The Relationship between Vitamin D Receptor Gene Polymorphisms and Bone Density, Osteocalcin Level and Growth in Adolescents
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ABSTRACT
Background/Objective: The relationship between vitamin D receptor gene polymorphisms and bone density, osteocalcin and growth was investigated.
Subjects: Eighty eight adolescents aged between 8-15, with no history of illness influencing the level of bone parameters, were examined in our study.
Methods: Areal BMD for lumbar spine (L1-4) was assessed by dual energy X-ray absorptiometry (DEXA). Height and weight were measured on the day of the DEXA scans. Serum osteocalcin level was determined by using ELISA method. DNA was extracted from white blood cells, amplified by the polymerase chain reaction (PCR) and the polymorphic sites were analyzed by using ApaI, TaqI and FokI restriction enzymes.
Results: The most frequent genotypes were FF (% 54.6), Aa (% 53.4) and Tt (% 48.8). No significant relationship was found between VDR genotypes and areal BMD, osteocalcin level or growth in either sex. But there was a strong tendency for a higher BMD at the lumbar spine of TT and AA genotypes compared to tt and Aa genotypes. The children with TT genotype were taller and heavier than the children with tt genotype.
Conclusion: Our results suggest that VDR gene TaqI polymorphism may be associated with body weight and bone mass, but more studies with larger groups should be conducted.
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- The Functional Food Era
- Pituitary Adenomas in Children and Adolescents
- Hypothalamic Hamartoma Causing Precocious Puberty in a Female Child
- “Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age
- Cognition, Emotions and Quality of Life in Lithuanian Girls with Turner Syndrome after Growth Hormone Therapy Discontinuation
- Predictors and Growth Consequences of Central Hypothyroidism in Pediatric Patients Receiving Recombinant Human Growth Hormone
- Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters
- Growth Hormone Response to GH-Releasing Peptide-2 in Children
- The Evaluation of the Adrenal and Thyroid Axes and Glucose Metabolism after Burn Injury in Children
- The Relationship between Vitamin D Receptor Gene Polymorphisms and Bone Density, Osteocalcin Level and Growth in Adolescents
- Elevated Plasma Levels of Apelin in Children with Type 1 Diabetes Mellitus
- Chronic Intermittent Form of Isovaleric Acidemia Mimicking Diabetic Ketoacidosis
- Obesity and Reversed Growth Retardation in a Child with Type Ia Glycogen Storage Disease
- Another Unusual Presentation of McCune Albright Syndrome with Fibrous Dysplasia, Unilateral Testicular Enlargement, and Testicular Microlithiasis
- Cystic Changes in the Ovaries of a Pre-pubertal Girl with Henoch-Schönlein Purpura
- A Case Report of Neonatal Diabetes Due to Neonatal Hemochromatosis
- Rathke Cleft Cyst in Seven Year-old Girl Presenting with Central Diabetes Insipidus and Review of Literature
