Startseite Medizin Oral glucose tolerance test curve shape in Mexican children and adolescents with and without obesity
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Oral glucose tolerance test curve shape in Mexican children and adolescents with and without obesity

  • María Lola Evia-Viscarra ORCID logo , Emmanuel Jacobo-Tovar , Luis Fernando Meneses-Rojas und Rodolfo Guardado-Mendoza ORCID logo EMAIL logo
Veröffentlicht/Copyright: 11. September 2024
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 37 Heft 10

Abstract

Objectives

Mexican children with obesity are at a higher risk of developing type 2 diabetes mellitus (T2DM). The aim of the study was to compare oral glucose tolerance test (OGTT) characteristics: time of peak glucose, glucose level ≥155 mg/dL at 1 h, presence of metabolic syndrome (MetS), sensitivity, secretion, and oral disposition index (oDI) in children with and without obesity, according to oral glucose tolerance curve shape: monophasic or biphasic.

Methods

Cross-sectional study including 143 children. Groups were divided into (a) obese: biphasic (B-Ob) (n=55) and monophasic (M-Ob) (n=50), (b) without obesity: biphasic (B-NonOb) (n=20) and monophasic (M-NonOb) (n=18).

Results

Late glucose peak was more frequent in the M-Ob group (p<0.001). Glucose levels ≥155 mg/dL and MetS were more frequent in the M-Ob group but did not show significance. The groups with obesity (biphasic and monophasic) had higher indices of insulin resistance and insulin secretion compared to the nonobese groups (biphasic and monophasic) (p<0.001). AUC glucose was higher in the M-Ob group (p<0.05), and AUC insulin was higher in the M-NonOb group. oDI (Matsuda) was significantly lower in the M-Ob group compared to the other groups (p<0.001), and oDI-HOMA IR was higher in M-NonOb group (p=0.03).

Conclusions

All OGTT parameters could help to identify Mexican children at increased risk of developing T2DM, not only fasting plasma glucose and 2 h glucose. M-Ob in non-T2DM Mexican children reflects an early defect in glucose metabolism. Higher level of IR indexes in M-NonOb vs. B-NonOb could indicate an increased risk for T2DM of genetic origin.

Keywords: oral glucose tolerance test; curve shape; pediatric obesity; time glucose peak
Corresponding author: Rodolfo Guardado-Mendoza, Metabolic Research Laboratory, Department of Medicine and Nutrition, University of Guanajuato, León, México, E-mail:

  1. Research ethics: The study was approved by the HRAEB Research and Ethics in Research Committee (HRAEB-2013-013).

  2. Informed consent: Parental informed consent and children assent were obtained.

  3. Author contributions: MLEV and RGM conceptualization. MLEV, EJT, RGM evaluated the subjects included in the project and data curation. MLEV and RGM conducting the formal analysis, investigation, methodology, and project administration. MLEV, EJT, LFMR, RGM validation, visualization, writing draft, and writing review and editing. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: The raw data can be obtained upon request from the author when there is an acceptable justification.

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Received: 2024-05-22
Accepted: 2024-08-16
Published Online: 2024-09-11
Published in Print: 2024-10-28

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Refractory hypothyroidism in children: an overview
  4. Original Articles
  5. Oral glucose tolerance test curve shape in Mexican children and adolescents with and without obesity
  6. Reliability of self-reported pubertal development scale for girls in early adolescent: a school population-based study
  7. Allergic reactions to enzyme replacement therapy in children with lysosomal storage diseases and their management
  8. The role of Cardiotrophin-1 and echocardiography in early detection of subclinical diabetic cardiomyopathy in children and adolescents with type 1 diabetes mellitus
  9. Evaluation of the etiology of subclinical hypothyroidism in children
  10. Long-term efficacy and safety of PEGylated recombinant human growth hormone in treating Chinese children with growth hormone deficiency: a 5-year retrospective study
  11. Case Reports
  12. Effective and safe use of sirolimus in hyperinsulinemic hypoglycaemia refractory to medical and surgical therapy: a case series and review of literature
  13. Diabetes and CFAP126 gene mutation; are they really linked together?
  14. Pronounced neonatal breast enlargement beyond the first week of life and its regression correlates with serum prolactin levels – a case series
  15. A successful liver transplantation in a patient with neonatal-onset carbamoyl phosphate synthetase-1 deficiency
  16. Corrigendum
  17. New data supporting that early diagnosis and treatment are possible and necessary in intracellular cobalamin depletion: the case of transcobalamin II deficiency
https://doi.org/10.1515/jpem-2024-0250
Schlagwörter für diesen Artikel
oral glucose tolerance test; curve shape; pediatric obesity; time glucose peak

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Refractory hypothyroidism in children: an overview
  4. Original Articles
  5. Oral glucose tolerance test curve shape in Mexican children and adolescents with and without obesity
  6. Reliability of self-reported pubertal development scale for girls in early adolescent: a school population-based study
  7. Allergic reactions to enzyme replacement therapy in children with lysosomal storage diseases and their management
  8. The role of Cardiotrophin-1 and echocardiography in early detection of subclinical diabetic cardiomyopathy in children and adolescents with type 1 diabetes mellitus
  9. Evaluation of the etiology of subclinical hypothyroidism in children
  10. Long-term efficacy and safety of PEGylated recombinant human growth hormone in treating Chinese children with growth hormone deficiency: a 5-year retrospective study
  11. Case Reports
  12. Effective and safe use of sirolimus in hyperinsulinemic hypoglycaemia refractory to medical and surgical therapy: a case series and review of literature
  13. Diabetes and CFAP126 gene mutation; are they really linked together?
  14. Pronounced neonatal breast enlargement beyond the first week of life and its regression correlates with serum prolactin levels – a case series
  15. A successful liver transplantation in a patient with neonatal-onset carbamoyl phosphate synthetase-1 deficiency
  16. Corrigendum
  17. New data supporting that early diagnosis and treatment are possible and necessary in intracellular cobalamin depletion: the case of transcobalamin II deficiency
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