Startseite Medizin Relationship between blood lipids and bone mineral density in healthy preschoolers: a 12-month cohort study
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Relationship between blood lipids and bone mineral density in healthy preschoolers: a 12-month cohort study

  • Xueqian Mao , Xueyi Jin , Ying Hu , Panpan He , Qianwen Yang , Zhiwei Zhang und Lipeng Jing EMAIL logo
Veröffentlicht/Copyright: 22. Mai 2025
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 38 Heft 7

Abstract

Objectives

A prospective study was conducted examining the association between blood lipid levels and bone mineral density in preschool-aged children.

Methods

Healthy preschool-aged children (n=411) were included in this 12-month cohort study. The bone mineral density and bone mineral content of the non-dominant forearm and calcaneus were measured using dual-energy X-ray absorptiometry (DXA). Additionally, the children’s fasting blood was drawn at baseline to measure blood lipids.

Results

The sample comprised 411 healthy preschool-aged children, 208 girls and 203 boys, with a mean age of 4.80±0.70 years. After one year of observation, the bone mineral density of the non-dominant calcaneus in preschool children increased by 30.37 mg/cm2, bone mineral content increased by 29.85 mg, and triglyceride levels increased by 0.05 mmol/L. A significant inverse assocation was observed between serum triglyceride levels within the normal physiological range and the changes in bone mineral density (BMD) at the non-dominant calcaneus in preschool children, whereas no such association was detected with BMD changes in the non-dominant forearm. A 1 mmol/L increase in triglycerides within the physiological normal range was associated with a 6.73 mg/cm2 decrease in bone mineral density (95 % CI: −12.90, −0.56) and a 5.98 mg decrease in bone mineral content (95 % CI: −11.77, −0.19). There was no significant relationship between other lipids and bone mineral density.

Conclusions

Serum triglyceride concentrations within the physiological normal range showed a significant negative correlation with the 12-month increment of calcaneal bone mineral density in preschool children (p<0.05).

Keywords: bone mineral density; preschool children; blood lipid; cohort study
Corresponding authors: Lipeng Jing, Department of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu Province, China, E-mail:

Funding source: the Fundamental Research Funds for the Central Universities

Award Identifier / Grant number: lzujbky-2023–40

Funding source: the Gansu Province Science Foundation for Youths

Award Identifier / Grant number: 21JR7RA507

Funding source: the National Natural Science Foundation of China

Award Identifier / Grant number: 82003525

Acknowledgments

The authors would like to thank all research members involved in the data collection of the study.

  1. Research ethics: The study complied with medical ethics standards and was reviewed and approved by the Ethics Committee of the School of Public Health, Lanzhou University (ethics approval number: IRB21083101) before the start of the study.

  2. Informed consent: Informed consent was obtained from all individuals included in this study, or their legal guardians or wards.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: None declared.

  5. Conflict of interest: All other authors state no conflict of interest.

  6. Research funding: This work was supported by the Fundamental Research Funds for the Central Universities under Grant lzujbky-2023–40; the Gansu Province Science Foundation for Youths under Grant 21JR7RA507 and the National Natural Science Foundation of China under Grant 82003525.

  7. Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

1. Yudoh, K, Sugishita, Y, Suzuki-Takahashi, Y. Bone development and regeneration 2.0. Int J Mol Sci 2023;24:8761. https://doi.org/10.3390/ijms24108761.Suche in Google Scholar PubMed PubMed Central

2. Matkovic, V. Skeletal development and bone turnover revisited. J Clin Endocrinol Metab 1996;81:2013–16. https://doi.org/10.1210/jc.81.6.2013.Suche in Google Scholar

3. Golden, NH, Abrams, SA, Committee on Nutrition. Optimizing bone health in children and adolescents. Pediatrics 2014;134:e1229–1243. https://doi.org/10.1542/peds.2014-2173.Suche in Google Scholar PubMed

