Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection
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Pamela Borja-Del-Rosario
Abstract
Background: Antenatal magnesium in preterm labor for neuroprotection decreases the incidence of cerebral palsy. However, there are no guidelines on the dose and duration of magnesium infusion for neuroprotection. As increased neonatal serum magnesium concentrations may be related to higher risk of morbidity and mortality, the role of total amount of magnesium and maternal serum magnesium concentrations associated with safe neonatal serum magnesium concentrations is not known.
Methods: A retrospective study was conducted on 289 mothers who received antenatal magnesium for neuroprotection as a loading dose of 4–6 g infused over 30 min, followed by a maintenance infusion of 1–2 g/h. Total magnesium dose infused to the mother and maternal serum magnesium concentrations were correlated with neonatal serum magnesium concentrations.
Results: Of the 289 mothers, 192 mother/baby dyads had all three measurements (maternal total magnesium dose, and maternal and neonatal serum magnesium concentrations). Magnesium infusion was continued beyond 24 h in 60 mothers. Total maternal magnesium dose at 24 and 48 h of infusion correlated with neonatal serum magnesium concentrations (r=0.55, P<0.0001 and r=0.35, P<0.0001, respectively), but not with maternal serum magnesium concentrations (r=0.004, P=0.98 and r=0.14, P=0.21). However, there was no correlation between the maternal and neonatal serum magnesium concentrations (r=0.10, P=0.15).
Conclusion: Total dose of magnesium infused to the mother correlates with neonatal serum magnesium concentrations. To keep neonatal serum magnesium concentrations within a range that is effective for neuroprotection and safe for the neonates, the total dose received by the mother needs to be monitored and limited.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
Article note: Selected paper from the New York Perinatal Society papers presented at the 36th Annual Scientific Meeting, Monday April 15, 2013.
©2014 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- frontmatter
- Review articles
- Evaluation of the role of first-trimester obstetric ultrasound in the detection of major anomalies: a systematic review
- Austrian Newborn Screening Program: a perspective of five decades
- Original articles – Obstetrics
- Cervical strain determined by ultrasound elastography and its association with spontaneous preterm delivery
- Risk factors for unfavorable pregnancy outcome in women with adverse childhood experiences
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- Premature rupture of membranes at term in low risk women: how long should we wait in the “latent phase”?
- Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial
- Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection
- Labor induction in nulliparous women with an unfavorable cervix: double balloon catheter versus dinoprostone
- Peripartum thromboprophylaxis before and after implementation of a uniform heparin protocol
- Original articles – Fetus
- Impact of sex on perinatal mortality and morbidity in twins
- Opinion paper
- Preeclampsia is caused by continuous sympathetic center excitation due to an enlarged pregnant uterus
- Original articles – Newborn
- Practical application of kangaroo mother care in preterm infants: clinical characteristics and safety of kangaroo mother care
- Survival and neonatal morbidity among extremely preterm born infants in relation to gestational age based on the last menstrual period or ultrasonographic examination
- Short communication
- Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center
- Letters to the Editor
- Hepatic rupture: a rare but serious complication of HELLP syndrome
- Reply
- Reply to: hepatic rupture – a rare but serious complication of HELLP syndrome
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- frontmatter
- Review articles
- Evaluation of the role of first-trimester obstetric ultrasound in the detection of major anomalies: a systematic review
- Austrian Newborn Screening Program: a perspective of five decades
- Original articles – Obstetrics
- Cervical strain determined by ultrasound elastography and its association with spontaneous preterm delivery
- Risk factors for unfavorable pregnancy outcome in women with adverse childhood experiences
- Peroxisome proliferator-activated receptor-gamma (PPARγ) is down regulated in trophoblast cells of gestational diabetes mellitus (GDM) and in trophoblast tumour cells BeWo in vitro after stimulation with PPARγ agonists
- Premature rupture of membranes at term in low risk women: how long should we wait in the “latent phase”?
- Ferrous bisglycinate 25 mg iron is as effective as ferrous sulfate 50 mg iron in the prophylaxis of iron deficiency and anemia during pregnancy in a randomized trial
- Neonatal serum magnesium concentrations are determined by total maternal dose of magnesium sulfate administered for neuroprotection
- Labor induction in nulliparous women with an unfavorable cervix: double balloon catheter versus dinoprostone
- Peripartum thromboprophylaxis before and after implementation of a uniform heparin protocol
- Original articles – Fetus
- Impact of sex on perinatal mortality and morbidity in twins
- Opinion paper
- Preeclampsia is caused by continuous sympathetic center excitation due to an enlarged pregnant uterus
- Original articles – Newborn
- Practical application of kangaroo mother care in preterm infants: clinical characteristics and safety of kangaroo mother care
- Survival and neonatal morbidity among extremely preterm born infants in relation to gestational age based on the last menstrual period or ultrasonographic examination
- Short communication
- Reference values of nuchal translucency thickness in a Brazilian population sample: experience from a single center
- Letters to the Editor
- Hepatic rupture: a rare but serious complication of HELLP syndrome
- Reply
- Reply to: hepatic rupture – a rare but serious complication of HELLP syndrome
- Congress Calendar
- Congress Calendar
