Adrenal oncocytoma: an unusual etiology of Cushing’s syndrome in an adolescent female
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Saba Samad Memon
,
Sanjay Chaudhari
,
Zalak Parmar
,
Kaushal Patel
Abstract
Objectives
This report presents a rare pediatric functional AO causing CS and androgen excess. It aims to discuss the diagnostic challenges of cortisol and DHEAS co-secretion, which may mimic adenomas or carcinomas. It also emphasizes the role of clinical, biochemical, and imaging assessments, as well as histological classification using LWB criteria, and the need for long-term follow-up.
Case Presentation
A 17-year-old female presented with weight gain, moon facies, cushingoid striae, oligomenorrhea, and acne over six months. Examination showed hypertension, grade I obesity, cushingoid stigmata without virilization. Endocrine evaluation was confirmed ACTH independent CS due to right AO.
Conclusions
This case illustrates functional AO as a rare cause of adolescent CS with androgen excess. Co-secretion patterns complicate diagnosis, imaging may not be definitive, and long-term follow-up is vital due to uncertain prognosis.
Acknowledgments
Ms. Palak Raj-helped in retrieving the case details and prepare the manuscript.
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Research ethics: Not applicable.
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Informed consent: Informed consent was obtained from their legal guardians.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: Not applicable.
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Conflict of interest: Not applicable.
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Research funding: Not applicable.
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Data availability: Not applicable.
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