4. Bonjour, J-P, Chevalley, T, Ferrari, S, Rizzoli, R. The importance and relevance of peak bone mass in the prevalence of osteoporosis. Salud Publica Mex 2009;51:S5–17. https://doi.org/10.1590/s0036-36342009000700004.Suche in Google Scholar PubMed

5. Hernandez, CJ, Beaupré, GS, Carter, DR. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int 2003;14:843–7. https://doi.org/10.1007/s00198-003-1454-8.Suche in Google Scholar PubMed

6. Boreham, CAG, McKay, HA. Physical activity in childhood and bone health. Br J Sports Med 2011;45:877–9. https://doi.org/10.1136/bjsports-2011-090188.Suche in Google Scholar PubMed

7. Gopinath, V. Osteoporosis. Med Clin 2023;107:213–25. https://doi.org/10.1016/j.mcna.2022.10.013.Suche in Google Scholar PubMed

8. Forlino, A, Marini, JC. Osteogenesis imperfecta. Lancet 2016;387:1657–71. https://doi.org/10.1016/s0140-6736(15)00728-x.Suche in Google Scholar PubMed PubMed Central

9. Proia, P, Amato, A, Drid, P, Korovljev, D, Vasto, S, Baldassano, S. The impact of diet and physical activity on bone health in children and adolescents. Front Endocrinol (Lausanne) 2021;12:704647. https://doi.org/10.3389/fendo.2021.704647.Suche in Google Scholar PubMed PubMed Central

10. Fishman, LM. Yoga and bone health. Orthop Nurs 2021;40:169–79. https://doi.org/10.1097/nor.0000000000000757.Suche in Google Scholar

11. Reid, IR, Bolland, MJ, Grey, A. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet 2014;383:146–55. https://doi.org/10.1016/s0140-6736(13)61647-5.Suche in Google Scholar

12. Hales, CM, Fryar, CD, Carroll, MD, Freedman, DS, Ogden, CL. Trends in obesity and severe obesity prevalence in US youth and adults by sex and age, 2007–2008 to 2015–2016. JAMA 2018;319:1723–5. https://doi.org/10.1001/jama.2018.3060.Suche in Google Scholar PubMed PubMed Central

13. Skinner, AC, Ravanbakht, SN, Skelton, JA, Perrin, EM, Armstrong, SC. Prevalence of obesity and severe obesity in US children, 1999–2016. Pediatrics 2018;141:e20173459. https://doi.org/10.1542/peds.2017-3459.Suche in Google Scholar PubMed PubMed Central

14. Devlin, MJ, Rosen, CJ. The bone-fat interface: basic and clinical implications of marrow adiposity. Lancet Diabetes Endocrinol 2015;3:141–7. https://doi.org/10.1016/s2213-8587(14)70007-5.Suche in Google Scholar

15. Liang, J, Chen, Y, Zhang, J, Ma, B, Hu, Y, Liu, Y, et al.. Associations of weight-adjusted body fat and fat distribution with bone mineral density in Chinese children aged 6–10 years. Int J Environ Res Publ Health 2020;17:1763. https://doi.org/10.3390/ijerph17051763.Suche in Google Scholar PubMed PubMed Central

16. Tian, L, Fat, YX. Sugar, and bone health: a complex relationship. Nutrients 2017;9:506.10.3390/nu9050506Suche in Google Scholar PubMed PubMed Central

17. Dong, X-L, Li, C-M, Cao, S-S, Zhou, L-P, Wong, M-S. A high-sucrose diet aggravates bone loss in ovariectomized female rats. J Nutr 2016;146:1172–9. https://doi.org/10.3945/jn.115.225474.Suche in Google Scholar PubMed

18. Maeda, M, Maeda, T, Ihara, K. Secular trends in obesity and serum lipid values among children in Oita City, Japan, during a 27-year period. J Atherosclerosis Thromb 2022;29:1709–26. https://doi.org/10.5551/jat.63056.Suche in Google Scholar PubMed PubMed Central

