Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters
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ABSTRACT
Children born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, proinsulin, leptin, growth factors, insulin, HOMA IR and HOMA βcell in 23 SGA+CUG, 26 SGA-CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resistance as an adaptive mechanism to increase energy balance, but an altered functional response of adipocytes cannot be discarded.
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- The Functional Food Era
- Pituitary Adenomas in Children and Adolescents
- Hypothalamic Hamartoma Causing Precocious Puberty in a Female Child
- “Functional Food” for Acceleration of Growth in Short Children Born Small for Gestational Age
- Cognition, Emotions and Quality of Life in Lithuanian Girls with Turner Syndrome after Growth Hormone Therapy Discontinuation
- Predictors and Growth Consequences of Central Hypothyroidism in Pediatric Patients Receiving Recombinant Human Growth Hormone
- Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters
- Growth Hormone Response to GH-Releasing Peptide-2 in Children
- The Evaluation of the Adrenal and Thyroid Axes and Glucose Metabolism after Burn Injury in Children
- The Relationship between Vitamin D Receptor Gene Polymorphisms and Bone Density, Osteocalcin Level and Growth in Adolescents
- Elevated Plasma Levels of Apelin in Children with Type 1 Diabetes Mellitus
- Chronic Intermittent Form of Isovaleric Acidemia Mimicking Diabetic Ketoacidosis
- Obesity and Reversed Growth Retardation in a Child with Type Ia Glycogen Storage Disease
- Another Unusual Presentation of McCune Albright Syndrome with Fibrous Dysplasia, Unilateral Testicular Enlargement, and Testicular Microlithiasis
- Cystic Changes in the Ovaries of a Pre-pubertal Girl with Henoch-Schönlein Purpura
- A Case Report of Neonatal Diabetes Due to Neonatal Hemochromatosis
- Rathke Cleft Cyst in Seven Year-old Girl Presenting with Central Diabetes Insipidus and Review of Literature
