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Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants

  • Muhammad Adrianes Bachnas EMAIL logo , Johanes Cornelius Mose , Jusuf Sulaeman Effendi and Wiku Andonotopo
Published/Copyright: September 24, 2013
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 42 Issue 1

Abstract

Aim: To investigate the influence of antenatal magnesium sulfate (MgSO4) application on cord blood brain-derived neurotrophic factor (BDNF) levels – the first-line neuroprotection for preventing cerebral palsy in prematurely born infants.

Subjects and methods: A randomized controlled trial was conducted by observing 72 pregnant women who were divided into three groups: group I (preterm pregnancy with MgSO4), group II (preterm pregnancy without MgSO4), and group III (full-term pregnancy as control group). Groups I and II were selected by block permutation randomization on subjects. Inclusion criteria consisted of preterm pregnancy at 34 weeks of gestation or less who were in labor or having planned terminations and receiving antenatal corticosteroids. Exclusion criteria consisted of previous complications caused by MgSO4, previous history of antenatal MgSO4 application in the current pregnancy infant was born before 4 h administration of MgSO4 or unborn more than 72 h after maximum course of antenatal MgSO4 of 24 h, prolonged antenatal MgSO4 treatment (>24 h), refusal to participate, and emergent adverse events during the study. Group I was given intravenous MgSO4; initial dose was 4 g, which was maintained at 1 g/h up to maximum of 24 h. Meanwhile, groups II and III were not given any special treatment. BDNF was examined by ELISA by taking 5 mL cord blood sample shortly after birth. The result was statistically measured by ANOVA.

Results: The cord blood BDNF levels in premature infants with antenatal MgSO4 was significantly higher than in premature infants without antenatal MgSO4 (11,568 vs. 5027 pg/mL, P=0.000). Moreover, the result was statistically comparable to full-term infants (11,568 vs. 13,300 pg/mL, P=0.085).

Conclusion: The application of antenatal MgSO4 in preterm delivery increased cord blood BDNF levels, which could have a potential role on fetal neuroprotection. Further investigation is needed.

Keywords: Atenatal magnesium sulfate; brain-derived neurotrophic factor; neuroprotection; prematurity
Corresponding author: Muhammad Adrianes Bachnas, MD, Fetomaternal Division, Department of Obstetrics and Gynecology, Medical Faculty of Sebelas Maret University, Moewardi Hospital, Solo, Surakarta, Indonesia, Tel.: +628122692928, E-mail:

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-6-13
Accepted: 2013-8-14
Published Online: 2013-09-24
Published in Print: 2014-01-01

©2014 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpm-2013-0137
Keywords for this article
Atenatal magnesium sulfate; brain-derived neurotrophic factor; neuroprotection; prematurity

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Recommendation and Guidelines for Perinatal Practice
  4. Inactivation of high-risk human papillomaviruses by Holder pasteurization: implications for donor human milk banking
  5. Review article
  6. Breastfeeding is natural but not always easy: intervention for common medical problems of breastfeeding mothers – a review of the scientific evidence
  7. Original article – Obstetrics
  8. Maternal mortality due to pandemic influenza A H1N1 2009 virus in Colombia
  9. Commentary
  10. Maternal mortality due to pandemic influenza A H1N1 2009 virus in Colombia
  11. Original articles – Obstetrics
  12. The peripheral whole-blood transcriptome of acute pyelonephritis in human pregnancya
  13. Extremely short cervix in the second trimester: bed rest or modified Shirodkar cerclage?
  14. The importance of repeated measurements of the sFlt-1/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction
  15. Does the presence of thyroid antibodies affect the course and outcome of pregnancy in type 1 diabetic women?
  16. The impact of perinatal death on obstetrics nurses: a longitudinal and cross-sectional examination
  17. Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring
  18. The prevalence and clinical features of twin-twin transfusion syndrome with onset during the third trimester
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  27. Short communication
  28. Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision
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