGA group, PlGF concentrations were significantly higher at the gestational age of 22–25 weeks compared to 10–14 weeks [116.75 (33.93–235.82) vs. 68.23 (11.59–150.03); P=0.03).

Conclusions: Decreased PlGF serum concentration in mid-pregnancy, as well as a lack of physiological increase in PlGF levels between early and mid-gestation, may precede development of SGA in women with T1DM.

Keywords: Intrauterine growth restriction; placental growth factor; small for gestational age; type 1 diabetes mellitus
Corresponding author: Ewa Wender-Ożegowska, Department of Obstetrics and Women’s Diseases, Poznan University of Medical Sciences, 60-535 Poznan, Polna St. 33, Poland, Tel./Fax: +48-61-84-19-334, E-mail:

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-8-22
Accepted: 2014-1-17
Published Online: 2014-2-12
Published in Print: 2014-9-1

©2014 by De Gruyter

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  2. Editorial
  3. The CROWN Initiative: journal editors invite researchers to develop core outcomes in women’s health
  4. Academy’s Corner
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  6. Original articles - Obstetrics
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  16. Maternal serum placental growth factor and fetal SGA in pregnancy complicated by type 1 diabetes mellitus
  17. Original article – Fetus
  18. Imaging of fetal thymus in pregnant women with rheumatic diseases
  19. Original articles – Newborn
  20. Milk demystified by chemistry
  21. Absence of antibodies against Bordetella pertussis in pregnant women and newborns in the state of Nuevo Leon
  22. Mortality among sons of female dental personnel – a national cohort study
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  26. Congress Calendar
https://doi.org/10.1515/jpm-2013-0227
Keywords for this article
Intrauterine growth restriction; placental growth factor; small for gestational age; type 1 diabetes mellitus

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. The CROWN Initiative: journal editors invite researchers to develop core outcomes in women’s health
  4. Academy’s Corner
  5. Invasive or non-invasive prenatal genetic diagnosis?
  6. Original articles - Obstetrics
  7. Effect of depth on shear-wave elastography estimated in the internal and external cervical os during pregnancy
  8. Analysis of measurement process of placental volume in early pregnancy: an interobserver reliability study
  9. Acute pancreatitis in pregnancy: a comparison of associated conditions, treatments and complications
  10. Cesarean section and placental disorders in subsequent pregnancies – a meta-analysis
  11. Effect of magnesium sulfate and nifedipine on the risk of developing pulmonary edema in preterm births
  12. Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin
  13. Maternal and neonatal outcome of labour induction at term comparing two regimens of misoprostol
  14. Comparison of placental alpha microglobulin-1 in vaginal fluid with intra-amniotic injection of indigo carmine for the diagnosis of rupture of membranes
  15. Clinical differences between early- and late-onset severe preeclampsia and analysis of predictors for perinatal outcome
  16. Maternal serum placental growth factor and fetal SGA in pregnancy complicated by type 1 diabetes mellitus
  17. Original article – Fetus
  18. Imaging of fetal thymus in pregnant women with rheumatic diseases
  19. Original articles – Newborn
  20. Milk demystified by chemistry
  21. Absence of antibodies against Bordetella pertussis in pregnant women and newborns in the state of Nuevo Leon
  22. Mortality among sons of female dental personnel – a national cohort study
  23. IAPM Statements 2005–2012
  24. DECLARATIONS of the “International Academy of Perinatal Medicine” (IAPM)
  25. Congress Calendar
  26. Congress Calendar
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