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Plasma leptin and adiponectin concentrations in healthy, non-obese children
-
Helena I. Papaioannou
,
Dimitrios N. Tziakas
Published/Copyright:
May 24, 2011
Abstract
Background: Alterations in plasma leptin and adiponectin concentrations are associated with an adverse metabolic profile in obese children.
Objective: To simultaneously assess multiple factors with possible effects on plasma leptin and adiponectin concentrations in healthy, non-obese children.
Subjects: We studied 170 healthy non-obese children (86 males, age 10±1.5 years), with available medical records from birth.
Methods: Plasma leptin and adiponectin concentrations were assessed by immunoassay. The ratio of current weight/birth weight (WBWR) was used as an index of children growth from birth. Children’s intensity of physical activity and parental characteristics were also assessed.
Results: Leptin was positively associated with WBWR (p<0.0001); parental smoking (analysis of variance, ANOVA; p=0.03) and parental obesity (ANOVA; p<0.001) were negatively associated with breastfeeding (p<0.01) and children’s access to exercise (p<0.0001). Adiponectin was negatively associated with WBWR (p<0.0001) and parental smoking (p=0.04), with an additive negative effect of parental smoking status and parental obesity on children’s adiponectin levels (ANOVA; p=0.02).
Conclusions: Children’s and parental factors are related and could possibly influence leptin and adiponectin concentrations in healthy non-obese children. Early preventive strategies that target both children and parents could improve the profile of adipocytokine in these children.
Published Online: 2011-05-24
Published in Print: 2011-06-01
©2011 by Walter de Gruyter Berlin Boston
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