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Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision

  • Cathy Monteith , Fionnuala Ní Áinle , Sharon Cooley , John S. Lambert , Barry Kelleher , Valerie Jackson and Maeve Eogan EMAIL logo
Published/Copyright: September 4, 2013
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 42 Issue 1

Abstract

Objective: Recent studies have implicated hepatitis C virus (HCV) in the pathogenesis of immune thrombocytopenia. In pregnancy-associated immune thrombocytopenia, multidisciplinary management is required due to a potential for bleeding complications. We performed a retrospective review of HCV-infected pregnant women and age-matched controls who were not infected with HCV.

Methods: One hundred and six women with a HCV viral load were identified from 2009 to 2011.

Results: Thrombocytopenia was identified in 10.3% of HCV-infected pregnant women and 1.6% of age-matched controls (P<0.001). Mean platelet count during pregnancy was 120±23×109/L in HCV-infected women and at delivery was significantly lower in HCV-infected women than in controls (P=0.01). Despite the significant difference in platelet counts, there was no significant difference in estimated blood loss (EBL) at delivery. Regional anaesthesia was performed in 73% of thrombocytopenic HCV-infected women and no complications were recorded. There were no fetal bleeding complications.

Conclusion: In the first study to date to investigate the impact of HCV on maternal platelet count we demonstrated a significantly higher frequency of thrombocytopenia and a significantly lower platelet count in HCV-infected pregnant women compared with controls. Interestingly, thrombocytopenia had no detectable impact on EBL at delivery.

Keywords: Hepatitis; platelets; thrombocytopenia
Corresponding author: Dr Maeve Eogan, Department of Obstetrics, Rotunda Maternity Hospital, Dublin 1, Ireland, E-mail:

References

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-4-10
Accepted: 2013-7-22
Published Online: 2013-09-04
Published in Print: 2014-01-01

©2014 by Walter de Gruyter Berlin Boston

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  26. Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants
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  28. Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision
  29. Congress Calendar
  30. Congress Calendar
https://doi.org/10.1515/jpm-2013-0080
Keywords for this article
Hepatitis; platelets; thrombocytopenia

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Recommendation and Guidelines for Perinatal Practice
  4. Inactivation of high-risk human papillomaviruses by Holder pasteurization: implications for donor human milk banking
  5. Review article
  6. Breastfeeding is natural but not always easy: intervention for common medical problems of breastfeeding mothers – a review of the scientific evidence
  7. Original article – Obstetrics
  8. Maternal mortality due to pandemic influenza A H1N1 2009 virus in Colombia
  9. Commentary
  10. Maternal mortality due to pandemic influenza A H1N1 2009 virus in Colombia
  11. Original articles – Obstetrics
  12. The peripheral whole-blood transcriptome of acute pyelonephritis in human pregnancya
  13. Extremely short cervix in the second trimester: bed rest or modified Shirodkar cerclage?
  14. The importance of repeated measurements of the sFlt-1/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction
  15. Does the presence of thyroid antibodies affect the course and outcome of pregnancy in type 1 diabetic women?
  16. The impact of perinatal death on obstetrics nurses: a longitudinal and cross-sectional examination
  17. Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring
  18. The prevalence and clinical features of twin-twin transfusion syndrome with onset during the third trimester
  19. Original article – Newborn
  20. Short and medium-term outcomes of live-born twins after fetoscopic laser therapy for twin-twin transfusion syndromea
  21. Original article – Fetus
  22. Fetal volume at 11–14 gestational weeks: reference ranges and association with first trimester biochemical and biophysical markers
  23. Original articles – Newborn
  24. Resuscitation at birth in neonates with meningomyelocele
  25. Steroid profiling for congenital adrenal hyperplasia by tandem mass spectrometry as a second-tier test reduces follow-up burdens in a tertiary care hospital: A retrospective and prospective evaluation
  26. Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants
  27. Short communication
  28. Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision
  29. Congress Calendar
  30. Congress Calendar
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