19. Stadler, JT, Marsche, G. Obesity-related changes in high-density lipoprotein metabolism and function. Int J Mol Sci 2020;21:8985. https://doi.org/10.3390/ijms21238985.Suche in Google Scholar PubMed PubMed Central

20. Azeez, TA. Osteoporosis and cardiovascular disease: a review. Mol Biol Rep 2023;50:1753–63. https://doi.org/10.1007/s11033-022-08088-4.Suche in Google Scholar PubMed

21. Li, S, Guo, H, Liu, Y, Wu, F, Zhang, H, Zhang, Z, et al.. Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women. Clin Endocrinol 2015;82:53–8. https://doi.org/10.1111/cen.12616.Suche in Google Scholar PubMed

22. Anagnostis, P, Florentin, M, Livadas, S, Lambrinoudaki, I, Goulis, DG. Bone health in patients with dyslipidemias: an underestimated aspect. Int J Mol Sci 2022;23:1639. https://doi.org/10.3390/ijms23031639.Suche in Google Scholar PubMed PubMed Central

23. Elefteriou, F, Ahn, JD, Takeda, S, Starbuck, M, Yang, X, Liu, X, et al.. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature 2005;434:514–20. https://doi.org/10.1038/nature03398.Suche in Google Scholar PubMed

24. Weitzmann, MN, Pacifici, R. Estrogen deficiency and bone loss: an inflammatory tale. J Clin Investig 2006;116:1186–94. https://doi.org/10.1172/JCI28550.Suche in Google Scholar PubMed PubMed Central

25. Almeida, M, Han, L, Martin-Millan, M, Plotkin, LI, Stewart, SA, Roberson, PK, et al.. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007;282:27285–97. https://doi.org/10.1074/jbc.m702810200.Suche in Google Scholar

26. Zhang, Q, Zhou, J, Wang, Q, Lu, C, Xu, Y, Cao, H, et al.. Association between bone mineral density and lipid profile in Chinese women. Clin Interv Aging 2020;15:1649–64. https://doi.org/10.2147/cia.s266722.Suche in Google Scholar PubMed PubMed Central

27. Liu, J, Wang, L, Sun, J, Liu, G, Yan, W, Xi, B, et al.. Bone mineral density reference standards for Chinese children aged 3–18: cross-sectional results of the 2013–2015 China Child and Adolescent Cardiovascular Health (CCACH) Study. BMJ open 2017;7:e014542. https://doi.org/10.1136/bmjopen-2016-014542.Suche in Google Scholar PubMed PubMed Central

28. Ersoy, GS, Simsek, EE, Vatansever, D, Kasikci, HO, Keser, B, Sakin, O. Lipid profile and plasma atherogenic index in postmenopausal osteoporosis. North Clin Istanb 2017;4:237–41. https://doi.org/10.14744/nci.2017.61587.Suche in Google Scholar PubMed PubMed Central

29. Li, GH-Y, Cheung, C-L, Au, PC-M, Tan, KC-B, Wong, IC-K, Sham, P-C. Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian randomization study. Int J Epidemiol 2020;49:1221–35. https://doi.org/10.1093/ije/dyz145.Suche in Google Scholar PubMed

30. Xie, R, Huang, X, Liu, Q, Liu, M. Positive association between high-density lipoprotein cholesterol and bone mineral density in U.S. adults: the NHANES 2011–2018. J Orthop Surg Res 2022;17:92. https://doi.org/10.1186/s13018-022-02986-w.Suche in Google Scholar PubMed PubMed Central

31. Cui, L-H, Shin, M-H, Chung, E-K, Lee, Y-H, Kweon, S-S, Park, K-S, et al.. Association between bone mineral densities and serum lipid profiles of pre- and post-menopausal rural women in South Korea. Osteoporos Int 2005;16:1975–81. https://doi.org/10.1007/s00198-005-1977-2.Suche in Google Scholar PubMed

