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Clinical evaluation of soluble intercellular adhesion molecule-1 and insulin like growth factor-binding protein-1-based rapid immunoassays for the diagnosis of prelabor rupture of membranes
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Tao Wang
Veröffentlicht/Copyright:
14. September 2012
Abstract
Aims: To evaluate the clinical value of two rapid tests, based on soluble intercellular adhesion molecule-1 (Leakection) and insulinlike growth factor-binding protein-1 (Amnioquick), for the diagnosis of prelabor rupture of membranes.
Methods: A total of 200 pregnant women were recruited in this study: 100 pregnant women with membrane rupture and 100 healthy pregnant women as controls. Patients and controls were randomly divided into Leakection and Amnioquick groups, respectively. Sensitivity and specificity were calculated on the basis of the detection results.
Results: For the 100 women tested with Leakection, the sensitivity and specificity was 94% and 96%, respectively; the total accuracy was 95%. For the 100 women tested with Amnioquick, the sensitivity and specificity was 80% and 100%, respectively; the total accuracy was 90%.
Conclusions: Both Leakection and Amnioquick are non-invasive and inexpensive rapid tests for the diagnosis of premature or prelabor rupture of membranes with high sensitivity and specificity. These tests could greatly help the timely diagnosis of premature or prelabor rupture of membranes in clinical practice.
Keywords: Amnioquick; insulinlike growth factor-binding protein 1; Leakection; prelabor rupture of membrane; soluble intercellular adhesion molecule-1
Received: 2012-5-30
Revised: 2012-7-6
Accepted: 2012-7-30
Published Online: 2012-09-14
Published in Print: 2013-03-01
©2013 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
Amnioquick;
insulinlike growth factor-binding protein 1;
Leakection;
prelabor rupture of membrane;
soluble intercellular adhesion molecule-1
Artikel in diesem Heft
- Masthead
- Masthead
- Recommendation and Guidelines for Perinatal Practice
- Presence of human milk bank is associated with elevated rate of exclusive breastfeeding in VLBW infants
- Reviews
- Bariatric surgery and pregnancy: the magical solution?
- Placenta accreta and the risk of adverse maternal and neonatal outcomes
- Original Articles - Obstetrics
- Correlation between an absence of cervical gland area on transvaginal sonography and cervical mucus hyaluronic acid levels in women with threatened preterm delivery
- Adult separation anxiety during pregnancy and its relationship to depression and anxiety
- Value of Doppler sonography near term: can umbilical and uterine artery indices in low-risk pregnancies predict perinatal outcome?
- Induction of labor after a prior cesarean delivery: lessons from a population-based study
- Clinical evaluation of soluble intercellular adhesion molecule-1 and insulin like growth factor-binding protein-1-based rapid immunoassays for the diagnosis of prelabor rupture of membranes
- Original Articles - Fetus
- The clinical value of KANET in studying fetal neurobehavior in normal and at-risk pregnancies
- Original Articles - Newborn
- Effect of maternal vitamin A deficiency during pregnancy on neonatal kidney size
- Polymorphism 1936A>G in the AKAP10 gene (encoding A-kinase-anchoring protein 10) is associated with higher cholesterol cord blood concentration in Polish full-term newborns
- Defining hypoxic ischemic encephalopathy in newborn infants: benchmarking in a South African population
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