32. Ghadiri-Anari, A, Mortezaii-Shoroki, Z, Modarresi, M, Dehghan, A. Association of lipid profile with bone mineral density in postmenopausal women in Yazd province. Int J Reprod Biomed 2016;14:597–602. https://doi.org/10.29252/ijrm.14.9.597.Suche in Google Scholar

33. Dimitri, P, Jacques, RM, Paggiosi, M, King, D, Walsh, J, Taylor, ZA, et al.. Leptin may play a role in bone microstructural alterations in obese children. J Clin Endocrinol Metab 2015;100:594–602. https://doi.org/10.1210/jc.2014-3199.Suche in Google Scholar PubMed PubMed Central

34. Dragojevič, J, Zupan, J, Haring, G, Herman, S, Komadina, R, Marc, J. Triglyceride metabolism in bone tissue is associated with osteoblast and osteoclast differentiation: a gene expression study. J Bone Miner Metabol 2013;31:512–19. https://doi.org/10.1007/s00774-013-0445-x.Suche in Google Scholar PubMed

35. Wei, J, Ferron, M, Clarke, CJ, Hannun, YA, Jiang, H, Blaner, WS, et al.. Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Investig 2014;124:1–13. https://doi.org/10.1172/jci72323.Suche in Google Scholar

36. Bredella, MA, Gill, CM, Gerweck, AV, Landa, MG, Kumar, V, Daley, SM, et al.. Ectopic and serum lipid levels are positively associated with bone marrow fat in obesity. Radiology 2013;269:534–41. https://doi.org/10.1148/radiol.13130375.Suche in Google Scholar PubMed PubMed Central

37. Schwartz, AV, Sigurdsson, S, Hue, TF, Lang, TF, Harris, TB, Rosen, CJ, et al.. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab 2013;98:2294–300. https://doi.org/10.1210/jc.2012-3949.Suche in Google Scholar PubMed PubMed Central

38. Nuttall, ME, Gimble, JM. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 2004;4:290–4. https://doi.org/10.1016/j.coph.2004.03.002.Suche in Google Scholar PubMed

39. Parhami, F, Jackson, SM, Tintut, Y, Le, V, Balucan, JP, Territo, M, et al.. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Min Res 1999;14:2067–78. https://doi.org/10.1359/jbmr.1999.14.12.2067.Suche in Google Scholar PubMed

40. Zhang, J, Hu, W, Zou, Z, Li, Y, Kang, F, Li, J, et al.. The role of lipid metabolism in osteoporosis: clinical implication and cellular mechanism. Genes Dis 2024;11:101122. https://doi.org/10.1016/j.gendis.2023.101122.Suche in Google Scholar PubMed PubMed Central

41. Urban, JB, Torres, W, Nunes, DS, Pelegrini, A, Kemper, HCG, Fernandes, RA. Sports participation plays a relevant role in the relationship between birth weight and bone mineral content in adolescents. Am J Hum Biol 2024;36:e24079. https://doi.org/10.1002/ajhb.24079.Suche in Google Scholar PubMed

42. Stojanović, E, Radovanović, D, Dalbo, VJ, Jakovljević, V, Ponorac, N, Agostinete, RR, et al.. Basketball players possess a higher bone mineral density than matched non-athletes, swimming, soccer, and volleyball athletes: a systematic review and meta-analysis. Arch Osteoporos 2020;15:123. https://doi.org/10.1007/s11657-020-00803-7.Suche in Google Scholar PubMed

43. Agostinete, RR, Werneck, AO, Narciso, PH, Ubago-Guisado, E, Coelho-e-Silva, MJ, Bielemann, RM, et al.. Resistance training presents beneficial effects on bone development of adolescents engaged in swimming but not in impact sports: ABCD growth study. BMC Pediatr 2024;24:247. https://doi.org/10.1186/s12887-024-04634-0.Suche in Google Scholar PubMed PubMed Central

44. Luiz-de-Marco, R, Gobbo, LA, Castoldi, RC, Maillane-Vanegas, S, Faustino-da-Silva, YdSV, Exupério, IN, et al.. Impact of changes in fat mass and lean soft tissue on bone mineral density accrual in adolescents engaged in different sports: ABCD growth study. Arch Osteoporos 2020;15:22. https://doi.org/10.1007/s11657-020-0707-x.Suche in Google Scholar PubMed

Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jpem-2024-0600).

Received: 2024-12-13
Accepted: 2025-04-17
Published Online: 2025-05-22
Published in Print: 2025-07-28

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Sunlight, supplements, and science: vitamin D as a tool for pediatric health care
  4. Mini Review
  5. Physical activity and vitamin D in children: a review of impacts on bone health and fitness
  6. Original Articles
  7. Association between overweight or obesity and vitamin D status in preschool children: an epidemiological survey in Beijing, China, 2021–2023
  8. Association between partial remission phase in type 1 diabetes and vitamin D receptor Fok1 rs2228570 polymorphism
  9. Optimal vitamin D status for Chinese infants in Hong Kong: insights from the relationship between serum 25-hydroxyvitamin D and parathyroid hormone levels
  10. Reviews
  11. The changing landscape in the evaluation of hypotonic polyuria in children and adolescents: the role of the new copeptin stimulation tests
  12. A systematic review and meta-analysis of the self-reported Pubertal Development Scale’s applicability to children
  13. Original Articles
  14. Assessing prediabetes and cardiometabolic risk in Danish youth with obesity
  15. Endocrinopathies in children with inborn errors of immunity: a single-center experience
  16. Relationship between blood lipids and bone mineral density in healthy preschoolers: a 12-month cohort study
  17. The causal role of endocrine disrupting chemicals in pubertal timing: a Mendelian randomization study
  18. Case Reports
  19. Vitamin D dependent rickets type 2A: a case series of two siblings with novel mutation in vitamin D receptor gene responded to high dose oral calcium and calcitriol
  20. Emergence of osteolysis as a new radiological feature in a case with a novel BMP2 gene variant
  21. Rare case of ACTH-independent Cushing syndrome: diagnostic challenges and management
https://doi.org/10.1515/jpem-2024-0600
Schlagwörter für diesen Artikel
bone mineral density; preschool children; blood lipid; cohort study

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Sunlight, supplements, and science: vitamin D as a tool for pediatric health care
  4. Mini Review
  5. Physical activity and vitamin D in children: a review of impacts on bone health and fitness
  6. Original Articles
  7. Association between overweight or obesity and vitamin D status in preschool children: an epidemiological survey in Beijing, China, 2021–2023
  8. Association between partial remission phase in type 1 diabetes and vitamin D receptor Fok1 rs2228570 polymorphism
  9. Optimal vitamin D status for Chinese infants in Hong Kong: insights from the relationship between serum 25-hydroxyvitamin D and parathyroid hormone levels
  10. Reviews
  11. The changing landscape in the evaluation of hypotonic polyuria in children and adolescents: the role of the new copeptin stimulation tests
  12. A systematic review and meta-analysis of the self-reported Pubertal Development Scale’s applicability to children
  13. Original Articles
  14. Assessing prediabetes and cardiometabolic risk in Danish youth with obesity
  15. Endocrinopathies in children with inborn errors of immunity: a single-center experience
  16. Relationship between blood lipids and bone mineral density in healthy preschoolers: a 12-month cohort study
  17. The causal role of endocrine disrupting chemicals in pubertal timing: a Mendelian randomization study
  18. Case Reports
  19. Vitamin D dependent rickets type 2A: a case series of two siblings with novel mutation in vitamin D receptor gene responded to high dose oral calcium and calcitriol
  20. Emergence of osteolysis as a new radiological feature in a case with a novel BMP2 gene variant
  21. Rare case of ACTH-independent Cushing syndrome: diagnostic challenges and management
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